A5087401844- Uterine Myomas and Treatments
- Sarcoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- SARS-CoV-2 and COVID-19 Research
- Endometrial and Cervical Cancer Treatments
- NF-κB Signaling Pathways
- Ubiquitin and proteasome pathways
- Endometriosis Research and Treatment
- COVID-19 Clinical Research Studies
- Cardiac tumors and thrombi
- Cancer Cells and Metastasis
- Beetle Biology and Toxicology Studies
- Cytokine Signaling Pathways and Interactions
- Cancer, Hypoxia, and Metabolism
- Animal Virus Infections Studies
- Diabetes and associated disorders
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Reproductive System and Pregnancy
- interferon and immune responses
- Immune Cell Function and Interaction
- HIV/AIDS drug development and treatment
- T-cell and Retrovirus Studies
- Immunotherapy and Immune Responses
- Urinary Tract Infections Management
Kyoto Medical Center
2018-2025
Japan Agency for Medical Research and Development
2022-2024
Japan Science and Technology Agency
2012-2023
National Hospital Organization
2022-2023
Shinshu University
2011-2023
Ōtani University
2013-2023
Tohoku University
2013-2021
Baika Women's University
2020-2021
International University of Health and Welfare
2016-2017
Shizuoka Cancer Center
2016-2017
Abstract Histone acetylation/deacetylation controls chromatin activity and subsequent gene transcription. Recent studies demonstrated the activation of histone deacetylases (HDACs) in various human malignancies; however, expression function HDACs ovarian tumors are not fully understood. In this study, we examined immunohistochemical HDAC1, HDAC2 HDAC3 using tissues obtained from 115 cases compared it with that Ki‐67 (a growth marker), p21, E‐cadherin clinicopathological parameters. addition,...
The nonobese diabetic (NOD) mouse is an animal model of human type I diabetes with a strong genetic component that maps to the major histocompatibility complex (MHC) genome. We have identified in NOD lymphocytes specific proteasome defect results from lack LMP2 subunit. pronounced defective production and activation transcription factor NF-kappaB, which plays important role immune inflammatory responses as well preventing apoptosis induced by tumor necrosis alpha. function splenocytes was...
Maximal human immunodeficiency virus type 1 (HIV-1) gene expression requires specific cellular factors in addition to the virus-encoded trans-activator protein Tat and RNA element TAR. We developed a functional assay, based on transcriptional activation vitro, identify these factors. Here, we describe purification molecular cloning of CA150, nuclear that is associated with polymerase II holoenzyme involved Tat-dependent HIV-1 activation. The sequence CA150 contains an extensive glutamine-...
A novel serine kinase, named nuclear factor kappa B (NF B) has been shown to be associated with the NF B.I complex in cytosol of human primary T lymphocytes. It activates DNA binding activity by directly phosphorylating its p65 and p50 subunits. There is no evidence that it phosphorylates I B. Experiments inhibitors antisera showed distinct from other known kinases such as mitogen-activated protein kinase or Mos. an apparent molecular size 43 kDa determined substrate assay. This might have a...
Hypoxia is known to play important roles in the development and progression of tumors. We previously demonstrated that S100A4, a critical molecule for metastasis, was upregulated ovarian cancer cells. Therefore, we examined mechanisms upregulation S100A4 expression carcinoma cells, with particular attention paid effects hypoxia. The levels were found be correlated invasiveness cells vitro vivo, associated hypomethylation CpG sites first intron cell lines tissues. increased under hypoxia...
Although the majority of smooth muscle neoplasms found in uterus are benign, uterine leiomyosarcoma (LMS) is extremely malignant, with high rates recurrence and metastasis. We earlier reported that mice a homozygous deficiency for LMP2, an interferon (IFN)-γ-inducible factor, spontaneously develop LMS. The IFN-γ pathway important control tumor growth invasion has been implicated several cancers. In this study, experiments human mouse tissues revealed defective LMP2 expression LMS was traced...
Several cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection transmitted from human owners to their dogs have recently been reported. The first ever case SARS-CoV-2 transmission a owner domestic cat was confirmed on March 27, 2020. A tiger zoo in New York, USA, also reportedly infected with SARS-CoV-2. It is believed that tigers caretakers, who were previously this virus. On May 25, 2020, the Dutch Minister Agriculture, Nature and Food Quality reported two...
Highly pathogenic avian influenza virus (HPAI/H5N1) has caused widespread infections in dairy cattle and poultry the United States. Sporadic cases of human HPAI/H5N1 have also been confirmed. To prevent establish treatments for infected individuals, researchers at medical institutions States are analyzing biological characteristics strains confirmed country from March to October 2024. In particular, health care staff such investigating infection with virus. Confirmed mainly involved adults...
Zoonotic diseases refer to infectious caused by pathogens that infect or parasitize both humans and other vertebrate animals. In recent years, the novel coronavirus disease (COVID-19) has been known be a zoonotic disease. Academic fields related include veterinary medicine virology. According report Food Agriculture Organization of United Nations (FAO), approximately 70% new human identified since 1940 are animal origin. On hand, twice as many transmitted from animals humans. words, major...
To determine the clinical usefulness of Bosniak's classification cystic renal masses, differentiation which remains difficult despite significant advances in diagnostic imaging.The computed tomography (CT) findings all histopathologically examined masses diagnosed at our institution were analysed retrospectively; 35 patients with treated between 1986 and 1998. Tissues surgically removed pathologically final diagnosis compared preoperative CT category classification.The histopathological...
Adult T-cell leukemia/lymphoma (ATLL), an aggressive neoplasm etiologically associated with human T-lymphotropic virus type-1 (HTLV-1), is resistant to treatment. In this study, we examined the effects of a new inhibitor deacetylase enzymes, LBH589, on ATLL cells. LBH589 effectively induced apoptosis in ATLL-related cell lines and primary cells reduced size tumors inoculated SCID mice. Analyses, including DNA microarray, revealed that neither death receptors nor p53 pathways contributed...
The multisubunit proteasome complex is the principal mediator of nonlysosomal protein degradation. subunit varies minimally between cells with exception LMP2, LMP7, and LMP10 subunits in rodent human cells. LMP2 LMP7 are encoded by lymphocyte antigen region, they optimize proteolytic mediated presentation. also important for function transcription factor nuclear factor-kappaB (NF-kappaB). It required NF-kappaB p50 p52 generation catalyzes degradation phosphorylated IkappaBalpha. These...
Certain mutant strains of SARS-CoV-2 are known to spread widely among humans, including the receptor binding domain (RBD) mutant, Y453F, from farmed minks, and RBD N501Y, a mutation common three major subvariants (B.1.1.7, B.1.351, B.1.1.248) omicron type BQ.1.1 XBB.1.16 subvariants. We investigated characteristics mutants, Y453F using three-dimensional structural analysis. also effect N501Y or mutants on neutralizing antibodies in serum derived individuals children (aged 5-11 years)...
Background.The impact of serum lipid abnormalities on the progression diabetic kidney disease (DKD) remains conflicting. Furthermore, gender differences in association between dyslipidaemia and outcome DKD are largely unknown. We therefore conducted this single-centre observational cohort study to clarify profiles DKD.
Uterine leiomyosarcoma (LMS) is a highly metastatic smooth muscle neoplasm for which calponin h1 suspected to have biological role as tumor‐suppressor. We earlier reported that LMP2‐null mice spontaneously develop uterine LMS through malignant transformation of the myometrium, thus implicating this protein an anti‐tumorigenic candidate well. In present study, we show LMP2 may negatively regulate independently its in proteasome. Moreover, several lines evidence indicate although does not...
Abstract Natural selection “adaptation” in the coronavirus can occur during amplification vivo farmed minks. such viruses is observed by introduction of mutations SARS- CoV-2 that are not growth process humans. Infection with a mutant (Y453F) SARS-CoV-2 from minks known to widely spread among We investigated virological characteristics this using three-dimensional protein structural analysis. Our experimental study suggests virus variants Y453F mutation partially escaped detection four...