A5090866721- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Nutrition and Health in Aging
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Alcohol Consumption and Health Effects
- Pharmacology and Obesity Treatment
- Heart Rate Variability and Autonomic Control
- Hormonal and reproductive studies
- Chronic Kidney Disease and Diabetes
- Gut microbiota and health
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Body Composition Measurement Techniques
- Sodium Intake and Health
- Obesity, Physical Activity, Diet
Kyoto Prefectural University of Medicine
2016-2025
DMG Mori (Japan)
2024
New York University Press
2016
Cambridge University Press
2016
Osaka Prefecture University
2008
Kyoto Prefectural University
2005
Osaka Hospital
2001-2005
Kobe Pharmaceutical University
2003
Koshigaya Municipal Hospital
2000
Meiji University of Integrative Medicine
1997
Microplastics (MPs) are small particles of plastic (≤5mm in diameter). In recent years, oral exposure to MPs living organisms has been a cause concern. Leaky gut syndrome (LGS), associated with high-fat diet (HFD) mice, can increase the entry foreign substances into body through intestinal mucosa.We aimed evaluate pathophysiology outcomes consuming and simultaneous intake MPs, focusing on endocrine metabolic systems.C57BL6/J mice were fed normal (ND) or HFD without polystyrene MP for 4 wk...
Metabolically healthy obesity (MHO) is a unique phenotype that apparently protects people from the metabolic complications of obesity. The association between MHO and incident CKD unclear. Thus, this study investigated CKD.A total 3136 Japanese participants were enrolled in an 8-year follow-up cohort 2001. status was assessed by common clinical markers: BP, triglycerides, HDL cholesterol, fasting plasma glucose concentrations. Body mass index ≥25.0 kg/m(2) defined as proteinuria or eGFR <60...
The aim of this study was to evaluate the impact non-alcoholic fatty liver disease (NAFLD) on incident type 2 diabetes mellitus (T2DM) in non-overweight individuals with NAFLD. A population-based retrospective cohort 4629 participants who were enrolled a health check-up programme for more than 10 years. standardized questionnaire and abdominal ultrasonography used diagnose cut-off point BMI 23 kg/m(2) define overweight (≥23.0 kg/m(2)) or (<23.0 kg/m(2)). primary outcome T2DM. Over mean...
Recent cross-sectional studies have been reported the possibility that light to moderate alcohol consumption might be negatively associated with fatty liver. However, there has no large-scale longitudinal study addressing an impact of on a development liver diagnosed by ultrasonography. Thus, we investigated natural history liver.We analyzed 5437 apparently healthy Japanese who received health checkup programs repeatedly over 10 years. In this study, used standardized questionnaire for...
Skipping breakfast or irregular is associated with poor glycemic control. However, a relationship between the timing of dinner and control in people type 2 diabetes remains indefinite. Therefore, we investigated late-night-dinner diabetes. We performed questionnaire survey for lifestyle factors this cross-sectional study. defined having later than eight pm as late-night-dinner. examined differences clinical metabolic parameters those who have do not have. also HbA1c, using multiple...
Triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) has been recommended for surrogates of insulin resistance. However, it remains be elucidated the association between TG/HDL-C and incident fatty liver.To investigate liver.We performed population-based historical cohort study consisted with 4518 healthy Japanese who received yearly health-checkup programmes over decade. Fatty liver was diagnosed using ultrasonography.During observation periods, 38.8% (case/N...
Nonalcoholic fatty liver disease (NAFLD) is known as a risk of incident cardiovascular (CVD). About 20% NAFLD occurs in nonobese individuals. However, it remains to be elucidated the association between nonoverweight with and CVD. Therefore, we investigated for We performed post-hoc analysis previous prospective cohort study, which 1647 Japanese were enrolled. Abdominal ultrasonography was used diagnose NAFLD. Overweight defined body mass index ≥23 kg/m2, recommended by World Health...
To investigate the acute effects of coronavirus disease 2019 (COVID-19) on lifestyle and metabolic parameters in patients with type 2 diabetes mellites. This cross-sectional retrospective cohort study induced 203 who completed a questionnaire regarding stress levels lifestyles. Data levels, sleep time, exercise, total diet, snack, prepared food intake were obtained from questionnaires. The changes body weight or HbA1c determined by comparing values at time was administered to those noted 3...
Propolis contains a variety of chemical compounds, including polyphenols, flavonoids, phenolic aldehydes, amino acids and vitamins, presents numerous biological pharmacological properties. The aim the present study was to evaluate effect propolis on blood examination data in patients with type 2 diabetes. In double-blind, 8-week randomized controlled study, 80 diabetes were enrolled. Patients randomly assigned receive Brazilian green (226.8 mg/day for 8 weeks) (n=41) or placebo (n=39)....
Background . The triglyceride and glucose index (TyG), defined as the product of triglycerides (TG) fasting plasma (FPG), is reported a surrogate for insulin resistance. Although cross-sectional study revealed association between TyG-index prevalence nonalcoholic fatty liver disease (NAFLD), few studies have investigated incident NAFLD. Here we whether can be used to predict Methods This historical cohort included 16,093 apparently healthy Japanese individuals. was calculated by established...
Abstract Background Previous studies have investigated the association between ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) and incidence diabetes in adults discovered that a high TG/HDL-C was linked an elevated risk new-onset diabetes. However, comparison predicting development among lipid profiles including ratio, cut-off value has received limited attention. We examined relationship onset addition applicable for onset. Methods This study included 120,613...
Abstract Nonalcoholic steatohepatitis (NASH) is a progressive disorder with aberrant lipid accumulation and subsequent inflammatory profibrotic response. Therapeutic efforts at reduction via increasing cytoplasmic lipolysis unfortunately worsens hepatitis due to toxicity of liberated fatty acid. An alternative approach could be through autophagic disposal, i.e., lipophagy. We engineered synthetic adaptor protein induce lipophagy, combining droplet-targeting signal optimized LC3-interacting...
Obesity is a global health concern that promotes chronic low-grade inflammation, leading to insulin resistance, key factor in many metabolic diseases. Angiotensin 1–7 (Ang 1–7), component of the renin-angiotensin system (RAS), exhibits anti-inflammatory effects obesity and related disorders, though its mechanisms remain unclear. In this study, we examined effect Ang on inflammation white adipose tissue (WAT) dietary-induced obese mice. Monocyte chemoattractant protein-1 (MCP-1) produced by...