A5070252265- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Multiple and Secondary Primary Cancers
- Family Support in Illness
- Social Media in Health Education
- Genital Health and Disease
- Gynecological conditions and treatments
- Reproductive System and Pregnancy
- Growth Hormone and Insulin-like Growth Factors
- Reproductive tract infections research
- Cancer-related Molecular Pathways
- Cancer Risks and Factors
- Management of metastatic bone disease
- Cancer survivorship and care
- Hepatitis B Virus Studies
- Pregnancy and preeclampsia studies
- Urinary and Genital Oncology Studies
- Colorectal and Anal Carcinomas
- Focus Groups and Qualitative Methods
- Pelvic floor disorders treatments
- Childhood Cancer Survivors' Quality of Life
St. Luke's International Hospital
2024-2025
Nihon University
2019-2024
Kanagawa Prefectural Hospital Organization
2018-2024
Kanagawa Cancer Center
2018-2024
Yokohama City University
2011-2020
Nihon University Itabashi Hospital
2019-2020
Tokyo University of Science
2015-2018
Tokyo Women's Medical University Hospital
2015-2018
Yokohama City University Hospital
2014-2017
Yokohama Municipal Citizen's Hospital
2004-2010
This was the first large-scale prospective observational Japanese study evaluating safety and efficacy of bevacizumab combined with paclitaxel carboplatin for newly diagnosed advanced ovarian cancer. Patients were prospectively enrolled in primary analysis cohort if they had Stage III or IV epithelial ovarian/fallopian tube/primary peritoneal cancer scheduled to receive plus every 3 weeks Cycles 1–6 2–22. Primary endpoints bevacizumab-specific adverse events ≥ Grade 3. Secondary...
Abstract Purpose To investigate the impact of adenomyosis on complications and outcomes pregnancy in Japan. Methods We carried out a multicenter retrospective questionnaire survey. A regarding was sent to 725 facilities. Results Data were obtained cases 272 pregnant women with from 65 The included miscarriage before 12 weeks (14.8%), after (9.9%), preterm delivery (24.4%), fetal growth restriction (11.8%), pregnancy‐induced hypertension intrauterine infection (7.3%), cervical incompetency...
Adiponectin is an adipocyte-derived hormone involved in glucose, lipid and energy metabolism. A low plasma adiponectin concentration associated with insulin resistance, obesity atherosclerosis. In women, homeostasis remarkably changed during gestation lactation order to supply sufficient nutrition for a fetus or newborn. this study we aimed elucidate the physiological impact of on levels influence reproduction-related hormones secretion. We studied longitudinal changes pregnancy (1st, 2nd...
Objective: In Japan, the possible adverse events upon HPV vaccination was widely reported in media. MHLW announced suspension of aggressively encouraging 2013, and inoculation rate has sharply declined. The aim present study estimation future cervical cancer risk.Methods: latest data on at each age Sakai City were first investigated. experiencing sexual intercourse 12, 13, 14, 15, 16, 17 throughout lifetime is assumed to be 0%, 1%, 2%, 5%, 15%, 25%, 85% respectively. risk regarded...
Ovarian clear cell adenocarcinoma (CCC) is the second most common subtype of ovarian cancer after high-grade serous adenocarcinomas. CCC tends to develop resistance standard platinum-based chemotherapy, and has a poor prognosis when diagnosed in advanced stages. The ANXA4 gene, along with its product, Ca++-binding annexin A4 (ANXA4) protein, been identified as signature gene. We reported two subtypes different isoelectric points (IEPs) that are upregulated lines. Although several vitro...
Abstract Aim This study aimed to assess the awareness of concept “cardio‐oncology” and cardiovascular disease (CVD) in patients with endometrial cancer (EC) among Japanese Gynecologic Oncology Group members. Methods An online anonymous survey, which consisted questions about respondent attributes cardio‐oncology, was conducted twice, 2022 2024. During these surveys, guidelines for treatment uterine body neoplasm were published July 2023. Results In 2022, significantly numerous physicians...
Abstract Aim A multicenter, retrospective survey was conducted in order to investigate the current clinical status of adenomyosis Japan. Methods The questionnaires covered management infertile women with and outcomes infertility treatment adenomyosis. were sent 1149 facilities Results data obtained on 535 from 190 facilities. Regarding management, performed without pretreatment for 37 facilities, after medication eight an operation four Management policies not established 106 outcomes,...
Abstract Background Although many human papillomavirus (HPV)–targeted therapeutic vaccines have been examined for efficacy in clinical trials, none translated into use. These previous agents were mostly administered by intramuscular or subcutaneous injection to induce systemic immunity. We investigated the safety and of an HPV-16 E7-expressing lacticaseibacillus-based oral vaccine. Methods In a double-blind, placebo-controlled, randomized trial, total 165 patients with HPV-16–positive...
Cervical cancer (CC) incidence and mortality among young women have been increasing in Japan. To develop effective measures to combat this, we assessed the feasibility of using a social networking site (SNS) recruit representative sample conduct knowledge attitude study about CC prevention via an internet-based questionnaire.From July 2012 March 2013, advertising banners targeting aged 16 35 years Kanagawa Prefecture were placed on Facebook similar manner as Australian (AUS) conducted 16-...
In this study, we compared the long-term effects of neonatal exposure to diethylstilbestrol (DES, 0.0125-50 microg), tamoxifen (TAM, and toremifene (TOR, 53 microg) on mammary gland development differentiation. Allometric growth ducts was stimulated by DES (12.5 impaired TAM (25 microg). Neonatal treatment with high doses resulted in that displayed extensive dilatation precocious lactogenesis postpubertal, nulliparous females. Initiation differentiation coincided absence corpora lutea,...
Prolactin, a peptide hormone essential for the development and function of reproductive organs, is involved in breast, prostate colorectal cancers. However, role prolactin on carcinogenesis ovarian carcinomas unclear. In this study, we show that mRNA receptor expressed 5 out 9 carcinoma cell lines, 15 17 cases surgical samples all normal surface epithelium, while transcript detected only 1 line samples. For receptor-positive cells, exogenous did not affect proliferation but markedly...
Abstract Aim: The goal of the current study was to determine anxiety level and prevalence psychiatric disorders among patients awaiting surgery for ovarian tumors. Also analyzed were predictive factors changes after surgical diagnosis. Methods: Patients who underwent tumors examined before with MINI International Neuropsychiatric Interview, Spielberger State‐Trait Anxiety Inventory (STAI) Mausley Personality (MPI). Participants diagnosed cancer a third time being given an explanation about...
This is a concept paper of multicenter, placebo-controlled, double-blind randomized phase I/II trial to test the safety and efficacy IGMKK16E7 for patients with HPV16-positive high-grade squamous intraepithelial lesion.
To determine the role of radiation therapy for patients with bone metastasis from uterine cervical cancer and identify an optimal regimen.A total 20 metastases received to pelvis. The median dose 60.2 Gy in 2 per fraction-equivalent (EQD2) was delivered tumors all patients. Thirteen underwent chemotherapy during and/or following therapy.In 18 patients, primary disappeared or were markedly reduced after therapy. In but one 17 pelvic pain bleeding, these symptoms remarkably relieved. However,...
Atypical protein kinase C λ/ι (aPKCλ/ι) is a regulator of epithelial cellular polarity. It also overexpressed in several cancers and functions cell proliferation invasion. Therefore, we hypothesized that aPKCλ/ι may be involved development progression cervical intraepithelial neoplasia (CIN), the precancerous disease cancer induced by human papillomavirus. To do this, investigated relationship between expression CIN. level subcellular localization were assessed 192 CIN biopsy samples 13...
The human papillomavirus (HPV) vaccination rate in Japan fell to nearly 0% following widespread coverage of possible adverse events. Developing a next approach promote the effective prevention HPV-related diseases including cervical cancer (CC) requires comprehensive understanding knowledge and attitudes regarding CC prevention, HPV infection among population laypersons medical professions Japan.A questionnaire survey was administered wide variety settings Japan. contained items on about CC,...
In Japan, the trend for cervical cancer at younger ages has been increasing. As a countermeasure, HPV vaccine was introduced as routine vaccination in April 2013. However, Ministry of Health, Labour and Welfare (MHLW) announced "Suspension its active inoculation recommendation vaccine" June 2016, 32 months after that suspension, we conducted survey via Internet compared results with our previous ones 9 23 suspension (in 2014 2015, respectively). We examined 'time-dependent change' 'intention...
We carried out a retrospective review to determine the role played by radiation therapy in treatment of very elderly patients with uterine cervical cancer.Thirty aged 80 years and older squamous cell carcinoma cervix, at clinical stages IB-IVA, underwent therapy. Of these 30 patients, 6 received external irradiation alone 24 intracavitary brachytherapy. A total median dose 69.0 Gy (range, 45.6 75.4 Gy) was delivered tumors. No chemotherapy.At follow-up time months, 7 had developed...
To evaluate the safety and efficacy of radiation therapy for stage IVA uterine cervical cancer to identify an optimal regimen.Seventeen 28 patients developed recurrence after (local in 10 distant metastasis 12). The local control metastasis-free rates at 3 years all were 61% 49%, respectively. Fourteen died therapy, but 2 tumor progression. disease-free, cause-specific, overall survival 32%, 45%, respectively, estimated median time was 32 months. Tumor size (P = 0.007) involvement lower...
In Japan, the rate of cervical cancer screening is remarkably low, especially among women in their twenties and thirties, when now increasing dramatically. The aim this study was to test whether a modified government reminder for 20-year-old engage screening, acting through maternal education by asking recommendation daughter receive could increase participation rate.In two Japanese cities, girls who had not received first before October fiscal year 2014 were randomized into arms. One group...