A5054335379- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Colorectal and Anal Carcinomas
- Gestational Trophoblastic Disease Studies
- Lung Cancer Research Studies
- Genital Health and Disease
- Maternal and fetal healthcare
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Reproductive Biology and Fertility
- Prenatal Screening and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Ectopic Pregnancy Diagnosis and Management
- Gynecological conditions and treatments
- Pregnancy and preeclampsia studies
- T-cell and Retrovirus Studies
- Maternal and Perinatal Health Interventions
- Sperm and Testicular Function
- Renal cell carcinoma treatment
- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
Osaka International Cancer Institute
2016-2025
Osaka City University
2005
Osaka University
1987-1997
Rohto Pharmaceutical (Japan)
1994
Columbia University Irving Medical Center
1990-1992
New York University
1990-1992
Kaplan (United States)
1990
Fukushima Medical University
1988
BACKGROUND: Intraperitoneal chemotherapy has been shown to be effective at reducing mortality for patients with advanced epithelial ovarian cancer but is not widely used in practice. METHODS: We performed the Therapy Ovarian Cancer Carboplatin (iPocc) trial as an open-label, international, multi-institutional, randomized phase 2/3 clinical women newly diagnosed who underwent laparotomy or laparoscopy. All received intravenous paclitaxel (80 mg/m2 on days 1, 8, and 15 of a 21-day cycle). In...
To investigate the clonality of uterine leiomyomas, we developed a PCR-based method involving differential inactivation X-chromosome-linked phosphoglycerokinase (PGK) gene. Small DNA samples 22 leiomyomas from 9 Japanese patients, showing heterozygosity at BstXl site PGK gene, were digested with methylation-sensitive restriction enzyme HpaII. Only inactive (methylated) gene allele was selectively amplified by PCR followed digestion and electrophoresis. All leiomyoma consisted single type...
To identify groups of patients who derive clinical benefit from postoperative adjuvant concurrent chemoradiotherapy (CCRT), we retrospectively investigated the survival outcomes surgically treated early-stage cervical cancer patients.We reviewed medical records 316 with FIGO stage IB1-IIB had been radiotherapy (RT) (n = 124, RT group) or CCRT 192, after radical hysterectomy between January 1996 and December 2009. Of these, 187 displayed high-risk prognostic factors (high-risk group), 129...
This was the first large-scale prospective observational Japanese study evaluating safety and efficacy of bevacizumab combined with paclitaxel carboplatin for newly diagnosed advanced ovarian cancer. Patients were prospectively enrolled in primary analysis cohort if they had Stage III or IV epithelial ovarian/fallopian tube/primary peritoneal cancer scheduled to receive plus every 3 weeks Cycles 1–6 2–22. Primary endpoints bevacizumab-specific adverse events ≥ Grade 3. Secondary...
Oxytocin (OT) is widely used to induce labor in the clinical setting. However, its physiological role normal human parturition remains unclear. We demonstrated enhanced expression of OT receptor (OTR) mRNA chorio-decidual tissue, using polymerase chain reaction after reverse transcriptase (RT-PCR) and Northern blot analysis. OTR gene tissue increased fivefold during course parturition. In situ hybridization fetal membrane revealed maternally derived decidual cells. The was also detected...
Several molecular targeting drugs are being evaluated for endometrial cancer; selecting patients whose cancers sensitive to these agents is of paramount importance. Previously, we developed the cancer tissue-originated spheroid method primary cells taken from patients' tumors as well patient-derived xenografts. In this study, successfully prepared and cultured spheroids cancers. Characteristics original were retained in including morphology expression p53 or neuroendocrine markers. We...
Interim results from the two-cohort, phase 2 KEYNOTE-100 study (NCT02674061) of 376 patients with previously treated advanced recurrent ovarian cancer (ROC) showed that pembrolizumab monotherapy was associated an objective response rate (ORR) 8.0% (95% CI, 5.4-11.2). We present outcomes for Japanese (n = 21) enrolled in KEYNOTE-100. Patients epithelial ROC had received either 1-3 prior chemotherapy lines and platinum-free interval or treatment-free (PFI; TFI) 3-12 months (cohort A) 4-6...
The incidence of ovarian metastases from colorectal cancers (CRCs) has been reported to occur in 3-8% CRC patients, and the prognosis for patients is very poor. We assessed clinicopathological characteristics with metastasis significance resection metastases.We retrospectively analyzed 22 metastases. Synchronous occurred 8 metachronous 14 patients. Peritoneal dissemination was observed nine patients.The mean follow-up period 45.3 months. overall survival at 3 years following diagnosis...
Cisplatin is an effective chemotherapeutic agent for ovarian cancer, but the sensitivity of cancers differs in individual cases. Because cisplatin reported to suppress glucose uptake, we investigated correlation between uptake and drug. A fluorescent derivative D‐glucose, 2‐NBDG (2‐[N‐(7‐nitrobenz‐2‐oxa‐1,3‐diaxol‐4‐yl) amino]‐2‐deoxyglucose), was used evaluate uptake. Two cancer cell lines, SKOV‐3 as a relatively resistant line OVCAR‐3 sensitive line, were analyzed. Both lines had decreased...
To elucidate oncogenic human papilloma virus (HPV) types in Japan, HPV genotyping was performed 1526 cervical intraepithelial neoplasia (CIN) and 371 invasive cancer (ICC) patients with the novel Genosearch-31+5 test. The HPV-positive rates were 89.3% 90.8% CIN ICC. Regarding single-type infections, 13 internationally recognized high-risk (13HR) excluding 35, probably HR 53, 67, 69, 70 identified ICC, suggesting that all these may be oncogenic. HPV16 18 both SCC adenocarcinoma (ADC). HPV52,...
This study seeks to identify risk factors associated with ovarian metastasis and characterize a population minimum of in young women stage IB-IIB cervical cancer. was nation-wide multicenter retrospective Japan examining consecutive cases surgically-treated clinical cancer who had oophorectomy at radical hysterectomy (n = 5,697). Multivariable analysis performed independent for metastasis. Ovarian seen 70 (1.2%, 95% confidence interval 0.9-1.5) cases. In the entire cohort, adenocarcinoma,...
We investigated the efficacy and safety of further bevacizumab therapy in patients with platinum-resistant ovarian cancer whose disease had progressed after plus chemotherapy. In this multicenter, open-label, phase II trial (JGOG3023), were randomized 1:1 to a single-agent chemotherapy alone (either pegylated liposomal doxorubicin [40 or 50 mg/m2 administered intravenously], topotecan [1.25 paclitaxel [80 gemcitabine [1000 intravenously]) + (15 intravenously). The primary endpoint was...
We investigated clinical implications of CRP and its receptor, LOX-1, in cervical cancer progression the underlying mechanisms. Clinical data from 121 patients with administered definitive radiotherapy were analyzed to investigate relationship among pretreatment serum levels, tumor LOX-1 expression, treatment outcomes. samples, cell lines, mouse xenograft models employed elucidate mechanisms for CRP-mediated cancer, focusing on expression myeloid-derived suppressor (MDSCs) cells. Patients...