A5048441665- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- Fatty Acid Research and Health
- Metabolomics and Mass Spectrometry Studies
- RNA Research and Splicing
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Eicosanoids and Hypertension Pharmacology
- Cancer, Hypoxia, and Metabolism
- Lipoproteins and Cardiovascular Health
- Heart Failure Treatment and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Mitochondrial Function and Pathology
- Nitric Oxide and Endothelin Effects
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Gut microbiota and health
- Congenital Anomalies and Fetal Surgery
- Coronary Interventions and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Biochemical effects in animals
- Cholesterol and Lipid Metabolism
- Paraoxonase enzyme and polymorphisms
Kobe University
2016-2025
Japan Agency for Medical Research and Development
2019-2024
Brigham and Women's Hospital
2012-2023
National Institute of Biomedical Innovation, Health and Nutrition
2023
Shizuoka University
2023
University of Shizuoka
2023
Kyoto University
2009-2023
Kinki Central Hospital
2023
GC Corporation (Japan)
2023
Horizon Therapeutics (United Kingdom)
2023
Resolution of acute inflammation is an active process locally controlled by a novel genus specialized pro-resolving mediators (SPM) that orchestrate key resolution responses. Hence, it general interest to identify individual bioactive and profile their biosynthetic pathways with related isomers as well relation(s) classic eicosanoids in mammalian tissues. Lipid mediator (LM)-SPM levels signature profiles were investigated using liquid chromatography-tandem mass spectrometry (LC-MS-MS)-based...
Mouse mothers transfer metabolic mode Obesity and diseases tend to go together, humans who become obese are also prone type 2 diabetes cardiovascular problems. Starting with the observation that offspring of germ-free mice tended on high-fat diets, Kimura et al. investigated how presence microbiota might be protective in (see Perspective by Ferguson). Short-chain fatty acids (SCFAs) from known suppress insulin signaling reduce fat deposition adipocytes. Further experiments showed SCFAs...
The life span of intestinal epithelial cells (IECs) is short (3-5 days), and its regulation thought to be important for homeostasis the epithelium. We have now investigated role commensal bacteria in IEC turnover small intestine. proliferative activity IECs crypts as well migration these along crypt-villus axis were markedly attenuated both germ-free mice specific pathogen-free (SPF) treated with a mixture antibiotics, antibiotics selective Gram-positive being most effective this regard....
Objective— To determine whether the administration of an active form vitamin D 3 (calcitriol) could prevent atherosclerosis through anti-inflammatory actions. Methods and Results— Recent clinical studies have shown that lack is a risk factor for cardiovascular events. Oral calcitriol decreased atherosclerotic lesions, macrophage accumulation, CD4 + T-cell infiltration at aortic sinus, when compared with corresponding observations in control mice. We observed significant increase Foxp3...
Accumulating evidence suggests that several subsets of regulatory T cells actively mediate immunologic tolerance play crucial roles in atherogenesis. Recently, orally administered anti-CD3 monoclonal antibody has been shown as an inducer novel expressing latency-associated peptide (LAP) on their surface, which potently prevents systemic autoimmunity. In the present study, we hypothesized oral treatment may inhibit atherosclerosis mice.Six-week-old apolipoprotein E-deficient mice a standard...
ABSTRACT Conventional tumor markers are unsuitable for detecting carcinoma at an early stage and lack clinical efficacy utility. In this study, we attempted to investigate the differences in serum metabolite profiles of gastrointestinal cancers healthy volunteers using a metabolomic approach searched sensitive specific biomarker candidates. Human samples were obtained esophageal ( n = 15), gastric 11), colorectal 12) cancer patients 12). A model evaluating candidates was constructed multiple...
Abstract Aging is associated with an overt inflammatory phenotype and physiological decline. Specialized proresolving lipid mediators (SPMs) are endogenous autacoids that actively promote resolution of inflammation. In this study, we investigated acute inflammation in aging the roles SPMs. Using a self-resolving peritonitis indices coupled mediator metabololipidomics, found aged mice had both delayed reduced The SPM precursor docosahexaenoic acid accelerated via increased SPMs promoted human...
Sepsis, a life-threatening organ dysfunction caused by dysregulated host response to infection, is major public health concern with high mortality and morbidity. Although inflammatory responses triggered infection are crucial for defense against invading microbes, the excessive inflammation often causes tissue damage leading dysfunction. Resolution of inflammation, an active immune process mediated endogenous lipid mediators (LMs), important maintain homeostasis.We sought determine role...
Abstract Resolution of acute inflammation is an active event accompanied by biosynthesis specialized proresolving mediators (SPM). We employed a systems approach to determine the impact CO in resolution programs during self-limited mice. Compared with ambient air, inhaled gas (250 ppm) significantly limited PMN infiltration (∼44%, 6 h) into peritoneum and shortened interval from 4 2 h. profiled exudate lipid (LM) via metabololipidomics, reduced leukotriene B4 (21 ± 11 versus 59 24 pg/mouse,...
Gut microbiome composition or circulating microbiome-related metabolites in patients with heart failure (HF) have not been investigated at different time points (i.e., the decompensated (Decomp) and compensated (Comp) phases).
Abstract A previous report showed that the consumption of glutathione through oxidative stress activates synthetic pathway, which is accompanied by production ophthalmic acid from 2-aminobutyric (2-AB). We conducted a comprehensive quantification serum metabolites using gas chromatography-mass spectrometry in patients with atrial septal defect to find clues for understanding myocardial metabolic regulation, and demonstrated circulating 2-AB levels reflect hemodynamic changes. However,...
The gut microbiome has emerged as a key regulator of obesity; however, its role in brown adipose tissue (BAT) metabolism and association with obesity remain to be elucidated. We found that the levels circulating branched-chain amino acids (BCAA) their cognate α-ketoacids (BCKA) were significantly correlated body weight humans mice BCAA catabolic defects BAT associated diet-induced (DIO) mice. Pharmacological systemic enhancement activity reduced plasma BCKA protected against these effects...
Metabolomics provides data about all the metabolic processes of a cell or organism. So far, changes that occur in levels metabolites during development colitis have not been fully elucidated. Here we examined metabolite serum and colon tissue mice using gas chromatography mass spectrometry (GC/MS) with aim achieving detailed understanding pathogenesis inflammatory bowel disease (IBD). To induce colitis, C57BL/6J were administered 3.0% dextran sulfate sodium (DSS) their drinking water for 5...
Metabolomics has recently undergone rapid development; however, metabolomic analysis in cerebrospinal fluid (CSF) is not a common practice. We analyzed the metabolite profiles of preoperative CSF samples from 32 patients with histologically confirmed glioma using gas chromatography/mass spectrometry (GC/MS). assessed how alterations levels were related to World Health Organization (WHO) tumor grades, location, gadolinium enhancement on magnetic resonance imaging (MRI), and isocitrate...
Objective— Eicosapentaenoic acid (EPA) has been shown to have beneficial effects on cardiovascular diseases, although the precise mechanism is unknown. We investigated effect of EPA regression atherosclerosis. Methods and Results— LDL-receptor–deficient mice were fed a high-cholesterol diet for 8 weeks build up aortic sinus atherosclerotic lesions then normal with or without 5% 4 weeks. Atherosclerotic histologically assessed, immunologic assays performed. treatment significantly regressed...
Abstract Faecal lipopolysaccharides (LPS) have attracted attention as potent elements to explain a correlation between the gut microbiota and cardiovascular disease (CVD) progression. However, underlying mechanism of how specific bacteria contribute faecal LPS levels remains unclear. We retrospectively analysed data 92 patients found that abundance genus Bacteroides was significantly negatively correlated with levels. The controls showed higher than in CVD. endotoxin units LPS, determined by...
Abstract Cancer cells optimize nutrient utilization to supply energetic and biosynthetic pathways. This metabolic process also includes redox maintenance epigenetic regulation through nucleic acid protein methylation, which enhance tumorigenicity clinical resistance. However, less is known about how cancer exhibit flexibility sustain cell growth survival from starvation. Here, we find that serine glycine levels were higher in low-nutrient regions of tumors glioblastoma multiforme (GBM)...