Background: During recent decades, multipotent stem cells were found to reside in the adipose tissue, and these adipose-derived shown play beneficial roles, like those of Schwann cells, peripheral nerve regeneration. However, it has not been well established whether offer effects injuries vivo as do. Furthermore, situ survival differentiation after transplantation at injured tissue remain be fully elucidated. Methods: Adipose-derived transplanted with gelatin hydrogel tubes artificially...

Adipose-derived stem cells (ADSCs) are attracting increased attention as a novel source in regenerative medicine. Transplantation of ADSCs promotes functional recovery animal models peripheral nerve injury, but the mechanism enhanced regeneration remains to be elucidated. In addition, it is important examine whether supportive functions dependent on donor age or anatomic site origin. this study, we examined effects factors produced by mouse Schwann (SCs) and dorsal root ganglion (DRG)...

Abstract Schwann cells (SCs) play pivotal roles in the maintenance and regeneration of peripheral nervous system. Although transplantation SCs enhances repair experimentally damaged central nerve tissues, it is difficult to prepare a sufficient number functional for therapy without causing adverse events donor. Here, we generated by somatic cell reprogramming procedures demonstrated their capability promote regeneration. Normal human fibroblasts were phenotypically converted into transducing...

Recent studies have shown that adipose-derived stromal/stem cells (ASCs) contain phenotypically and functionally heterogeneous subpopulations of cells, but their developmental origin relative differentiation potential remain elusive. In the present study, we aimed at investigating how to what extent neural crest contributes ASCs using Cre-loxP-mediated fate mapping. harvested from subcutaneous fat depots either adult P0-Cre/or Wnt1-Cre/Floxed-reporter mice contained a few crest-derived...

Surgical cutting guides are used in mandibular reconstruction involving osteotomy of the mandible and fibula. Cutting produced using computer-aided design (CAD) manufacturing (CAM) technologies have been reported recently. These aim to increase benefits patients by improving accuracy, shortening operating time, correcting occlusion. However, availability these advanced is limited some regions world. To test whether we could produce low-cost surgical guides, made investigated their...

The pedicled, descending-branch muscle-sparing latissimus dorsi (MSLD) flap has been widely used for breast reconstruction following total mastectomy. However, the superiority of MSLD compared to conventional (CLD) in preventing seroma formation not demonstrated. This study compares morbidities related pedicled and CLD reconstruction.A 15 women who underwent partial mastectomy immediate with flaps were under identical conditions reconstruction. medical records reviewed both complications...

Intravenous heparin administration is used to prevent thrombosis in free-flap transfer. However, it unknown whether the use of affects survival. The purpose this study investigate effect free flap transfer.Two hundred and six patients who received ablative surgery for head neck cancer were classified into three groups. Group A surgery, dissection, reconstruction, postoperatively they administered continuous intravenous unfractionated (5000-10 000 units/day) until postoperative day 7 (POD7);...

Abstract Keloids are fibroproliferative diseases characterized by the accumulation of an extracellular matrix including collagen. Various growth factors, or cytokines, and their receptors overexpressed in keloids, they expected to be therapy targets. Sulforaphane, a dietary isothiocyanate, has recently shown anti‐tumor, anti‐inflammatory, anti‐fibrotic properties. In this study, we found that sulforaphane inhibited cell reduced collagen at mRNA protein levels keloid fibroblasts. Moreover,...

Platelet-rich plasma contains high concentrations of growth factors that stimulate proliferation and migration various cell types. Earlier experiments demonstrated local platelet-rich administration activates Schwann cells to improve axonal regeneration at a transected peripheral nerve lesion. However, the optimal concentration human for activation has not been determined, mechanisms by which remain be clarified.

Abstract To clarify whether a supercharged free jejunal transfer would have different clinical outcome from the usual method, we examined data cases of esophago‐pharyngeal reconstruction. Fifty‐three patients in whom hypopharynx and cervical esophagus was reconstructed with were divided into two groups: 19 normal procedures 34 supercharged. Clinical outcomes including intraoperative postoperative events, complications deglutition compared statistically. There no significant differences...

Capsular contracture around implants is a common complication after breast reconstruction. Strain elastography (STE) and shear-wave (SWE) are noninvasive imaging techniques that can measure tissue stiffness thickness of the capsule.The purposes study were to compare STE SWE for measurement capsular implant reconstruction using intra-class correlation coefficients (ICCs) investigate these data with Baker score, which most frequently used clinical staging scale capsule contracture.The subjects...

Chronic pain after breast surgery including reconstruction is a major concern for patients. However, the factors associated with chronic are uncertain in Japanese population. The aim of this study was to identify patient-specific and medical/surgical that predict subjects were 189 women undergoing tissue expander/implant (TE/implant), deep inferior epigastric perforator (DIEP) procedures mastectomy only. Pain assessed at one year postoperatively using validated survey instrument: version...

Abstract Mandibular reconstruction using computer-aided design and computer-assisted manufacturing (CAD/CAM) techniques has received recent attention. This technique theoretical advantages, although this approach can be commercially used in the limited area of world. The aim is to describe our experience in-house CAD/CAM guides situations which may present benefit region where commercial are unavailable. authors developed In-house for mandibular reconstructions with a free fibular flap....

Abstract In this report, we present a case in which free anterolateral thigh (ALT) flap was transferred for head and neck reconstruction after oropharyngeal cancer ablation, retrograde arterial inflow used to salvage the when main pedicle showed usual repeated spasms. The raised as chimera comprising fasciocutaneous vastus lateralis muscle flap. After reperfusion, artery exhibited spasms repeatedly vascular flow unstable. Therefore, performed supercharge. distal portion of flap, small branch...

Postoperative seroma is still the main complication after a latissimus dorsi (LD) flap procedure. The etiology of currently thought to comprise tissue fluids resulting from inflammatory reactions in affected caused by use monopolar electrocautery (EC). It possible that formation can be reduced using alternative devices such as PEAK PlasmaBlade (PPB), which provides atraumatic scalpel-like cutting precision while blade temperature remains close body temperature. subjects were 44 patients who...

Sir, Machine learning is expected to help humans evolve even in the field of plastic surgery.1 However, surgeons must be aware that artificial intelligence (AI) could create a biased view on patients, instead promoting objectivity. One comprehensive example AI for measurement facial attractiveness based semisupervised machine learning.1,2 At beginning procedure, researchers give scores portraits famous actors and actresses as group most beautiful faces. Subsequently, memorizes combinations...