A5103031545- Nanoplatforms for cancer theranostics
- Connective tissue disorders research
- Elasticity and Material Modeling
- Ovarian cancer diagnosis and treatment
- Luminescence and Fluorescent Materials
- Sarcoma Diagnosis and Treatment
- Endometriosis Research and Treatment
- Dermatological and Skeletal Disorders
- Advanced Nanomaterials in Catalysis
- Cellular Mechanics and Interactions
- Cancer Research and Treatments
- 3D Printing in Biomedical Research
- Protease and Inhibitor Mechanisms
- Bone Tissue Engineering Materials
- Gastrointestinal Tumor Research and Treatment
- Geotechnical Engineering and Soil Mechanics
- Polymer composites and self-healing
- TGF-β signaling in diseases
- Pediatric health and respiratory diseases
- Silicon and Solar Cell Technologies
- Advanced Materials and Mechanics
- Semiconductor materials and interfaces
- Geotechnical Engineering and Soil Stabilization
- Cardiovascular Disease and Adiposity
- Intraperitoneal and Appendiceal Malignancies
University of Connecticut
2021-2025
Gordon Center for Medical Imaging
2019-2023
Harvard University
2019-2023
Massachusetts General Hospital
2019-2023
North Dakota State University
2023
University of British Columbia
2019
National Central University
2004-2006
ITRI International
2006
Abstract Near‐infrared (NIR) fluorescence imaging has advanced medical and image‐guided interventions during the past three decades. Despite tremendous advances in devices, surprisingly only a few dyes are currently available clinic. Previous fluorophores, ZW800‐1A ZW800‐1C, significantly improved poor performance of FDA‐approved indocyanine green. However, is not stable serum ZW800‐1C induces severe stacking aqueous media. To solve such dilemmas, ZW800‐PEG was designed by introducing...
Abstract Developments in tissue engineering over the past decade have offered promising future for repair and reconstruction of damaged tissues. To regenerate three dimensional weight‐bearing implants, advances biomaterials manufacturing technologies prompted cell cultivations with natural or artificial scaffolds, which cells are allowed to proliferate, migrate, differentiate vitro. In this article, we develop a mathematical model growth porous scaffold. By treating cell‐scaffold construct...
The residual tumor after surgery is the most significant prognostic factor of patients with epithelial ovarian cancer. Near-infrared (NIR) fluorescence-guided actively utilized for localization and complete resection during surgery. However, currently available contrast-enhancing agents display low on-target binding, unfavorable pharmacokinetics, toxicity, thus not ideal clinical use. Here we report ultrabright stable squaraine fluorophores optimal pharmacokinetics by introducing an...
Bone morphogenetic protein 10 (BMP-10) is crucial for endothelial cell signaling via activin receptor-like kinase 1 (ALK1), a pathway central to vascular homeostasis and angiogenesis. Dysregulated BMP-10 contributes cardiovascular diseases cancer, highlighting the need control ALK1-mediated responses therapeutic development. biosynthesis involves processing by proprotein convertases (PPCs) resulting in non-covalently associated prodomain-growth factor (PD-GF) complex (CPLX), similar other...
Abstract Near‐infrared (NIR) fluorescence imaging has advanced medical and image‐guided interventions during the past three decades. Despite tremendous advances in devices, surprisingly only a few dyes are currently available clinic. Previous fluorophores, ZW800‐1A ZW800‐1C, significantly improved poor performance of FDA‐approved indocyanine green. However, is not stable serum ZW800‐1C induces severe stacking aqueous media. To solve such dilemmas, ZW800‐PEG was designed by introducing...
Abstract The residual tumor after surgery is the most significant prognostic factor of patients with epithelial ovarian cancer. Near‐infrared (NIR) fluorescence‐guided actively utilized for localization and complete resection during surgery. However, currently available contrast‐enhancing agents display low on‐target binding, unfavorable pharmacokinetics, toxicity, thus not ideal clinical use. Here we report ultrabright stable squaraine fluorophores optimal pharmacokinetics by introducing an...
Near-infrared (NIR) cyanine dyes showed enhanced properties for biomedical imaging. A systematic modification within the skeleton has been made through a facile design and synthetic route optimal bioimaging. Herein, we report synthesis of 11 NIR fluorophores an investigation their physicochemical properties, optical characteristics, photostability, in vivo performance. All synthesized absorb emit 610–817 nm various solvents. These also high molar extinction coefficients ranging from 27,000...
Complete resection without damaging the capsule is gold‐standard surgical approach for nonmetastatic gastrointestinal stromal tumors (GIST). However, accurately locating during surgery challenging because GIST covered by normal mucosal tissue, leading to suboptimal surgeries and increased cancer recurrence rates. To enhance care GIST, a cutting‐edge near‐infrared (NIR) fluorescent nanoprobe presented that enables real‐time navigation of specifically targeting CD117, protein frequently...
Successful imaging of atherosclerosis, one the leading global causes death, is crucial for diagnosis and intervention. Near-infrared fluorescence (NIRF) has been widely adopted along with multimodal/hybrid systems plaque detection. We evaluate two macrophage-targeting fluorescent tracers NIRF (TLR4-ZW800-1C Feraheme-Alexa Fluor 750) in an atherosclerotic murine cohort, where left carotid artery (LCA) ligated to cause stenosis, right (RCA) used as a control. Imaging performed on dissected...
The application of spray device to treat respiratory disease has been effective for a long time. Moreover, the clinical studies show that if droplet size is finer, deeper position trachea could be reached. With an eye on enhancing curative effect, this paper proposed novel nebulizer integrating piezoelectric actuator, micro nozzle plate, and cavity pump achieve high-quality atomizing effect. According simulations experiments, it can inferred distribution in research finer more uniform than...
Accurate mapping of gastrointestinal stromal tumors (GIST) during surgery is difficult, which contributes to the suboptimal diagnosis and recurrence cancers. To overcome this limitation, we developed a near-infrared (NIR) fluorescent nanoprobe for real-time navigation GIST using targeted strategy against CD117 ligand stem cell factor (SCF). A zwitterionic NIR fluorophore conjugated SCF showed specific binding xenograft mouse model CD117-positive GIST-T1 with minimal nonspecific tissue...