A5008885403- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- BRCA gene mutations in cancer
- Hepatitis B Virus Studies
- Endometrial and Cervical Cancer Treatments
- Genetic factors in colorectal cancer
- Genital Health and Disease
- DNA and Nucleic Acid Chemistry
- Reproductive tract infections research
- Vaccine Coverage and Hesitancy
- Advanced biosensing and bioanalysis techniques
- PARP inhibition in cancer therapy
- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Genomics, phytochemicals, and oxidative stress
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Gastrointestinal Tumor Research and Treatment
- Cancer-related molecular mechanisms research
- Toxin Mechanisms and Immunotoxins
- Genomic variations and chromosomal abnormalities
- GDF15 and Related Biomarkers
- Gastrointestinal disorders and treatments
- Colorectal and Anal Carcinomas
- Glutathione Transferases and Polymorphisms
University of the Ryukyus
2024
Toyo University
2011-2024
Niigata University Medical and Dental Hospital
2014-2024
Niigata University
2014-2023
Hadassah Medical Center
2007-2023
Jikei University School of Medicine
2020
Nagaoka Red Cross Hospital
2010-2012
Beth Israel Deaconess Medical Center
2007-2010
Harvard University
2010
Tokyo Institute of Technology
1998-2009
Background While vascular endothelial growth factor (VEGF) expression in breast tumors has been correlated with a poor outcome the pathogenesis of cancer, expression, localization, and function VEGF receptors VEGFR1 (also known as FLT1) VEGFR2 KDR or FLK1), well neuropilin 1 (NRP1), cancer are controversial. Methods Findings We investigated cells. observed that was abundant, low, NRP1 variable. MDA-MB-231 MCF-7 cells, transfected antisense cDNA siVEGF (VEGF-targeted small interfering RNA),...
Abstract In 2013, recurrent reports of diverse symptoms occurring in girls after receiving HPV vaccination appeared Japanese media. The Ministry Health, Labor and Welfare quickly responded by announcing a temporary suspension its recommendation for the vaccine. rate soon fell to almost zero. present study, we calculated potential future numbers cervical cancer incidence death that will be increased this policy decision. We have assumed number yearly vaccinations is evenly distributed across...
Proactive recommendations for human papillomavirus (HPV) vaccines in Japan have been suspended 5 years because of safety concerns. While no scientific evidence exists to substantiate these concerns, one reason given not reinstating is the lack reliable vaccine effectiveness (VE) data a Japanese population. This study reports VE bivalent HPV women aged 20-22 years.During cervical screening between 2014 and 2016, had Papanicolaou smears tests performed provided about their sexual history....
Objective: In Japan, the possible adverse events upon HPV vaccination was widely reported in media. MHLW announced suspension of aggressively encouraging 2013, and inoculation rate has sharply declined. The aim present study estimation future cervical cancer risk.Methods: latest data on at each age Sakai City were first investigated. experiencing sexual intercourse 12, 13, 14, 15, 16, 17 throughout lifetime is assumed to be 0%, 1%, 2%, 5%, 15%, 25%, 85% respectively. risk regarded...
In Japan, recommendations for HPV vaccines were suspended in 2013 due to unfounded safety fears. Although vaccine opponents claim modifying sexual behavior can prevent cervical cancer, no comprehensive data exist on and the risk of high-grade disease a Japanese population. This study investigates infection 3968 women aged 20-41 yrs undergoing screening between April 2014 March 2016. Mean age at first intercourse was 18.4 ± 2.8 32% reported ≥ 6 lifetime partners. regression analyses, number...
Japan has no national vaccine registry and approximately 1700 municipalities manage the immunization records independently. In June 2013, proactive recommendations for human papillomavirus (HPV) were suspended after unconfirmed reports of adverse events following in media, despite safety signal having been raised. Furthermore, studies assessing HPV effectiveness published post suspension are predominantly based on self-reported information. Our aim was to examine accuracy vaccination status...
Abstract Aim Following media reports of adverse medical events surrounding human papillomavirus (HPV) vaccination and the suspension Japanese governmental recommendation, most adolescents have refrained from receiving vaccine. This represents a national critical event, because incidence cervical cancer in Japan continues to increase. Methods We conducted an Internet survey investigate why adolescent girls decline, continue or discontinue their HPV vaccination, how mothers influence decision,...
Cervical cancer has been increasing in younger generation, especially 20's and 30's, so it a serious problem that the disease leads to loss of fertility as an urgent issue Japan. HPV vaccine was added national list routine vaccinations for Japanese girls aged 12 16 years by law since April, 2013. Three months later, however, Ministry Health, Labour, Welfare suspended recommendations vaccination after several reports possible adverse events. We investigated rates 7-11th grade (ages 12to16...
Abstract Japan’s governmental recommendation of HPV vaccine has now been suspended for more than 4 years. In and before 2013, the targets 20-year-old cervical cancer screening were females born in 1993, i.e., those who could not have received vaccination because it was yet publicly introduced. The during 2014–2019 are, or will be, 1994–1999, came age a period with highest immunization rate. We analyzed statistical data each birth year, cumulative rates achieved as 16, corresponding results...
We have expressed our concern about HPV vaccination coverage in Japan remaining below 1%, which will result an increase vaccine-targeted infection rates and cervical cancer morbidity [1Simms KT Hanley SJB Smith MA Keane A Canfell K. Impact of vaccine hesitancy on Japan: a modelling study.The Lancet Public health. 2020; 5 (-e34): e223Summary Full Text PDF PubMed Scopus (81) Google Scholar, 2Ueda Y Yagi Ikeda S Enomoto T Kimura T. Beyond resumption the Japanese Government's recommendation...
Abstract We investigated characteristics of germline copy number variations (CNV) in BRCA1 ‐associated ovarian cancer patients by comparing them to CNVs present sporadic patients. Germline 51 ‐associated, 33 patients, and 47 healthy women were analyzed both signal intensity genotyping data using the Affymetrix Genome‐Wide Human SNP Array 6.0. The total per genome was greater group (median 26, range 12–34) than 21, 11–35; post hoc P < 0.05) or normal 20, 7–32; 0.05). While amplifications...
Sex‐determining region Y‐box 2 ( SOX 2) is an essential factor involved in the self‐renewal and pluripotency of embryonic stem cells has functions cell survival progression many types cancers. Here, we found that several endometrial cancer lines expressed 2, which was required for growth. Additionally, overexpression regulated expression cyclin‐dependent kinase inhibitor 1A CDKN ), specifically bound to p21 promoter DNA expressing 2. Expressions patients were significantly correlated with...
Malignancy during pregnancy has become a significant cause of maternal death in developed countries, likely due to both an older pregnant population, and increases cervical cancer younger women. Our aim is investigate the clinical aspects malignancy Japan use this information identify opportunities for earlier detection treatment.We provided questionnaire 1508 secondary or tertiary care hospitals Japan. We reviewed characteristics cases with period January December, 2008. From 760...
Abstract Cervical cancer remains among the most common cancers in women worldwide and can be prevented by vaccination. The Ministry of Health, Labour Welfare Japan suspended active recommendation regular human papillomavirus (HPV) vaccines 2013 because various symptoms including chronic pain motor impairment. This nationwide case‐control study from April to March 2017 targeted aged 20‐24 years old at cervical screening. We compared HPV vaccination exposure between those with abnormal normal...