A5020255729- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Estrogen and related hormone effects
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Gynecological conditions and treatments
- Ovarian cancer diagnosis and treatment
- Menopause: Health Impacts and Treatments
- Reproductive Biology and Fertility
- Effects and risks of endocrine disrupting chemicals
- Reproductive tract infections research
- Birth, Development, and Health
- Menstrual Health and Disorders
- Connective tissue disorders research
- Cancer Risks and Factors
- Hormonal and reproductive studies
- Ovarian function and disorders
- Adipose Tissue and Metabolism
- Pregnancy and preeclampsia studies
- Cervical Cancer and HPV Research
- Pelvic and Acetabular Injuries
- Minimally Invasive Surgical Techniques
- Syphilis Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
Kyoto Prefectural University of Medicine
2016-2025
City Hospital
2022
Otsu Municipal Hospital
2022
Fudan University
2022
Kyoto Prefectural University
2019-2021
Kyoto College of Medical Science
2021
Graduate School USA
2020
World Health Organization Regional Office for the Western Pacific
2020
National Center for Global Health and Medicine
2020
Nihon University
2020
ABSTRACT Recently, the first Neisseria gonorrhoeae strain (H041) that is highly resistant to extended-spectrum cephalosporin (ESC) ceftriaxone, last remaining option for empirical first-line treatment, was isolated. We performed a detailed characterization of H041, phenotypically and genetically, confirm finding, examine its antimicrobial resistance (AMR), elucidate mechanisms. H041 examined using seven species-confirmatory tests, antibiograms (30 antimicrobials), porB sequencing, N....
To determine whether local estrogen production takes place in endometriotic or adenomyotic tissues, eutopic endometrium from patients with endometriosis adenomyosis, and normal endometrium, tissue specimens were examined by immunohistochemistry, catalytic activity, mRNA expression for aromatase cytochrome P450 (P450arom). P4500arom was immunohistochemically localized the cytoplasm of glandular cells respective diseases, whereas receptors progesterone nuclei stroma. Aromatase activity...
Our aim was to study ways improve IVF success rates in women with suspected endometrial receptivity defects. We conducted a retrospective cohort examining the effect of letrozole (aromatase inhibitor) on integrin expression as marker receptivity. compared outcomes 97 infertile who had undergone ανβ3 assessment by immunohistochemistry mid-luteal biopsies. Of 79 undergoing standard IVF, 29 (36.7%) lacked normal expression. Eighteen other low were studied after receiving during early...
Leptin, the obese (ob) gene product, is secreted by adipocytes and regulates appetite through interaction with hypothalamic leptin receptors. Leptin may also have a stimulatory effect on reproductive function. Furthermore, receptor mRNA expressed in ovary, suggesting direct its The present study examines role of oestrogen-producing activity human luteinized granulosa cells. cells were obtained from in-vitro fertilization pre-ovulatory follicles, precultured for 24 h presence 5%...
Abstract Leptin is secreted by adipocytes and regulates appetite through interaction with hypothalamic leptin receptors (OB-R). Accumulated evidence shows that involved in the stimulation of reproductive functions local expression OB-R ovary, oocyte, embryo, placenta plays a role early development. To investigate implantation, we examined human endometrium. Northern Western blot analyses RT-PCR showed long form (OB-RL) messenger ribonucleic acid (mRNA) protein were expressed. In contrast,...
Endometriosis is a chronic inflammatory disease associated with altered immune response to endometrial cells facilitating the implantation and proliferation of ectopic tissues. Although regulatory T (Treg) play key role in cell–mediated development disorders, their significance endometriosis remains be elucidated. Recently, CD4+CD45RA− forkhead box protein 3 (Foxp3)hi cells, activated Treg have been identified as functionally true suppressive population cells. To investigate endometriosis....
Abstract Context Regulatory T (Treg) cells and T-helper-17 (Th17) may be involved in endometriosis. Information on the pattern of change percentages Treg Th17 peripheral blood (PB) peritoneal fluid (PF) women with early advanced endometriosis is unclear. Objective To investigate PB PF Methods We recruited 31 laparoscopically histologically confirmed, revised American Society Reproductive Medicine stage I-II endometriosis, 39 III-IV 36 control subjects without visible samples were collected...
Abstract Problem Intrauterine microbial colonization and its association with the pathogenesis of endometriosis via an innate immune cascade have been reported. As a potential source transmission, information on in cervical mucus is unknown. We investigated pattern microbiota collected from women without using next‐generation sequencing (NGS) technology. Method study Cervical samples were (n = 30) 39) endometriosis. The communities group control examined by Gram staining NGS targeting V5‐V6...
BACKGROUND: The aim of this study was to evaluate the diagnostic significance CA-125 for endometriosis without ovarian endometriomas. METHODS: Preoperative serum levels were measured in 775 consecutive women diagnosed by laparoscopy or laparotomy with endometriosis, adenomyosis, leiomyomas, normal pelvis. RESULTS: Receiver operating characteristic curve analysis revealed that area under endometriomas 0.788, significantly smaller than (0.935, P<0.05). In diagnosis endometriomas, both maximal...
Abstract Estrogen-related receptor alpha (ERRα), which shares structural similarities with estrogen receptors, is associated tumor progression in endometrial cancer, but little known about the detailed underlying mechanism. We investigated whether ERRα, cooperation peroxisome proliferator-activated gamma coactivator 1-alpha (PGC-1α), could participate epithelial-mesenchymal transition (EMT) cancer through cancer-stromal interactions. Two cell lines, Ishikawa and HEC-1A, transfected...