A5061305359- Asymmetric Hydrogenation and Catalysis
- Organoboron and organosilicon chemistry
- Chemical Synthesis and Analysis
- Cosmology and Gravitation Theories
- Black Holes and Theoretical Physics
- Carbon dioxide utilization in catalysis
- Luminescence and Fluorescent Materials
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Robot Manipulation and Learning
- Advancements in Battery Materials
- Analytical Chemistry and Chromatography
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Ergonomics and Musculoskeletal Disorders
- Organometallic Complex Synthesis and Catalysis
- Synthesis and Properties of Aromatic Compounds
- Catalysis for Biomass Conversion
- Neural Networks and Applications
- Quantum and electron transport phenomena
- Physics of Superconductivity and Magnetism
- Click Chemistry and Applications
- Insect-Plant Interactions and Control
- Molecular spectroscopy and chirality
- Noncommutative and Quantum Gravity Theories
- Liver Disease Diagnosis and Treatment
Panasonic (Japan)
2016-2025
Pan American Health Organization (Cuba)
2016-2024
Nagoya University
2012-2024
Matsushita Memorial Hospital
2024
Panasonic (Poland)
2016-2024
Takeda (Japan)
2024
Novo Nordisk (Italy)
2024
Kyowa Kirin (Japan)
2024
Astellas Pharma (Japan)
2024
Eli Lilly (Japan)
2024
Mouse mothers transfer metabolic mode Obesity and diseases tend to go together, humans who become obese are also prone type 2 diabetes cardiovascular problems. Starting with the observation that offspring of germ-free mice tended on high-fat diets, Kimura et al. investigated how presence microbiota might be protective in (see Perspective by Ferguson). Short-chain fatty acids (SCFAs) from known suppress insulin signaling reduce fat deposition adipocytes. Further experiments showed SCFAs...
Abstract Background Non-alcoholic liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome, and it can progress to non-alcoholic steatohepatitis (NASH). Alterations in gut microbiome have been implicated development NAFLD/NASH, although underlying mechanisms remain unclear. Results We found that consumption prebiotic inulin markedly ameliorated phenotype including steatosis fibrosis, mice. Inulin resulted global changes microbiome, concomitant enrichment genera Bacteroides...
In this paper, we propose a new method for decomposing pattern classification problems based on the class relations among training data. By using method, can divide K-class problem into series of ((2)(K)) two-class problems. These are to discriminate Ci from Cj i=1, ..., K and j = i+1, while existence data belonging other K-2 classes is ignored. If discriminating still hard be learned, further break down it set subproblems as small expect. Since each treated completely separate with proposed...
A novel catalytic method for the straightforward hydrogenation of carboxamides and esters to primary alcohols has been developed. Chiral modification in ligand sphere well-defined Cp*Ru catalyst molecule opens up a new possibility development an enantioselective racemic substrates via dynamic kinetic resolution.
Highly efficient isomerization of allylic alcohols into saturated carbonyls is accomplished using the catalyst system Cp*RuCl[Ph2P(CH2)2NH2-κ2-P,N]-KOt-Bu (Cp* = η5-C5(CH3)5) under mild conditions. Mechanistic consideration based on isotope-labeling experiments indicated present reaction applicable to asymmetric racemic sec-allylic with a prochiral olefin via dynamic kinetic resolution. A concise synthesis muscone has been achieved, where an optically active ligand key reaction.
This work represents the first catalytic hydrogenation of imides into amides and primary alcohols, in which unique chemoselectivity is originated from bifunctional nature ruthenium-NH moiety catalyst.
From the viewpoint of cost and safety, aqueous sodium-ion batteries are attractive candidate for large-scale energy storage. Although operating voltage range battery is theoretically limited to 1.23 V by electrochemical decomposition water, restriction a little bit eased in real system charge/discharge overvoltage. Effect concentrated electrolyte on operation was studied Na-ion with Na2MnFe(CN)6 hexacyanoferrates cathode NaTi2(PO4)3 NASICON-type anode, order increase discharge voltage....
Abstract High discharge voltage of more than 2 V is achieved in a novel aqueous sodium‐ion battery with the combination Prussian blue‐type sodium manganese hexacyanoferrate cathode, and similar potassium hexacyanochromate anode. Here, highly concentrated perchlorate electrolyte 2.8 electrochemical window used. By element analysis, anode containing little possibly serves as suitable host–guest anode, similarly cathode extracting/inserting ion electrolyte. Open‐framework electrodes but mobile...
We demonstrate rapid single-flux-quantum (RSFQ) circuits with reduced energy consumption by lowering the driving voltages and critical currents of Josephson junctions (JJs). At lowered voltages, statically consumed bias resistors (which is dominant in RSFQ circuits) reduced. In addition, we show that when are driven constant dynamic resulting from switching JJs because suppression amplitudes signal voltage pulses, even though speed becomes slower. Utilization miniaturized smaller also leads...
Abstract Background Previous studies have investigated the association between ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) and incidence diabetes in adults discovered that a high TG/HDL-C was linked an elevated risk new-onset diabetes. However, comparison predicting development among lipid profiles including ratio, cut-off value has received limited attention. We examined relationship onset addition applicable for onset. Methods This study included 120,613...
The rapid hydrogenation of simple aromatic ketones is accomplished by using a combination (η5-C5(CH3)5)Ru complexes and primary amines as catalyst in 2-propanol. In particular, 1,2-diamines with tertiary amino groups at both ends exhibit significant ligand acceleration effect. Isotope-labeling experiments D2 2-propanol-dn reveal that 2-propanol participates the activation H2 based on metal/NH bifunctional effect to facilitate hydrogenation. Asymmetric prochiral chiral version catalysts...
We demonstrate rapid single-flux-quantum (RSFQ) circuits with reduced energy consumption by lowering the driving voltages and critical currents of Josephson junctions (JJs). At lowered voltages, statically consumed bias resistors (which is dominant in RSFQ circuits) reduced. In addition, we show that when are driven constant dynamic resulting from switching JJs because suppression amplitudes signal voltage pulses, even though speed becomes slower. Utilization miniaturized smaller also leads...
Abstract Electron‐deficient heteroacenes that contain two tricoordinate boron atoms in their acene skeletons and planarized phenyl ether moieties at periphery were synthesized via the borylation of silicon‐bridged precursors. X‐ray crystallographic analysis revealed quinoidal structures, which give rise to two‐step reversible redox processes for both reduction oxidation. These compounds exhibit intense absorption sharp fluorescence bands with vibronic structures near‐infrared (NIR) region....
This study presents experiments on the imitative interactions between a small humanoid robot and user. A dynamic neural network model of mirror system was implemented in robot, based recurrent with parametric bias (RNNPB). The showed that after learns multiple cyclic movement patterns as embedded RNNPB, it can regenerate each pattern synchronously movements human who is demonstrating corresponding front robot. Further, exhibits diverse interactive responses when user demonstrates novel...
T. Ohta, M. Ito, A. Tsuneto and H. Takaya, J. Chem. Soc., Commun., 1994, 2525 DOI: 10.1039/C39940002525
An efficient oxidative lactonization of 1,4-diols in acetone is accomplished by the well-defined ruthenium catalyst, whose bifunctional nature underlies high efficiency as well unique chemo- and regioselectivity reaction which provides a rapid access to γ-butyrolactones including flavor lactones hinokinin, muricatacin.
Highly enantioselective hydrogenative desymmetrization of bicyclic imides has been developed with chiral Cp*Ru(PN) catalysts. The present hydrogenation directly provides stereochemically well-defined cyclic compounds excellent enantiomeric exessses, which might otherwise require a detour to reach.
Awakening of the Cp one: The bifunctional complex 1 facilitates interaction with substrates bearing less electrophilic carbon atoms than ketones, epoxides, and imides. title reaction was applicable to reduction Evans' asymmetric alkylation products chiral alcohols along good recovery oxazolidinone auxiliary. EWG = electron-withdrawing group.
Abstract Embedding two boron atoms into a polycyclic aromatic hydrocarbon (PAH) leads to the formation of neutral analogue that is isoelectronic corresponding dicationic PAH skeleton, which can significantly alter its electronic structure. Based on this concept, we explore herein identification near‐infrared (NIR)‐emissive PAHs with aid an in silico screening method. Using perylene as scaffold, embedded and fused thiophene rings it. design all possible structures (ca. 2500 entities) were...
ABSTRACT Aims In Japan, several prediction models and scoring systems for type 2 diabetes have been reported; however, none high utility. We developed a new clinical model the onset of diabetes. Materials Methods The development dataset was obtained from 72,124 Japanese employees who participated in health check‐up programme conducted by Panasonic Corporation (Osaka, Japan), were aged 40 years or older, diabetes‐free at baseline, followed‐up up to 10 years. external validation 12,885...
We analyzed the substrate specificity of six human α1,3‐fucosyltransferases (α1,3FUTs) for 2‐aminobenzamide (2AB)‐labelled polylactosamine acceptor, Galβ1‐4GlcNAcβ1‐3Galβ1‐4GlcNAcβ1‐3Galβ1‐4GlcNAc‐2AB (3LN‐2AB). FUT9 preferentially fucosylated distal GlcNAc residue chain while other four α1,3FUT members, FUT3, FUT4, FUT5 and FUT6, inner residue. This indicated that exhibits more efficient activity synthesis Lewis x carbohydrate epitope (Le ; CD15; stage‐specific embryonal antigen‐1...