A5086107574- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Estrogen and related hormone effects
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Gynecological conditions and treatments
- Ovarian cancer diagnosis and treatment
- Birth, Development, and Health
- Menopause: Health Impacts and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Intestinal and Peritoneal Adhesions
- Connective tissue disorders research
- Kruppel-like factors research
- Advanced Memory and Neural Computing
- Antifungal resistance and susceptibility
- Minimally Invasive Surgical Techniques
- Pelvic floor disorders treatments
- Fungal Infections and Studies
- Neural Networks and Reservoir Computing
- Menstrual Health and Disorders
- Service-Oriented Architecture and Web Services
- COVID-19 Impact on Reproduction
- Histone Deacetylase Inhibitors Research
- Case Reports on Hematomas
- Berry genetics and cultivation research
Kyoto Prefectural University of Medicine
2016-2025
Meijo University
2025
Kyoto College of Medical Science
2021
Graduate School USA
2020
Kyoto Prefectural University
2019
Nantan General Hospital
2015
NTT (Japan)
1996-2006
Tokyo Institute of Technology
1991
Endometriosis is a chronic inflammatory disease associated with altered immune response to endometrial cells facilitating the implantation and proliferation of ectopic tissues. Although regulatory T (Treg) play key role in cell–mediated development disorders, their significance endometriosis remains be elucidated. Recently, CD4+CD45RA− forkhead box protein 3 (Foxp3)hi cells, activated Treg have been identified as functionally true suppressive population cells. To investigate endometriosis....
Abstract Background Autism spectrum disorders (ASD) are pervasive developmental characterized by social deficits and restrictive patterns of behavior interests. Epilepsy is comorbidity in ASD patients. The imbalance excitation inhibition neural circuitry hypothesized for the pathophysiology as well epilepsy. It epidemiologically reported that administration valproic acid (VPA) during pregnancy increases risk offspring. In this study, we investigated therapeutic potential anti-epileptic drugs...
Abstract Aim We aimed to evaluate whether hormonal therapy immediately after postsurgical recurrence of ovarian endometrioma controls disease progression and can be an alternative therapeutic option avoid multiple repeat surgeries. Methods enrolled 146 patients treated for at the University Hospital Kyoto Prefectural Medicine between 2009 2015. After laparoscopic cystectomy using stripping technique, opening cul‐de‐sac obliterations complete resection deep infiltrating endometriosis lesions,...
Endometriosis is an estrogen-dependent disease. Abnormally biosynthesized estrogens in endometriotic tissues induce the growth of lesion and worsen endometriosis-associated pelvic pain. Dienogest (DNG), a selective progesterone receptor agonist, widely used to treat endometriosis efficiently relieves symptoms. However, its pharmacological action remains unknown. In this study, we elucidated effect DNG on enzymes involved local estrogen metabolism endometriosis. Surgically obtained specimens...
Estrogen-related receptor (ERR)α presents structural similarities with estrogen (ER)α. However, it is an orphan not binding to naturally occurring estrogens. This study was designed investigate the role of ERRα in endometrial cancer progression. Immunohistochemistry analysis on 50 specimens from patients showed that expressed all examined tissues and elevated expression levels were associated advanced clinical stages serous histological type (p < 0.01 for each). knockdown siRNA suppressed...
AF-6/afadin plays an important role in the formation of adherence junctions. In breast and colon cancer, loss induces cell migration invasion. We aimed to elucidate human endometrial cancer. Morphology expression cancer lines was investigated by 3-dimensional culture. used Matrigel invasion assay demonstrate knockdown induced invasive capability. Cell proliferation performed estimate chemoresistance doxorubicin, paclitaxel cisplatin knockdown. The associations between clinicopathological...
•Malignant transformation of deep infiltrating endometriosis involving the bladder is quite rare.•We review eight relevant cases which have been reported.•This second case fulfilling Sampson and Scott criteria.
Diagnostic laparoscopy is useful in the management of gynecological cancers; however, it can occasionally result detection other malignancies. Occult breast cancer (OBC) metastatic without a recognized primary lesion. We report rare case OBC that was detected laparoscopically. A 64-year-old female presented to our hospital with back pain. Magnetic resonance imaging (MRI) revealed 50 mm multicystic tumor an internal nodule right ovary. Positron emission tomography/computed tomography showed...
Abstract Congenital cutaneous candidiasis is a very rare disease with less than 100 cases published in the medical literature. Neonates having this present systemic skin lesions caused by intrauterine Candida infections. We case of threatened premature delivery due to chorioamnionitis, which both maternal postpartum endometritis and neonatal congenital candidiasis. A 34‐year‐old woman who was admitted for fetal membrane bulging at 20 weeks gestation underwent McDonald cervical cerclage....
Introduction. The incidence of endometriosis affecting skin tissue represents only 0.5-1.0% all cases. A malignancy in the abdominal wall arising from following cesarean section is even rarer; 21 cases have previously been reported. therapeutic strategy has not determined because limited We report a case clear cell adenocarcinoma tissues and review previous literature to achieve optimal treatment better prognosis. Case Presentation. 60-year-old woman presented with growing mass at left side...
Seprafilm is an ideal synthetic adhesion barrier, but its insertion into the abdomen in laparoscopic surgery difficult because of stiff and brittle nature. We tested usefulness a novel technique moistening before use to increase flexibility through trocar during surgery.Laparoscopic pelvic surgeries that were followed by evaluated 67 women. A piece (1/6 or 1/4 size full sheet) was placed on gauze moistened with saline solution soften it. The prepared then rolled, inserted forceps 12-mm port,...
Endometriosis is an estrogen-dependent disease, and estrogen overproduced by abnormally elevated aromatase in endometriotic tissues. Peroxisome proliferator-activated receptor gamma, coactivator 1α (PGC-1α) a transcriptional coactivator-modulating steroid hormone. To investigate the effect of PGC-1α on activity endometriosis. Specimens from ovarian endometrioma (OE), endometrium with endometriosis (EE), normal (NE) were analyzed for expression. PGC-1α-dependent changes expression primary...
Abstract Problem Regulatory T cells (Tregs) play important roles in diseases occurring women of reproductive age and pregnancy. Tregs are functionally heterogeneous can be divided into activated (aTregs), resting (rTregs), non‐suppressive (non‐Tregs). The purpose this study is to investigate the change Treg subpopulations during menstrual cycle early Method Two groups were enrolled: healthy aged 20 39 years with normal cycles patients scheduled undergo frozen‐thawed blastocyst transfer...
The epithelial ovarian carcinoma (EOC) is an aggressive malignant tumor, and currently the leading cause of gynecologic cancer death. CA125 most commonly used serum marker for EOC, but shows a high-false-positive rate several benign diseases such as endometriosis. purpose our study therefore to identify useful biochemical tool detecting qualitative differences between from patients with endometriosis facilitate differential diagnosis these diseases. In study, using two different...
The bovine gene encoding the type C atrial natriuretic peptide (ANP) receptor was isolated and characterized. appears to exist as a single copy in haploid genome is comprised of eight exons distributed over more than 85 kilobases. transcription start site identified by primer extension ribonuclease protection assay. A TATA box-like sequence found just upstream (at position -32); however, no CAAT box apparent. Exon boundaries ANP correlated well with functional domain protein; for example,...
Abstract Background Fetal skeletal dysplasia (FSD) comprises a complex group of systemic bone and cartilage disorders. Many FSD phenotypes have indistinct definitions, making definitive prenatal diagnosis difficult. The condition is typically diagnosed using sonography; however, three-dimensional computed tomography (3D-CT) also aids in diagnosis. This study aimed to examine the efficacy 3D-CT by comparing diagnostic accuracy fetal sonography 3D-CT. Methods On suspicion based on ultrasound...
Among diseases causing acute lower abdominal pain in women, isolated fallopian tube torsion is very rare, with an annual prevalence of 1 1.5 million. Because it has fewer findings on imaging compared to adnexal torsion, the correct diagnosis can rarely be made before operation. We present a case that was suspected preoperatively by its clinical course and computed tomography. A 24-year-old woman repeatedly experienced colicky right back. Transvaginal ultrasonography magnetic resonance showed...