A5101623658- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Fatty Acid Research and Health
- Nitric Oxide and Endothelin Effects
- Adipokines, Inflammation, and Metabolic Diseases
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Paraoxonase enzyme and polymorphisms
- Glutathione Transferases and Polymorphisms
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Cardiac Imaging and Diagnostics
- Eicosanoids and Hypertension Pharmacology
- Diabetes and associated disorders
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Hormonal Regulation and Hypertension
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Antiplatelet Therapy and Cardiovascular Diseases
Kobe University
2016-2025
Hyogo University of Health Sciences
2013-2025
Nakamura Gakuen University
2019
NTT (Japan)
2019
National Institute for Physiological Sciences
2017
Genetic Resources Center
2017
Saitama Prefecture
2017
MedStar Washington Hospital Center
2016
Tomitahama Hospital
2015
Kobe Gakuin University
2013
A new member of the lipase gene family, initially termed endothelial (gene nomenclature, LIPG; protein, EL), is expressed in a variety different tissues, suggesting general role lipid metabolism. To assess hypothesis that EL plays physiological lipoprotein metabolism vivo, we have used targeting native murine locus and transgenic introduction human LIPG mice to modulate level expression. Evaluation these alleles C57Bl/6 background revealed an inverse relationship between HDL cholesterol...
Objective— To determine whether the administration of an active form vitamin D 3 (calcitriol) could prevent atherosclerosis through anti-inflammatory actions. Methods and Results— Recent clinical studies have shown that lack is a risk factor for cardiovascular events. Oral calcitriol decreased atherosclerotic lesions, macrophage accumulation, CD4 + T-cell infiltration at aortic sinus, when compared with corresponding observations in control mice. We observed significant increase Foxp3...
Abstract A previous report showed that the consumption of glutathione through oxidative stress activates synthetic pathway, which is accompanied by production ophthalmic acid from 2-aminobutyric (2-AB). We conducted a comprehensive quantification serum metabolites using gas chromatography-mass spectrometry in patients with atrial septal defect to find clues for understanding myocardial metabolic regulation, and demonstrated circulating 2-AB levels reflect hemodynamic changes. However,...
To gain fundamental information regarding the molecular basis of endothelial cell adhesive interactions during vascular formation, we have cloned and characterized a unique adhesion molecule. This molecule, named cell-selective molecule (ESAM), is new member immunoglobulin superfamily. The conceptual protein encoded by cDNA clones consists V-type C2-type domains as well hydrophobic signal sequence, single transmembrane region, cytoplasmic domain. Northern blot analysis showed ESAM to be...
Nitric oxide (NO) plays a central role in the pathogenesis of septic shock. However, NO produced by endothelial synthase (eNOS) shock is still unclear. We examined effect chronic eNOS overexpression and eNOS-derived lipopolysaccharide (LPS)-induced using transgenic (Tg) mice.LPS was intraperitoneally injected into Tg control mice. No differences existed peak plasma nitrate levels induced LPS between 2 genotypes. In LPS-treated mice, blood pressure progressively declined reached 60% basal...
Monocyte/macrophage infiltration to the arterial wall is an initial step in atherosclerosis, and monocyte chemoattractant protein-1 (MCP-1) thought play a central role recruitment of these cells. In present study, we examined local expression MCP-1 at vessel initiation development atherosclerosis. We transfected cDNA encoding rat into rabbit carotid artery with use hemagglutinating virus Japan (HVJ)-liposome method. The rabbits were divided following groups: (1) those fed normal chow...
Endothelial lipase (EL) expression correlates inversely with circulating high density lipoprotein (HDL) cholesterol levels in genetic mouse models, and human variation this locus has been linked to differences HDL levels. These data suggest a role for EL the development of atherosclerotic vascular disease. To investigate possibility, LIPG-null alleles were bred onto apoE knockout background, homozygous double animals characterized. Both mice had low when compared wild-type mice, but higher...
Objective— Eicosapentaenoic acid (EPA) has been shown to have beneficial effects on cardiovascular diseases, although the precise mechanism is unknown. We investigated effect of EPA regression atherosclerosis. Methods and Results— LDL-receptor–deficient mice were fed a high-cholesterol diet for 8 weeks build up aortic sinus atherosclerotic lesions then normal with or without 5% 4 weeks. Atherosclerotic histologically assessed, immunologic assays performed. treatment significantly regressed...
Background: The cytochrome P450 (CYP) 2C19*2 polymorphism is associated with reduced responsiveness to clopidogrel and poor clinical outcome after stent implantation. Despite the high frequency of this in Japanese patients, its contribution cardiac events thrombi drug-eluting (DES) implantation not clear population. Methods Results: One hundred patients received underwent follow-up optical coherence tomography (OCT) DES were divided into 2 groups: those at least one CYP2C19*2 allele (*2...
Objective— Vascular endothelial growth factor (VEGF) exerts proangiogenic action and induces activation of a variety signaling pathways, including the Rho family small G proteins. However, regulators proteins in vascular cells (ECs) are poorly understood. Here we attempted to clarify expression, subcellular localization, downstream effectors, role FGD5, member FGD guanine nucleotide exchange factors. Methods Results— FGD5 was shown be selectively expressed cultured human ECs....
Aim: Although statins increase the plasma concentration of high-density lipoprotein cholesterol (HDL-C), it has not been elucidated whether increased HDL particles possess normal antiatherosclerotic properties. Pitavastatin functions to HDL-C level and decrease lowdensity (LDL-C) level. In present study, we sought examine qualitative changes in during pitavastatin treatment. Methods: A total 30 patients with dyslipidemia were treated 2 mg for four weeks. The efflux capacity activities...
ATP citrate lyase (ACLY) is a key enzyme in de novo lipogenesis that generates acetyl-CoA from citrate. Although fatty acids are required for energy production and biomass synthesis the heart, regulatory mechanisms of ACLY-mediated pathological cardiac fibroblasts remain unknown. The aim this study was to investigate biological role ACLY remodeling. Adeno-associated virus serotype 9-mediated shRNA targeting Acly intravenously injected into C57BL/6J male mice. mice were subsequently...
Cholesterol uptake capacity (CUC) is a functional assessment of high-density lipoprotein (HDL) and has drawn attention for the risk stratification atherosclerotic cardiovascular disease (ASCVD). This study evaluated usefulness HDL-CUC as predictive marker long-term ASCVD events in patients with coronary artery (CAD). retrospective observational included 503 CAD who underwent revascularization. Blood was sampled from participants within three months before or after index The CUC assayed using...