A5017554741- Estrogen and related hormone effects
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Cancer Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Testicular diseases and treatments
- Drug-Induced Adverse Reactions
- Ureteral procedures and complications
- Eosinophilic Disorders and Syndromes
- Cardiac tumors and thrombi
- Autoimmune and Inflammatory Disorders
- Sarcoma Diagnosis and Treatment
- Pelvic floor disorders treatments
- BRCA gene mutations in cancer
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Lung Cancer Research Studies
- PARP inhibition in cancer therapy
- Vascular Tumors and Angiosarcomas
- Cervical Cancer and HPV Research
- Breast Lesions and Carcinomas
- Intestinal and Peritoneal Adhesions
- Urinary and Genital Oncology Studies
Kyoto Prefectural University of Medicine
2016-2024
Abstract Estrogen-related receptor alpha (ERRα), which shares structural similarities with estrogen receptors, is associated tumor progression in endometrial cancer, but little known about the detailed underlying mechanism. We investigated whether ERRα, cooperation peroxisome proliferator-activated gamma coactivator 1-alpha (PGC-1α), could participate epithelial-mesenchymal transition (EMT) cancer through cancer-stromal interactions. Two cell lines, Ishikawa and HEC-1A, transfected...
Estrogen-related receptor (ERR)α presents structural similarities with estrogen (ER)α. However, it is an orphan not binding to naturally occurring estrogens. This study was designed investigate the role of ERRα in endometrial cancer progression. Immunohistochemistry analysis on 50 specimens from patients showed that expressed all examined tissues and elevated expression levels were associated advanced clinical stages serous histological type (p < 0.01 for each). knockdown siRNA suppressed...
This study aimed to evaluate the efficacy and safety of computed tomography-magnetic resonance imaging (CT-MRI)-guided multi-catheter interstitial brachytherapy for patients with bulky (≥4 cm) high-risk, stage IIB–IVB advanced cervical cancer. Eighteen who underwent concurrent chemoradiotherapy between September 2014 August 2020 were enrolled. The prescribed dose external beam radiotherapy was 45–50.4 Gy, high-dose-rate aim 25–30 Gy per 5 fractions. endpoints four-year local pelvic control...
Abstract Progesterone is used to treat uterine endometrial cancer in young patients wishing preserve their fertility as well advanced or recurrent patients, but its response rate limited. The antitumor effect of progesterone mediated by receptor (PR) binding. Hence, loss progesterone’s therapeutic effect, i.e., development resistance, mainly due decreased PR expression. However, little known about underlying mechanisms that regulate Immunohistochemistry analysis specimens from 31 young,...
Abstract Introduction Hypersensitivity reactions (HSRs) to chemotherapy are serious adverse events associated with cancer drug therapy and can occur any antitumor drug. This study investigated the safety efficacy of carboplatin desensitization in Japan established a method for treating HSRs. Methods Patients diagnosed gynecological (ovarian, endometrial, or cervical) cancers who underwent between 2016 2020 at Gynecologic Cancer Study Group Clinical Oncology were included. The each...
Diagnostic laparoscopy is useful in the management of gynecological cancers; however, it can occasionally result detection other malignancies. Occult breast cancer (OBC) metastatic without a recognized primary lesion. We report rare case OBC that was detected laparoscopically. A 64-year-old female presented to our hospital with back pain. Magnetic resonance imaging (MRI) revealed 50 mm multicystic tumor an internal nodule right ovary. Positron emission tomography/computed tomography showed...
The clinical outcomes in patients with ovarian cancer have been significantly improved by Poly(adenosine diphosphate–ribose) polymerase inhibitors (PARP-is). However, the best therapeutic strategy for recurrence during PARP-i maintenance therapy remains unknown. Herein, we elucidated efficacy of platinum-based chemotherapy after treatment recurrent cancer. Eligible had experienced relapses lasting at least 6 months and received subsequent our institution between January 2019 March 2024....
Malignant struma ovarii (MSO) is an extremely rare disease arising from ovarii. Preoperative diagnosis still challenging due to the lack of criteria for imaging findings. Herein, we report a case MSO with suggestive findings 50-year-old woman who presented pelvic tumor. The tumor did not typically show characteristic ovarii; however, implied colloids thyroid tissue within solid components on magnetic resonance (MRI) and computed tomography. Additionally, showed hyperintensity...
Retroperitoneal liposarcoma is a rare tumor, and its dedifferentiated subtype larger diameter are associated with poor prognosis. However, there few reports of retroperitoneal liposarcomas, both >30 cm. We report case giant subtype. A 78-year-old woman presented to our hospital abdominal distension loss appetite. Computed tomography magnetic resonance imaging findings revealed 35-cm-diameter solid tumor in the peritoneal cavity. CA125 (64.8 U/mL) HE4 (229.0 pmol/L) were elevated...
Desensitization protocols of platinum-based agents are recommended for patients with a history hypersensitivity reaction (HSR). Herein, we report the first case successful desensitization therapy nedaplatin after HSR to carboplatin and platinum-sensitive recurrent ovarian cancer. A 53 year-old woman was diagnosed stage IIIC serous carcinoma ovary underwent primary debulking surgery followed by an adjuvant chemotherapy. The tumor relapsed 4 times in 10 years initial treatment, chemotherapy...
Abstract Ovarian carcinosarcoma in hereditary breast and ovarian cancer syndrome is rare. A 43‐year‐old woman with a family history of prostate uterine or had an 8‐cm mass the right ovary. Although computed tomography suggested peritoneal dissemination to Douglas pouch, she wanted preserve her fertility; therefore, underwent salpingo‐oophorectomy. Histopathological diagnosis was consisting high‐grade serous carcinoma sarcomatous components, including cartilage. Three weeks later, radical...
Abstract Laparoscopic surgery has become the gold standard treatment for endometriosis. Surgical of deep endometriosis with colorectal involvement is challenging. It requires complete surgical excision lesions despite a high risk complications that include rectal injury, rectovaginal fistula and pelvic abscess. An intraoperative air leak test allows detection injury reduces postoperative complications. We report case successful management during laparoscopic using probe even though tests...
While cancer cure is the primary goal, fertility preservation also a cornerstone of underlying principle treatment for ovarian germ cell tumors. Growing teratoma syndrome (GTS) presents with growth mature teratomas during or after chemotherapy. We report case successful GTS in anterior abdominal wall involving reconstruction. A 23-year-old woman suspected right torsion underwent emergency laparoscopically assisted extracorporeal cystectomy. Histopathological findings revealed grade 1...
<h3>Introduction</h3> Locally advanced cervical cancers with bulky and asymmetrical tumors treated intracavitary brachytherapy are more likely to relapse in a few years due insufficient dose prescription the entire tumor, resulting poor prognosis. The purpose of this study is evaluate efficacy safety 3-dimennsional (3D) image-guided multi-catheter interstitial brachytherapy, which could increase flexibility distribution for patients (≥4 cm) high-risk, stage IIB-IVA cancer. <h3>Methods</h3>...