A5002367735- Palliative Care and End-of-Life Issues
- Endometrial and Cervical Cancer Treatments
- Intensive Care Unit Cognitive Disorders
- Ovarian cancer diagnosis and treatment
- Cancer survivorship and care
- Frailty in Older Adults
- Pediatric Pain Management Techniques
- Angiogenesis and VEGF in Cancer
- Pain Management and Opioid Use
- Family and Patient Care in Intensive Care Units
- Healthcare Decision-Making and Restraints
- Sarcoma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Anesthesia and Sedative Agents
- Opioid Use Disorder Treatment
- Cytokine Signaling Pathways and Interactions
Mario Negri Institute for Pharmacological Research
2021-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2024
Azienda Socio Sanitaria Territoriale Lariana
2022
Fondazione Roma
2022
<h3>Introduction/Background</h3> AtTEnd is a phase III randomized international academic trial showing the efficacy of atezolizumab in addition to standard carboplatin and paclitaxel (CP) patients (pts) with advanced/recurrent endometrial cancer. The potential for differences based on ethnicity unknown. <h3>Methodology</h3> In this post hoc analysis, we analyzed combination CP as maintenance vs alone comparing Asian cohort (AC) non-Asian (nAC). <h3>Results</h3> From Oct 2018 Jan 2022, 549...
Pain in cancer patients is a complex clinical problem. systematically assessed and treated during palliative care, but little known about how it addressed before starting care.
In the phase III randomized international multicentric academic AtTEnd trial, addition of atezolizumab (atezo) to standard carboplatin and paclitaxel chemotherapy (CP) demonstrated a statistically significant improvement in progression free survival versus CP alone for patients (pts) with advanced/recurrent endometrial carcinomas (EC) substantial benefit pts mismatch repair deficient (dMMR) carcinoma. This is post-hoc analysis quality-adjusted time without symptoms disease or toxicity...
Delirium occurs in 50–80% of end-of-life patients but is often misdiagnosed. Identification clinical factors potentially associated with delirium onset can lead to a correct early diagnosis. To this aim, we conducted prospective cohort study on from an Italian palliative care unit (PCU) admitted 2018–2019. We evaluated the presence several at patient admission and compared their who developed those did not develop it during follow-up. Among 503 enrolled patients, after median follow-up time...
Introduction: Delirium in end-of-life patients is reported to be between 13% and 42% up 80% the terminal phase. It a serious clinical situation, often cause of death due frequent ineffectiveness treatments. This study aimed assess whether how much precocity diagnosis, hitherto little considered, could affect outcomes prognosis delirium palliative care settings. Methods: Patients consecutively admitted unit (PCU) October 2018 December 2019, cared for both hospice home programs, were analyzed....
Delirium occurs in 50-80% of end-of-life patients but it is often misdiagnosed. Identification clinical factors potentially associated with delirium onset can lead to a correct early diagnosis. To this aim, we conducted an observational prospective study on from Italian Palliative Care Unit (PCU) 2018-2019 and evaluated the presence at patients&rsquo; admission. We then compared their who developed those did not during follow-up. On 503 enrolled patients, 95 (18.9%) delirium. In...
Abstract Purpose Various prognostic indexes have been proposed to improve physicians’ ability predict survival time in advanced cancer patients admitted palliative care (PC), but no optimal score has still identified. The study therefore aims develop and externally validate a new multivariable predictive model this setting. Methods We developed the on 1020 prospectively enrolled home at VIDAS Milan, Italy, between May 2018 February 2020 followed-up June 2020. was then validated among two...