A5102971813- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Cervical Cancer and HPV Research
- Endometriosis Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Renal cell carcinoma treatment
- Maternal and fetal healthcare
- Pelvic floor disorders treatments
- Cancer-related molecular mechanisms research
- Testicular diseases and treatments
- Gynecological conditions and treatments
- Hepatitis B Virus Studies
- Anorectal Disease Treatments and Outcomes
- Protease and Inhibitor Mechanisms
- Pregnancy and preeclampsia studies
- Pancreatic and Hepatic Oncology Research
- Cardiovascular Issues in Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Cancer Genomics and Diagnostics
- Prenatal Screening and Diagnostics
- Reproductive tract infections research
- Histone Deacetylase Inhibitors Research
- Sarcoma Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
Osaka City University
2015-2024
Osaka Metropolitan University
2023-2024
Center for Clinical Research (United States)
2024
Izumi City General Hospital
2013-2024
Osaka City General Hospital
2024
Tokyo Metropolitan University
2023
Ishikiriseiki Hospital
2021
Creative Commons
2015
Nagoya City University
1994
Chemotherapy-induced neutropenia is a common complication in cancer treatment. In this study, we investigated chemotherapy-induced that was recently detected all patients with gynecologic malignancy. Between January 2009 and December 2011, examined cases of reported our hospital. We analyzed the incidence clinical features febrile During study period, administered over 1614 infusions (29 regimens) to 291 patients. The median age 60 years (range 24-84 years). occurred 147 (50.5%) 378 (23.4%)...
The residual tumor after surgery is the most significant prognostic factor of patients with epithelial ovarian cancer. Near-infrared (NIR) fluorescence-guided actively utilized for localization and complete resection during surgery. However, currently available contrast-enhancing agents display low on-target binding, unfavorable pharmacokinetics, toxicity, thus not ideal clinical use. Here we report ultrabright stable squaraine fluorophores optimal pharmacokinetics by introducing an...
Clear cell adenocarcinomas (CA), unlike serous (SA) of the ovary, are often at stage I, resistant to platinum-based drugs and have a poor prognosis. The causes these differences unclear. In this study, in progression between CA SA were examined terms apoptosis-related tumor invasion-related factors. 16 cases reviewed. Excised tissues classified into primary or metastatic loci, expressions survivin, Bcl-2 matrix metalloproteinase-2 (MMP-2) each locus immunohistochemically assayed. Whether...
Objective: In Japan, the possible adverse events upon HPV vaccination was widely reported in media. MHLW announced suspension of aggressively encouraging 2013, and inoculation rate has sharply declined. The aim present study estimation future cervical cancer risk.Methods: latest data on at each age Sakai City were first investigated. experiencing sexual intercourse 12, 13, 14, 15, 16, 17 throughout lifetime is assumed to be 0%, 1%, 2%, 5%, 15%, 25%, 85% respectively. risk regarded...
Uterine smooth muscle tumors (SMTs) are common pelvic in women, and most of them diagnosed as usual leiomyoma (UL). Exclusion malignant disease is important the management SMTs. However, differentiation SMTs remains difficult. In this study, we aimed to improve preoperative diagnosis We examined 21 ULs, 7 atypical leiomyomas (ALs), 6 leiomyosarcomas (LMSs), all which were by uterine tumor biopsy. Immunohistochemical findings (low-molecular-mass polypeptide 2 (LMP2) Ki-67) clinical features...
To improve our understanding of cervical adenocarcinoma (AD) and evaluate the clinical pathological variables affecting its prognosis, we retrospectively reviewed medical records 455 patients with cancer [International Federation Gynecology Obstetrics stage I/II; 91 cases AD 364 squamous cell carcinoma (SCC)] who underwent surgery at hospital between January, 1995 August, 2012 compared characteristics prognoses SCC cases, including age, stage, histological type, lymph node metastasis,...
In Japan, new HPV immunizations have dropped dramatically after repeated adverse media reports and a June 2013 temporary suspension of the government's recommendation for vaccine. The aim present study was to develop an efficient strategy improve immunization coverage across Japan.We conducted internet survey in Japan mothers 12-16 year-old girls who were unvaccinated as May, 2015. goal gather behavioral information from improving Japanese coverage.Valid answers obtained 2060 mothers. found...
Vaginal melanoma is a rare tumor, accounting for <1% of all melanomas and ~1-5% vaginal malignant tumors. The prognosis extremely poor, as it often resistant to chemotherapy radiotherapy, metastases may develop in the early stages disease. present study investigated 5 patients with treated at Department Gynecology Osaka City University Hospital (Osaka, Japan) between October, 2000 April, 2014. All cases presented abnormal genital bleeding main complaint. Notably, 3 tumors appeared...
Concurrent chemoradiotherapy is the standard treatment for locally advanced uterine cervical cancer. However, effective neoadjuvant chemotherapy (NAC) can reduce tumor size and facilitate hysterectomy NAC could improve prognosis of patients with if ineffective, radiotherapy must be pursued. This causes a delay in initiating core results worse prognosis. Therefore, identification predictive markers whether likely to cancer patient Uncoupling protein 2 (UCP2) broadly expressed cells,...
Abstract Gynecology in the office setting is developing worldwide. Clinical guidelines for gynecology were first published by Japan Society of Obstetrics and Association Obstetricians Gynecologists 2011. These include a total 72 clinical questions covering four areas (Infectious disease, Malignancies benign tumors, Endocrinology infertility, Healthcare women). followed several answers, backgrounds, explanations references common problems encountered gynecology. Each answer with...
In Japan, the trend for cervical cancer at younger ages has been increasing. As a countermeasure, HPV vaccine was introduced as routine vaccination in April 2013. However, Ministry of Health, Labour and Welfare (MHLW) announced "Suspension its active inoculation recommendation vaccine" June 2016, 32 months after that suspension, we conducted survey via Internet compared results with our previous ones 9 23 suspension (in 2014 2015, respectively). We examined 'time-dependent change' 'intention...
ABSTRACT Objectives To investigate time intervals of ductus venosus (DV) flow velocity waveforms (FVW) in correlation to fetal heart rate and gestational age construct reference ranges for the second third trimester. Furthermore, we FVW through tricuspid valve. Methods Flow DV valve were recorded 135 normal singleton fetuses between 17 38 weeks' gestation. Time systolic (S) early diastolic (D) peaks analyzed regarding acceleration (acc‐S S, acc‐D D) deceleration (dec‐S dec‐D D),...
We present a case of cervical varix and low-lying placenta. A cesarean section was performed because the risk bleeding with vaginal delivery; hemostasis achieved using z sutures at points. After delivery, decreased dramatically in size. It is important to recognize clinical features available treatments for varix.
Introduction Uterine leiomyoma is a benign smooth muscle tumor. It does not necessarily require curative treatment, but if conservative management chosen, it important to rule out uterine leiomyosarcoma. When size increase observed, one must consider malignancy, and thus objective cost-effective measurement of important, especially for early detection malignant change. Although MRI imaging thought be the gold standard diagnosis leiomyosarcoma, frequent impractical because incidence economic...