Valentina Arcangeli
A5023897998- Ovarian cancer diagnosis and treatment
- BRCA gene mutations in cancer
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Advanced Breast Cancer Therapies
- Endometrial and Cervical Cancer Treatments
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- PARP inhibition in cancer therapy
- Renal cell carcinoma treatment
- Breast Cancer Treatment Studies
- Pituitary Gland Disorders and Treatments
- DNA Repair Mechanisms
- Lung Cancer Treatments and Mutations
- Glioma Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Lung Cancer Research Studies
- PI3K/AKT/mTOR signaling in cancer
- Intraperitoneal and Appendiceal Malignancies
- Growth Hormone and Insulin-like Growth Factors
- Cancer therapeutics and mechanisms
- Children's Physical and Motor Development
- Genomics and Rare Diseases
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2008-2025
Agostino Gemelli University Polyclinic
2020-2024
Ospedale degli Infermi
2023-2024
Ospedale Infermi di Rimini
2014-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
Ospedale "Santa Maria delle Croci" di Ravenna
2018
Azienda Unità Sanitaria Locale Rimini
2017-2018
Azienda Unità Sanitaria Locale Della Romagna
2018
City Hospital
2004-2016
Università Cattolica del Sacro Cuore
2000-2016
As new genes predisposing to breast (BC) and ovarian cancer (OC) are constantly emerging, the use of panels analyzed by Next-Generation Sequencing (NGS) is increasing in clinical diagnostics. The identification a large number germline mutations allows for deeper knowledge predisposition, although raising many questions about patient management.BC OC patients recruited our counseling service between 2012-2015 were included this study. DNA was extracted from peripheral blood panel 94 involved...
Abstract Background This trial investigated the hypothesis that treatment with trabectedin/PLD (TP) to extend platinum-free interval (TFIp) can improve overall survival (OS) in patients recurrent ovarian cancer (OC). Methods Patients OC (up two previous platinum-based lines), a TFIp of 6–12 months, were randomised receive carboplatin/PLD (CP) or TP followed by platinum therapy at relapse. The primary endpoint was OS (HR: 0.75). Results study enrolled 617 patients. median 8.3 months and 30.3%...
Objectives Neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) may be a valuable treatment option in advanced ovarian cancer when primary cytoreduction is not feasible. However, consensus on the ideal number of NACT cycles still lacking. In present investigation, we aimed to evaluate how influenced patients' outcomes. Methods Data consecutive patients undergoing and IDS were retrospectively reviewed 4 Italian centers, survival outcomes evaluated. Results Overall, 193...
INTRODUCTION: Pancreatic cancer (PC) surveillance of high-risk individuals (HRI) is becoming more common worldwide, aiming at anticipating PC diagnosis a preclinical stage. In 2015, the Italian Registry Families Risk Cancer was created. We aimed to assess prevalence and incidence pancreatic findings, oncological outcomes, harms 7 years after inception, focusing on with least 3-year follow-up or developing events before. METHODS: HRI (subjects family history mutation carriers with/without...
Specific Learning Disorder (SLD) is a neurodevelopmental disorder characterized by difficulties in perceiving and processing verbal non-verbal information. It usually accompanied impaired academic skills leading to school dropout emotional disturbances, resulting significant distress behavioral problems.A cognitive, academic, emotional-behavioral assessment was performed at T0 T1 children adolescents with SLD. Participants received psychotherapy speech therapy treatment from T1.In SLD, the...
Abstract The protein ERp57/GRP58 is a member of the disulfide isomerase family and also glucose‐regulated protein, which, together with other GRPs, induced by variety cellular stress conditions. mainly located in endoplasmic reticulum (ER), but has been found cytoplasm nucleus, where it can bind DNA. In order to identify possible correlation between stress‐response nuclear location ERp57/GRP58, its binding sites on DNA HeLa cells have searched chromatin immunoprecipitation cloning...
Abstract Lynch‐like syndrome (LLS) presents very similar clinicopathological characteristics to Lynch (LS) but the mechanism for cancer predisposition remains unknown. The present study aims investigate causal of LLS by a comprehensive genetic and epigenetic approach. Thirty‐two 34 LS patients with colorectal (CRC) fitting Amsterdam Bethesda criteria were included, along 29 CRC sporadic patients, analyzed presence pathogenic variants in 94 genes associated hereditary tumors. cohorts also...
Abstract Background Current genetic screening for predisposition to breast cancer (BC) is limited BRCA1/2 exons and intron/exon boundaries, information exists about the impact of variants in non-coding regions. The majority alterations identified these regions remain unclassified, but evidence regulatory on risk response treatment emerging. Patients methods This project aimed investigate prevalence germline other BC genes patients with triple-negative (TNBC) selected age at diagnosis and/or...
The main gene involved in gastric cancer (GC) predisposition is CDH1, the pathogenic variants of which are associated with diffuse-type (DGC) and lobular breast (LBC). CDH1 only explains a fraction (10-50%) patients suspected DGC/LBC genetic predisposition. To identify novel susceptibility genes, thus improving management families at risk, we performed multigene panel testing on selected patients. We searched for germline 94 cancer-related genes 96 GC or LBC Italian early-onset and/or family...
E-cadherin is a key player in gastric cancer (GC) and germline alterations of CDH1, its encoding gene, are responsible for Hereditary Diffuse Gastric Cancer (HDGC) syndrome. This study aimed at elucidating the role genetic variants DNA methylation CDH1 promoter enhancers regulation gene expression. For this purpose, we analyzed through Next-Generation Sequencing (NGS) series GC cell lines (NCI-N87, KATO-III, SNU-1, SNU-5, GK2, AKG, KKP) corresponding expression levels. By bisulfite genomic...
Male breast cancer (MBC) is a rare tumor, accounting for less than 1% of all cancers. In MBC, genetic predisposition plays an important role; however, only few studies have investigated in depth the role genes other