A5007445460- Circadian rhythm and melatonin
- Endometriosis Research and Treatment
- Spaceflight effects on biology
- Uterine Myomas and Treatments
- Light effects on plants
- Genetics, Aging, and Longevity in Model Organisms
- Microbial Metabolic Engineering and Bioproduction
- Enzyme Catalysis and Immobilization
- Estrogen and related hormone effects
- Endometrial and Cervical Cancer Treatments
- Effects and risks of endocrine disrupting chemicals
- Cancer Treatment and Pharmacology
- Biofuel production and bioconversion
- Kruppel-like factors research
- IoT and Edge/Fog Computing
- Histone Deacetylase Inhibitors Research
- Software System Performance and Reliability
- Anorectal Disease Treatments and Outcomes
- Angiogenesis and VEGF in Cancer
- Photoreceptor and optogenetics research
- Ion Transport and Channel Regulation
- Porphyrin and Phthalocyanine Chemistry
- Protein Degradation and Inhibitors
- Context-Aware Activity Recognition Systems
- Ovarian cancer diagnosis and treatment
Nagoya University
2022
Kyoto Prefectural University of Medicine
2012-2020
Kyoto first Red Cross hospital
2020
Beckman Research Institute
2019
City of Hope
2019
Osaka University
2004-2018
Japanese Red Cross Society Kyoto Daini Hospital
2016
Tokyo Institute of Technology
2004-2014
Sony Corporation (United States)
2009-2013
Sony (Taiwan)
2004-2012
Abstract Background The circadian rhythm of about 24 hours is a fundamental physiological function observed in almost all organisms from prokaryotes to humans. Identification clock genes has allowed us study the molecular bases for behaviors and temporal processes such as hormonal secretion, prompted idea that clocks reside not only central pacemaker, suprachiasmatic nuclei (SCN) hypothalamus mammals, but also peripheral tissues, even immortalized cells. Furthermore, previous dissection...
In mammals, the circadian and stress systems (both centers of which are located in hypothalamus) involved adaptation to predictable unpredictable environmental stimuli, respectively. Although interaction relationship between these two intriguing have been studied different ways since "pre-clock gene" era, molecular them remains largely unknown. Here, we show by systematic biological analysis that acute physical elevated only Period1 (Per1) mRNA expression mouse peripheral organs. behavioral...
The circadian expression of the mammalian clock genes is based on transcriptional feedback loops. Two basic helix-loop-helix (bHLH) PAS (for Period-Arnt-Sim) domain-containing activators, CLOCK and BMAL1, are known to regulate gene by interacting with a promoter element termed E-box (CACGTG). non-canonical E-boxes or E-box-like sequences have also been reported be necessary for oscillation.We report new cis-element required cell-autonomous transcription genes. This consists canonical an...
A thorough understanding of the circadian clock requires qualitative evaluation gene expression. Thus far, no simple and effective method for detecting human expression has become available. This limitation greatly hampered our rhythm. Here we report a convenient, reliable, less invasive using biopsy samples hair follicle cells from head or chin. We show that phase in accurately reflects individual behavioral rhythms, demonstrating this strategy is appropriate evaluating peripheral clock....
Abstract Menopause is a critical window of susceptibility for its sensitivity to endocrine disrupting chemicals due the decline endogenous estrogen. Using surgical menopausal (ovariectomized) mouse model, we assessed how mammary tissue was affected by both 17β-estradiol (E2) and polybrominated diphenyl ethers (PBDEs). As flame retardants in household products, PBDEs are widely detected human serum. During physiologically-relevant exposure E2, enhanced E2-mediated regrowth glands with...
Aquaporin-3 (AQP3) is unique in its structure (lowest homology with other aquaporins) and function (significantly conductive to both small nonelectrolytes water). However, there a controversy among researchers on water transport induction by dehydration. We examined localization the effect of dehydration expression kidney, as well channel activity when expressed Xenopus oocytes. In vitro translation using reticulocyte lysate revealed that size rat AQP3 was 26 kDa, band shifted around 31 kDa...
UV radiation causes a number of harmful events including growth delay, cell death and ultimately cancer. The reversal such effects by concomitant exposure to visible light is conserved mechanism which has been uncovered in many multi-cellular organisms. Here we show that light-dependent UV-tolerance autonomous phenomenon zebrafish. In addition, provide several lines evidence indicating induction 64PHR, DNA repair enzyme, the subsequent mediated this enzyme are prerequisites for...
Estrogen-related receptor (ERR)α presents structural similarities with estrogen (ER)α. However, it is an orphan not binding to naturally occurring estrogens. This study was designed investigate the role of ERRα in endometrial cancer progression. Immunohistochemistry analysis on 50 specimens from patients showed that expressed all examined tissues and elevated expression levels were associated advanced clinical stages serous histological type (p < 0.01 for each). knockdown siRNA suppressed...
Polybrominated diphenyl ethers (PBDEs) have been used as flame retardants in household materials. Their environmental persistence has led to continuous human exposure and significant tissue levels. Three PBDE congeners (BDE-47, BDE-100, BDE-153) frequently detected serum. Although these compounds appear possess endocrine disrupting activity, studies are largely missing determine the biological mechanisms of PBDEs breast cancer cells. Here, we assessed bioactivities with three complementary...
AF-6/afadin plays an important role in the formation of adherence junctions. In breast and colon cancer, loss induces cell migration invasion. We aimed to elucidate human endometrial cancer. Morphology expression cancer lines was investigated by 3-dimensional culture. used Matrigel invasion assay demonstrate knockdown induced invasive capability. Cell proliferation performed estimate chemoresistance doxorubicin, paclitaxel cisplatin knockdown. The associations between clinicopathological...
<h3>Objective</h3> Estrogen-related receptors (ERRs) are orphan nuclear that modulate the estrogen receptor (ER)-mediated pathway and play roles in regulation of breast prostate cancer cell growth. However, significance localization function ERRs uterine endometrial remain unclear. We aimed to measure expression ERRγ determine its association with ER-mediated human cancer. <h3>Methods</h3> Proliferation, luciferase, quantitative polymerase chain reaction assays were performed ERα-positive...
Introduction. The incidence of endometriosis affecting skin tissue represents only 0.5-1.0% all cases. A malignancy in the abdominal wall arising from following cesarean section is even rarer; 21 cases have previously been reported. therapeutic strategy has not determined because limited We report a case clear cell adenocarcinoma tissues and review previous literature to achieve optimal treatment better prognosis. Case Presentation. 60-year-old woman presented with growing mass at left side...
Although out-of-lab investigation of the human circadian clock at gene expression level remains difficult, a recent method using hair follicle cells might be useful. While exercise may function as an entrainment cue for rhythms, it unclear whether affects expression.Efforts to observe apparent effects on require that several specific conditions met: intense should habitually performed relatively uncommon time day over extended period; and any relative phase shift thereby observed validated...
The rhythmic recurrence of biological processes is driven by the functioning cellular circadian clocks, operated a set genes and proteins that generate self-sustaining transcriptional-translational feedback loops with free-running period about 24 h. In gastrointestinal apparatus, clocks shows distinct patterns in different organs. aim this study was to evaluate time-related variation clock gene expression mouse liver stomach, two components digestive system sharing vascular autonomic supply,...
A novel high-pressure molybdenum nitride phase, Mo3N5, was synthesized at above 45 GPa via a nitridation reaction of with nitrogen under high pressure using laser-heated diamond anvil cell. having an N-N dimer and 7-coordinated Mo sites, crystallizes in orthorhombic structure space group Cmcm (No. 63) without other prototype structures. The refined lattice parameters for Mo3N5 were = 2.86201(2) Å, b 7.07401(6) c 14.59687(13) Å. DFT enthalpy calculation suggested that is stable which also...
A new supramolecular chirogenic system on the basis of tetrakis(nickel porphyrin) and various enantiopure solvents, which was specifically designed for investigation phenomenon upon extremely weak interaction modes marginal chiroptical responses, is reported. The temperature found to be a key factor controlling chirality transfer process in these assemblies.
•Metastases from extrapelvic organs to the uterine cervix are rare.•Cervical metastases stomach often accompanied by extrauterine metastases.•We report a case of cervical metastasis gastric cancer, occurring 10 years after first surgical treatment.