A5032494359- Endometrial and Cervical Cancer Treatments
- Protein Degradation and Inhibitors
- Chromatin Remodeling and Cancer
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Phagocytosis and Immune Regulation
- Cell death mechanisms and regulation
- Cancer-related gene regulation
- Sphingolipid Metabolism and Signaling
- Renal and related cancers
- Genital Health and Disease
- Curcumin's Biomedical Applications
- PARP inhibition in cancer therapy
- Epigenetics and DNA Methylation
- Uterine Myomas and Treatments
- Colorectal and Anal Carcinomas
- MicroRNA in disease regulation
- Reproductive tract infections research
- BRCA gene mutations in cancer
- Estrogen and related hormone effects
- Intraperitoneal and Appendiceal Malignancies
- Endometriosis Research and Treatment
- Galectins and Cancer Biology
- Angiogenesis and VEGF in Cancer
- RNA Interference and Gene Delivery
Tohoku University
2016-2025
Fred Hutch Cancer Center
2017-2023
Tohoku University Hospital
2019-2023
Sendai Medical Center
2021
National Hospital Organization
2021
Cancer Research Center
2019
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2019
Yamagata University
2015
Nerima General Hospital
2012
Institute of Applied Energy
1988
Plasminogen activator inhibitor (PAI)-1 is predictive of poor outcome in several types cancer. The present study investigated the biological role for PAI-1 ovarian cancer and potential targeted pharmacotherapeutics. In patients with cancer, mRNA expression tumor tissues was positively correlated prognosis. To determine cell proliferation effects inhibition were examined PAI-1-expressing cells. knockdown by small interfering RNA resulted significant suppression growth accompanied G2/M cycle...
To identify a method for breast cancer (BC) surveillance in patients with epithelial ovarian (EOC) germline BRCA1/2 pathogenic variants (gBRCA1/2m) and the incidence of BC after EOC era broad PARP inhibitors use. We retrospectively analyzed data on who had gBRCA1/2m by genetic testing between January 2017 August 2023 our single center. Of 125 EOC, 33 gBRCA1/2m. these, 27 (81.8%) underwent surveillance, 20 ultrasound and/or mammography, seven magnetic resonance imaging (MRI). The median time...
Abstract Ceramides are bioactive lipids that mediate cell death in cancer cells, and ceramide-based therapy is now being tested dose-escalating phase I clinical trials as a treatment. Multiple nanoscale delivery systems for ceramide have been proposed to overcome the inherent toxicities, poor pharmacokinetics, difficult biophysics associated with ceramide. Using nanoliposomes (CNL), we investigate therapeutic efficacy signaling mechanisms of this platform refractory ovarian cancer. Treatment...
Platinum sensitivity is an important prognostic factor in patients with ovarian cancer. Chromodomain-helicase-DNA-binding protein 4 (CHD4) a core member of the nucleosome remodeling and deacetylase complex, which functions as chromatin remodeler. Emerging evidence indicates that CHD4 could be potential therapeutic target for cancer therapy. The purpose this study was to clarify role investigate its focusing on platinum sensitivity. In analysis Cancer Genome Atlas dataset, gene amplification...
The objective of this study was to assess the oncologic outcome surgically-treated patients with early-stage, intermediate-risk cervical cancer according postoperative therapy modality.
Objective:The Japan Society of Gynecologic Oncology (JSGO) published the first practice guideline for endometrial cancer in 2006.The JSGO evaluation committee assessed effect this introduction on clinical and patient outcome using data provided by Obstetrics Gynecology (JSOG) registration system.Methods: Data patients with registered between 2000 2012 were analyzed, epidemiological trends assessed.The influence survival was determined analyzing 2004 2009 competing risk model.Results: In...
Abstract The Japanese government began a human papillomavirus (HPV) vaccination program for girls aged 12‐16 years in 2010 but withdrew its recommendation 2013 because of potential adverse effects, leading to drastically reduced uptake. To evaluate population‐level effects HPV vaccination, women younger than 40 age newly diagnosed with cervical intraepithelial neoplasia grade 1‐3 (CIN1‐3), adenocarcinoma situ (AIS), or invasive cancer (ICC) have been registered at 21 participating institutes...
To obtain baseline data for cervical cancer prevention in Japan, we analyzed human papillomavirus (HPV) from 5045 Japanese women aged less than 40 years and diagnosed with abnormalities at 21 hospitals during 2012-2017. These included intraepithelial neoplasia grade 1 (CIN1, n = 573), CIN2-3 (n 3219), adenocarcinoma situ (AIS, 123), invasive (ICC, 1130). The Roche Linear Array was used HPV genotyping. type-specific relative contributions (RCs) were estimated by adding multiple infections to...
Abstract Ovarian clear cell carcinoma (OCCC) is a rare, chemo-resistant subtype of ovarian cancer. To identify novel therapeutic targets and combination therapies for OCCC, we subjected set patient-derived cancer lines to arrayed high-throughput siRNA drug screening. The results indicated OCCC cells are vulnerable knockdown epigenetic gene such as bromodomain extra-terminal domain (BET) proteins BRD2 BRD3. Subsequent RNA interference assays, well BET inhibitor treatments, validated these...
Epithelial ovarian cancer (EOC) is a fatal gynecologic cancer, and its poor prognosis mainly due to delayed diagnosis. Therefore, biomarker identification prediction are crucial in EOC. Altered cell metabolism characteristic feature of cancers, metabolomics reflects an individual’s current phenotype. In particular, plasma metabolome analyses can be useful for identification. this study, we analyzed 624 metabolites, including uremic toxins (UTx) derived from 80 patients with EOC using...
Platinum resistance is one of the most challenging problems in ovarian cancer treatment. High-throughput functional siRNA screening identified tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE-1) as a gene that confers cells resistant to cisplatin. Conversely enforced over-expression TIE-1 was validated decrease cisplatin sensitivity multiple cell lines up-regulation correlated poor prognosis patients cancer. Mechanistically, up-regulates nucleotide excision repair (NER)...
Ovarian cancer (OC) is an intractable gynecological tumor, and frequent recurrence experienced within a few years even after the complete eradication of tumor tissues by radical resection neo-adjuvant chemotherapies. The conventional marker, CA125, widely used for follow-up OC, but CA125 has long half-life in blood lacks dynamic responses to recurrence. Recent developments liquid biopsy procedures are expected overcome difficulties early diagnosis OC surgery.We applied droplet digital PCR...
Regulation of sphingolipid metabolism plays a role in cellular homeostasis, and dysregulation these pathways is involved cancer progression. Previously, our reports identified ceramide as an anti-metastatic lipid. In the present study, we investigated biochemical alterations ceramide-centered sphingolipids that were associated with metastatic potential. We established metastasis-prone sublines SKOV3 ovarian cells using vivo selection method. These showed decreases levels synthase (CerS) 2...
Endometrial cancer (EMC) is the most common female genital tract malignancy with an increasing prevalence in many countries including Japan, a fact that renders early detection and treatment necessary to protect health fertility. Although are further improve prognosis of women endometrial cancer, biomarkers accurately reflect pathophysiology EMC patients still unclear. Therefore, it clinically critical identify assess diagnosis efficacy facilitate appropriate development new therapies for...
The La-related proteins (LARPs) are a family of RNA binding that control the degradation and stabilization RNAs. As emerging research reveals biology each LARP, it is evident LARPs dysregulated in some types cancer. Upregulation cell motility potentiates metastatic potential ovarian cancer cells; however, roles remain unknown. In present study, we investigated progression using SKOV3 human cells public database integrates microarray-based gene expression data clinical data. To explore...
The impact of histologic subtype on definitive radiotherapy for patients with locally advanced cervical cancer remains unclear. aim this retrospective analysis was to assess clinicopathological findings and clinical outcome by histological type in stage IIB-IVA cancer. Ninety-two [International Federation Gynecology Obstetrics (FIGO) 2008] cancer, who underwent between 2013 2018, were identified as eligible study. information the obtained from medical records our hospital. Seventy-eight...
The aim of the present study was to evaluate oncologic safety and reproductive outcome in patients with stage I epithelial ovarian cancer (EOC) treated fertility-sparing surgery (FSS). Women aged ≤40 years EOC who had undergone FSS between 2000 2010 were retrospectively reviewed. Survival examined using Kaplan-Meier method statistical significance analyzed log-rank test. A total 29 (stage IA, n=14; IC1 n=6; IC3, n=9) from seven participating institutions belonging Tohoku Gynecologic Cancer...
In Japan, the National Immunization Program against human papillomavirus (HPV) targets girls aged 12-16 years, and catch-up vaccination is recommended for young women up to age 26 years. Because HPV infection rates increase soon after sexual debut, we evaluated vaccine effectiveness by at first vaccination. Along with history, genotyping results from 5795 younger than 40 years diagnosed cervical intraepithelial neoplasia grade 2-3 (CIN2-3), adenocarcinoma in situ (AIS), or invasive cancer...
: The usefulness of bevacizumab (BEV) as first-line chemotherapy for advanced ovarian clear cell carcinoma (CCC) was retrospectively evaluated at Tohoku Gynecologic Cancer Unit institutions.