A5062470926- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Cervical Cancer and HPV Research
- Colorectal and Anal Carcinomas
- Endometriosis Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Sarcoma Diagnosis and Treatment
- BRCA gene mutations in cancer
- Gynecological conditions and treatments
- Renal cell carcinoma treatment
- Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Reproductive Biology and Fertility
- Urinary and Genital Oncology Studies
- Genetic factors in colorectal cancer
- PARP inhibition in cancer therapy
- Cancer and Skin Lesions
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Testicular diseases and treatments
- Soft tissue tumor case studies
- Cancer Treatment and Pharmacology
- Cancer Risks and Factors
International University of Health and Welfare
2021-2024
The Cancer Institute Hospital
2013-2022
Japanese Foundation For Cancer Research
2012-2021
Cancer Institute (WIA)
2003
Smoking Research Foundation
2001
Mie University
2001
Mie University Hospital
1999
Yamaguchi University
1992-1994
Kirin (United States)
1994
Shuto General Hospital
1988
Carcinosarcoma (CS) of the uterus or ovary is a rare, aggressive and biphasic neoplasm composed carcinoma sarcoma elements. Previous genomic studies have identified driver genes properties associated with CS. However, there still no molecular subtyping scheme clinical relevance for this disease. Here, we sequence 109 CS samples, focusing on 596 genes. We identify four subtypes that resemble those observed in endometrial carcinoma: POLE-mutated, microsatellite instability, copy number high,...
Intraoperative tumor manipulation and dissemination may possibly compromise survival of women with early-stage cervical cancer who undergo minimally-invasive radical hysterectomy (RH). The objective the study was to examine related RH a "no-look no-touch" technique for clinical stage IB1 cancer.This retrospective compared patients underwent total laparoscopic (TLRH) no-look no-touch (n=80) those an abdominal (ARH; n=83) (≤4 cm) cancer. TLRH incorporates 4 specific measures prevent spillage:...
Introduction BRCA gene mutations are associated with hereditary ovarian cancer. plays a key role in genome integrity, and result an increased risk for Although various guidelines recommend testing patients cancer, data on germline (g B RCA ) mutation frequency cancer Japan scarce. Objective This study aimed to determine g BRCA1/2 Japanese stratified by clinicopathological characteristics, assess patients’ satisfaction pre-test genetic counseling. Methods The CHARLOTTE (CHARacterizing the...
This phase III, multicenter, randomized, open-label study investigated the efficacy and safety of nivolumab versus chemotherapy (gemcitabine [GEM] or pegylated liposomal doxorubicin [PLD]) in patients with platinum-resistant ovarian cancer.
Gastric-type mucinous carcinoma (GAS) is a novel variant of the uterine cervix, characterized by aggressive clinical behavior and absence high-risk human papillomavirus. We conducted this study to evaluate chemosensitivity GAS compared with that usual-type endocervical adenocarcinoma (UEA) in patients who had been enrolled our previous study.Of 52 from phase 2 (SGSG005) neoadjuvant chemotherapy docetaxel carboplatin for stage IB2 IIB nonsquamous cervical cancer, 47 (stage IB2, 12; IIA2, 7;...
This was a nation‐wide retrospective study in Japan examining women who underwent radical hysterectomy for clinical stage IB–IIB cervical cancer with pelvic and/or para‐aortic lymph node metastasis between 2004 and 2008. Time to recurrence or death patterns of disease were compared based upon the adjuvant treatment pattern: whole radiotherapy alone ( n = 253), concurrent chemoradiotherapy (CCRT, 502) chemotherapy 319). Women received had similar (5‐year rates, 36.6% vs . 34.1%,...
The purpose of this study was to examine the utility one-step nucleic acid amplification (OSNA) assay using cytokeratin (CK) 19 (KRT19) messenger RNA (mRNA) for detection sentinel lymph node (SLN) metastases in cervical cancer patients.To determine a cutoff value, KRT19 mRNA assessed by OSNA 239 nodes (LNs) (217 histopathologically negative LNs and 22 positive LNs). A value determined statistical analysis copy numbers obtained assay. Subsequently, performance evaluation (applying above) on...
This was the first large-scale prospective observational Japanese study evaluating safety and efficacy of bevacizumab combined with paclitaxel carboplatin for newly diagnosed advanced ovarian cancer. Patients were prospectively enrolled in primary analysis cohort if they had Stage III or IV epithelial ovarian/fallopian tube/primary peritoneal cancer scheduled to receive plus every 3 weeks Cycles 1–6 2–22. Primary endpoints bevacizumab-specific adverse events ≥ Grade 3. Secondary...
In the surgical treatment for early-stage cervical carcinoma, it is important to identify preoperatively a low-risk group of patients as candidates less radical surgery avoid morbidity associated with hysterectomy. The aim this study was evaluate correlation between tumor diameter measured using magnetic resonance imaging (MRI) and pathological prognostic factors in International Federation Gynecology Obstetrics (FIGO) stage IB1 carcinoma.A total 125 FIGO cancer were included study. Clinical...
Human epididymis protein 4 (HE4) levels and the Risk of Ovarian Malignancy Algorithm (ROMA) have recently been shown to improve sensitivity specificity epithelial ovarian cancer (EOC) diagnosis. We evaluated HE4 ROMA as diagnostic tools type I II EOC in Japanese women. Women who had a pelvic mass on imaging were scheduled undergo surgery enrolled patients. Serum carbohydrate antigen 125 (CA125) tested 319 women (131 benign, 19 borderline, 75 malignant, 94 healthy controls). CA125, HE4, for...
Objective The aim of this study was to determine the current operative management International Federation Gynecology and Obstetrics (FIGO) stage IB2, IIA2, IIB uterine cervical cancer (bulky tumors) in Japan by surveying member institutions Japanese Gynecologic Oncology Group. Methods We conducted a survey assess management, including indications treatment, at all 199 active Results A total 166 (83.4%) responded survey. For patients with squamous cell carcinoma, 35.5% (59/166) performed...
Interim results from the two-cohort, phase 2 KEYNOTE-100 study (NCT02674061) of 376 patients with previously treated advanced recurrent ovarian cancer (ROC) showed that pembrolizumab monotherapy was associated an objective response rate (ORR) 8.0% (95% CI, 5.4-11.2). We present outcomes for Japanese (n = 21) enrolled in KEYNOTE-100. Patients epithelial ROC had received either 1-3 prior chemotherapy lines and platinum-free interval or treatment-free (PFI; TFI) 3-12 months (cohort A) 4-6...
Genetic abnormalities were detected by comparative genomic hybridization (CGH) in 12 ovarian clear cell adenocarcinomas. DNA sequence copy number (CNAs) occurring more than 20% of the cancers included increased numbers 8q11-q13, 8q21-q22, 8q23, 8q24-qter, 17q25-qter, 20q13-qter and 21q22-qter reduced 19p. Increases 8q23 8q24-qter occurred frequently disease-free patients recurrent/non-surviving (p < 0.05). However, increases 17q25-qter Furthermore, together Additionally, there negative...
To analyze the incidence of pelvic lymph node metastasis in endometrial carcinoma with no myometrial invasion.Between 1971 and 1995, 684 women stage I underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, lymph-adenectomy. The metastases 100 cases without invasion was examined.Histologic examination surgical specimens revealed a single each four cases. 83 grade 1, zero 13 2, 3 tumors.Pelvic cancer is not rare, even 1 tumors. Lymphadenectomies may be necessary all patients...
The objective of this retrospective study was to determine the efficacy adjuvant hysterectomy for treatment residual disease in cervical carcinoma treated with radiation therapy. Between 1971 and 1996, 1590 patients uterine cervix (stages I–IIIb) were Three months after completion therapy, status local control investigated, total abdominal performed cases which central existed cervix. Of patients, identified 162 patients. Among these 35 showed an absence distant metastasis or lateral...
Although postoperative adjuvant chemotherapy is generally recommended for early-stage ovarian cancer, it remains unclear whether also effective clear cell carcinoma (CCC).Seventy-three patients with stage I CCC of the ovary who had undergone complete surgical staging formed study population (stage IA, 20 patients; IC, 53 patients). Survival and multivariate analyses were retrospectively performed to determine effectiveness in these patients.Of total (73 patients), 30 received C-positive),...