A5091086591- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- PARP inhibition in cancer therapy
- Toxin Mechanisms and Immunotoxins
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Genital Health and Disease
- Hepatitis B Virus Studies
- Cancer Risks and Factors
- Intraperitoneal and Appendiceal Malignancies
- Reproductive tract infections research
- Gynecological conditions and treatments
- Cancer Mechanisms and Therapy
- Neuroendocrine Tumor Research Advances
- Testicular diseases and treatments
- Minimally Invasive Surgical Techniques
- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Multiple and Secondary Primary Cancers
Kindai University
2016-2025
Kindai University Hospital
2017
Abstract Homologous recombination repair (HRR) pathway deficiency (HRD) is involved in the tumorigenesis and progression of high-grade serous ovarian carcinoma (HGSOC) as well sensitivity to platinum chemotherapy drugs. In this study, we obtained data from The Cancer Genome Atlas (TCGA) on HGSOC identified scores for loss heterozygosity, telomeric allelic imbalance, large-scale state transitions, calculated HRD score. We then investigated relationships among score, genetic/epigenetic...
Tertiary lymphoid structures (TLS) are transient ectopic aggregates whose formation might be caused by chronic inflammation states, such as cancer. However, how TLS induced in the tumor microenvironment (TME) and they affect patient survival not well understood. We investigated distribution relation to infiltrating lymphocytes (TILs) related gene expression high-grade serous ovarian cancer (HGSC) specimens. CXCL13 correlated with presence infiltration of T cells B cells, it was a favorable...
Abstract Aim Open myomectomy (OM) was previously frequently performed; however, laparoscopic (LM) has recently become more common. Nevertheless, myoma can recur after both LM and OM. In this study, we report our retrospective investigation of recurrence by comparing Methods A total 474 patients underwent 279 The were followed‐up postoperatively from six months to eight years. Recurrence confirmed when a with diameter ≥ 1 cm detected. Post‐LM, post‐OM cumulative rates investigated, Cox hazard...
This phase III, multicenter, randomized, open-label study investigated the efficacy and safety of nivolumab versus chemotherapy (gemcitabine [GEM] or pegylated liposomal doxorubicin [PLD]) in patients with platinum-resistant ovarian cancer.
Endometrial cysts (ECs) are thought to be the origin of endometriosis-associated ovarian cancer (EAOC). A hypothesis that oxidative stress iron in causes "malignant transformation ECs" has been proposed, but this not verified. Several population-based studies showed endometriosis was a risk factor did reflect ECs". review most patients were diagnosed with EAOC early monitoring following detection ECs, and these cases might have from start. Epidemiologically, reduced by hysterectomy rather...
The efficacy of taxane plus platinum regimens has been demonstrated for advanced or recurrent endometrial cancer; however, it not assessed in postoperative adjuvant chemotherapy cancer.To evaluate the clinical benefit compared with standard doxorubicin cisplatin as cancer.In this multicenter, open-label, phase 3 randomized trial, patients cancer at high-risk stage I II III IV that did extend beyond abdominal cavity and had 2 cm greater residual tumor were included from 118 institutions Japan...
Objective: In Japan, the possible adverse events upon HPV vaccination was widely reported in media. MHLW announced suspension of aggressively encouraging 2013, and inoculation rate has sharply declined. The aim present study estimation future cervical cancer risk.Methods: latest data on at each age Sakai City were first investigated. experiencing sexual intercourse 12, 13, 14, 15, 16, 17 throughout lifetime is assumed to be 0%, 1%, 2%, 5%, 15%, 25%, 85% respectively. risk regarded...
Although bevacizumab has been used in the treatment of ovarian cancer, its optimal use is unknown.To investigate time-dependent changes outcomes therapy.This cohort study was conducted using published data from 7 previous randomized phase 3 clinical trials with (ICON7, GOG-0218, BOOST, GOG-0213, OCEANS, AURERIA, and MITO16B) January 10 to 31, 2023. From 2 ancillary analyses ICON7 trial individual patient tumor gene expression profiles, an ICON7-A generated comprising 745 cases. other...
To evaluate the detailed clinicopathologic characteristics of parametrial spread in uterine endometrial cancer.We retrospectively identified 334 individuals with cancer who had undergone radical hysterectomy between 1988 and 2007. Parametrial was determined by histopathological analysis surgically resected specimens.Twenty-eight (8.4%) histopathologically confirmed spread, lymphatic or blood vessel invasion (22 cases) most frequently observed type spread; direct to connective tissue (five...
Abstract The Japanese government began a human papillomavirus (HPV) vaccination program for girls aged 12‐16 years in 2010 but withdrew its recommendation 2013 because of potential adverse effects, leading to drastically reduced uptake. To evaluate population‐level effects HPV vaccination, women younger than 40 age newly diagnosed with cervical intraepithelial neoplasia grade 1‐3 (CIN1‐3), adenocarcinoma situ (AIS), or invasive cancer (ICC) have been registered at 21 participating institutes...
Somatic mutations in the ARID1A tumor-suppressor gene have been frequently identified ovarian clear cell carcinoma (CCC) cases. BAF250a encoded by is a member of SWI/SNF complex, but expression and mutation status other subunits not explored. The current study aimed to elucidate biological clinical significance complex subunits, assessing distinct genomic aberrations associated with their expression. Of 82 CCC specimens, 38 samples presented no expression, 50 exhibited loss at least one...