A5073399108- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Nausea and vomiting management
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Management of metastatic bone disease
- Cancer-related molecular mechanisms research
- PARP inhibition in cancer therapy
- Ureteral procedures and complications
- Cancer-related Molecular Pathways
- Intraperitoneal and Appendiceal Malignancies
- Pancreatitis Pathology and Treatment
- Inflammatory mediators and NSAID effects
- Neurological disorders and treatments
- Surgical Simulation and Training
- Sympathectomy and Hyperhidrosis Treatments
- Anesthesia and Pain Management
- Case Reports on Hematomas
- Minimally Invasive Surgical Techniques
- Genetic Neurodegenerative Diseases
Fukuoka University
2021-2024
Shizuoka Cancer Center
2014-2024
Shikoku Cancer Center
2017
Fukui-ken Saiseikai Hospital
2010
Taisho Pharmaceutical (Japan)
2003-2006
Sendai City Hospital
2000
Kohnan Hospital
1997
University of Shizuoka
1996
National Institutes of Health
1994
National Cancer Institute
1994
This phase III, multicenter, randomized, open-label study investigated the efficacy and safety of nivolumab versus chemotherapy (gemcitabine [GEM] or pegylated liposomal doxorubicin [PLD]) in patients with platinum-resistant ovarian cancer.
The prognosis of gynecological malignancies has improved with the recent advent molecularly targeted drugs and immune checkpoint inhibitors. However, these are expensive contribute to increasing costs medical care.
This phase 1, open‐label, dose‐escalation study was conducted to determine the safety, tolerability, pharmacokinetics and preliminary efficacy of veliparib with carboplatin weekly paclitaxel in Japanese women newly diagnosed, advanced ovarian cancer. Patients received at 100 or 150 mg b.i.d. on days 1–21 (area under concentration–time curve 6 mg/mL•min) day 1 80 mg/m 2 8 15 every 3 weeks for up 21‐day cycles. Dose escalation followed a + design dose‐limiting toxicities, maximum tolerated...
The Japan Society of Gynecologic and Obstetric Endoscopy Minimally Invasive Therapy (JSGOE) introduced a system for the certification laparoscopic surgeons in 2002 facilities 2014. We examined opinions members regarding necessity training technical robotic surgery skills Japan. Members JSGOE were surveyed with two questionnaires. Overall, 870 519 participants responded to first second questionnaires, respectively. Half respondents indicated that both systems necessary. breakdown by age...
The concept of platinum sensitivity and cross-resistance among agents are widely known in the management recurrent ovarian cancer. aim this study was to evaluate two hypotheses regarding validity non-cross-resistance cisplatin analogue with cervical cancer.In retrospective study, clinical data patients cancer, who had a history receiving based chemotherapy (including concurrent chemoradiotherapy [CCRT] cisplatin) received second-line at time recurrence between April 2004 July 2012 were...
We herein report a 71-year-old woman presented with fever, arthralgia, general malaise and leg muscle stiffness following administration of the COVID-19 mRNA vaccine (Comirnaty, Pfizer-BioNTech). Laboratory findings showed an elevated C-reactive protein level erythrocyte sedimentation rate. In addition, Gallium-67 scintigraphy demonstrated increased uptake in multiple joints. Typing human leukocyte antigen (HLA) revealed presence DRB1*0404/*0803 allele. These met diagnostic criteria for...
Abstract: NC/Nga mice have pathological and behavioral features similar to those seen in human atopic dermatitis. There are two known dermatitis models mice, one being spontaneous‐induced under conventional conditions the other 2,4,6‐trinitrochlorobenzene (TNCB)‐induced allergic contact However, there significant differences time course on development of We studied role scratching behavior (sign itch) spontaneous‐ TNCB‐induced measured counts, transepidermal water loss (TEWL), skin...
Interruption of the inferior vena cava (IVC) is a very rare congenital abnormality. Such patients have many difficulties during ablation procedures. We report case successful paroxysmal atrial fibrillation using superior in patient with interruption IVC.
The aim of this retrospective study was to analyze data for patients with stage IB-IIB uterine cervical cancer who were treated concurrent chemoradiotherapy fluorouracil (5-FU) and cisplatin (CCRT-FP) as postoperative adjuvant therapy re-examine these issues further treatment.Patients high risk recurrence underwent CCRT-FP therapy. A total 73 met criteria included in study. Data related survival, toxicity, treatment feasibility analyzed, the question whether there differences survival...
The purpose of this study was to assess whether peritoneal cytology has prognostic significance in uterine cervical cancer.Peritoneal obtained 228 patients with carcinoma the cervix (International Federation Gynecology and Obstetrics [FIGO] stages IB1-IIB) between October 2002 August 2010. All were negative for intraperitoneal disease at time their radical hysterectomy. pathological features clinical prognosis cases positive examined retrospectively.Peritoneal 9 (3.9%). Of these patients,...
Objective . Olanzapine is proved to be effective for chemotherapy induced nausea and vomiting (CINV). But its efficacy in combination with standard antiemetic therapy unknown. The purpose of this study prove the preventive effect olanzapine prevention CINV caused by highly emetogenic when used therapy. Method Gynecologic cancer patients receiving cisplatin-based who had grade 2 or 3 overall phase (0–120 h after chemotherapy) despite were assigned study. From next cycles which developed...
Human T-cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients may have brain white matter (WM) lesions, but the association of these lesions with disease activity is poorly understood. We retrospectively evaluated WM 22 HAM/TSP (male 4: female 18) including 5 rapid progressors, 16 slow and 1 very progressor. The severity on axial Fluid Attenuated Inversion Recovery images was utilizing Fazekas scale, cerebrospinal fluid biomarkers, proviral load in...
Abstract Objective Pan‐cancer analysis across The Cancer Genome Atlas has revealed the molecular profiles of major types carcinomas. High‐grade serous carcinomas (HGSCs) have been characterized; however, in ovarian cancer, profile carcinoma with minor histopathological changes remains unclear. This study aimed to perform profiling rare malignant tumors, including non‐epithelial tumors (NETs; germ cell and sex cord tumors) clear (CCC), determine how they differ from HGSCs. Methods Sixty‐nine...
Glassy cell carcinoma of the uterine cervix is a rare tumor, and has poor prognosis because its aggressive clinical behavior resistance to radiotherapy chemotherapy. We report case bulky glassy that effectively responded paclitaxel carboplatin in neoadjuvant setting. The patient was 30-year-old woman who became aware vaginal bleeding referred our hospital cancerous tumor cervix. Physical examination showed cervical be approximately 8 cm diameter with no involvement parametrium or vagina....
The interaction of L-selectin and its ligand is widely accepted to mediate leukocyte rolling adhesion on the endothelial surface. Although ubiquitously expressed lymphoid cells, role in execution lymphocyte functions unknown. By flow cytometric analysis using mAb specific for sulfatide, a putative L-selectin, we found that sulfatide was selectively B but not T cells. To elucidate involvement cell activation, present study undertaken investigate effects cell-dependent -independent Ig...
<i>Background:</i> Colonization of <i>Staphylococcus aureus </i>on the skin is one exacerbating factors atopic dermatitis (AD). Reduction bacterial colonization in these lesions was reported to be effective for treatment subjects with AD. Clinical trials have demonstrated efficacy FK-506 (an immunosuppressive macrolide) ointment AD, and many case reports been published regarding its positive effects other inflammatory diseases. Clarithromycin (CAM) a macrolide...