A5047929210- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Estrogen and related hormone effects
- Uterine Myomas and Treatments
- Reproductive Biology and Fertility
- Cervical Cancer and HPV Research
- Gut microbiota and health
- Pregnancy and preeclampsia studies
- Balance, Gait, and Falls Prevention
- Sports Performance and Training
- Clostridium difficile and Clostridium perfringens research
- Lower Extremity Biomechanics and Pathologies
- Protein Kinase Regulation and GTPase Signaling
- Reproductive tract infections research
- Muscle activation and electromyography studies
- Neuroendocrine regulation and behavior
- Gynecological conditions and treatments
- Urinary Tract Infections Management
- Ovarian function and disorders
- Sperm and Testicular Function
- PI3K/AKT/mTOR signaling in cancer
- Neonatal Respiratory Health Research
- Maternal and fetal healthcare
- Protein Tyrosine Phosphatases
Kansai Medical University
2016-2025
The University of Tokyo
2024
Kyoto University
2022
University of Electro-Communications
2000-2021
Tottori University
2009
American College of Surgeons
2009
National Institute of Infectious Diseases
2009
Doshisha University
2009
Uganda Episcopal Conference
2007-2009
Osaka Nishi Clinic
2003
Abstract Background Species-level genetic characterization of complex bacterial communities has important clinical applications in both diagnosis and treatment. Amplicon sequencing the 16S ribosomal RNA (rRNA) gene proven to be a powerful strategy for taxonomic classification bacteria. This study aims improve method full-length rRNA analysis using nanopore long-read sequencer MinION™. We compared it conventional short-read mock community human fecal samples. Results modified our existing...
The serine-threonine kinase Akt/PKB is activated downstream of phosphatidylinositol 3-kinase in response to several growth factor stimuli and has been implicated the promotion cell survival. Although both 3,4,5-trisphosphate (PIP3) 3,4-bisphosphate (PI 3,4-P2) have regulation Akt activity vitro, relative roles these two phospholipids vivo are not well understood. Co-ligation B receptor (BCR) inhibitory FcγRIIB1 on cells results recruitment 5′-inositol phosphatase SHIP signaling complex....
Mitogen-activated protein (MAP) kinase family members, including extracellular signal–regulated (ERK), c-Jun NH2-terminal ( JNK), and p38 MAP kinase, have been implicated in coupling the B cell antigen receptor (BCR) to transcriptional responses. However, mechanisms that lead activation of these members poorly elucidated. Here we demonstrate BCR-induced ERK is reduced by loss Grb2 or expression a dominant-negative form Ras, RasN17, whereas this response not affected Shc. The inhibition was...
Interleukin-15 (IL-15) is a novel cytokine that stimulates lymphocyte proliferation and migration via trimeric receptor sharing the β andγ signal-transducing chains with IL-2 receptor. It suggested IL-15 involved in regulating differentiation of uterine natural killer cells. In human endometrium, we have recently reported messenger ribonucleic acid (mRNA) levels significantly increased during secretory phase compared those proliferative phase. this study investigated whether female sex...
In the analysis of human movement, it is significant that appropriate parameters inertia property body segments should be used because they will affect various computed kinetic variables. When analyzing movement elderly people, also desirable to use suitable for elderly. Although there are sets children (Yokoi et al., 1986) and young adults (Ae 1992) Japanese, no report exists on those Japanese The purposes this study were determine mass, location center mass (CM) principal moments about...
Cyclic changes of the human endometrium, such as proliferation, secretion, and decidualization, occur during regular menstrual cycles. Heart– neural crest derivatives–expressed transcript 2 (HAND2) is a key transcription factor in progestin-induced decidualization endometrial stromal cells (ESCs). It has been suggested that HAND2 regulates interleukin 15 (IL15), immune required for activation survival uterine natural killer (uNK) cells. Activated uNK can promote spiral artery remodeling...
Dienogest is a synthetic steroid that has been used as progestogen in contraceptive pills and currently being studied for its possible clinical use the treatment of endometriosis. In this study, we investigated direct effects dienogest differentiation proliferation human endometrial stromal cells (ESC) vitro. After 12 days presence oestradiol (10(-8) mol/l) plus (10(-6) mol/l), cultured ESC underwent morphological produced prolactin, typical marker decidualization. By using Northern blot...
Objective: In Japan, the possible adverse events upon HPV vaccination was widely reported in media. MHLW announced suspension of aggressively encouraging 2013, and inoculation rate has sharply declined. The aim present study estimation future cervical cancer risk.Methods: latest data on at each age Sakai City were first investigated. experiencing sexual intercourse 12, 13, 14, 15, 16, 17 throughout lifetime is assumed to be 0%, 1%, 2%, 5%, 15%, 25%, 85% respectively. risk regarded...
Background/Objectives: Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that plays crucial role in various physiological and pathological processes of the ovary. However, timing HIF-1α expression its specific biological function follicular development human ovary remain unclear. Therefore, this study, we aimed to examine whether downstream gene, N-myc downstream-regulated gene 1 (NDRG1), exhibit stage-specific during process Methods: We used ovarian tissues from eight women...
Despite the advances in assisted reproductive technology, approximately 8–12% of individuals worldwide who are willing to conceive unable do so. Fertility depends on a receptive state endometrium and hormonal adaptations as well immune system. Local systemic immunities greatly influenced by microbiota. The aim present study was compare gut microbiota female patients with that infertility fertile control subjects evaluate effect prebiotic partially hydrolyzed guar gum supplementation...
It has been suggested that the local microbiota in reproductive organs is relevant to women's health and may also affect pregnancy outcomes. Analysis of partial 16S ribosomal RNA (rRNA) gene sequences generated by short-read sequencers used identify vaginal endometrial microbiota, but it requires a long time obtain results, making unsuitable for rapid bacterial identification from small specimen amount clinical context. We developed simple workflow using nanopore sequencer MinION allows...
The endometrium undergoes repeated proliferation and shedding during the menstrual cycle. Significant changes to this environment include fluctuations in partial pressure of oxygen, exposure a high-cytokine associated with intrauterine infection, inflammation. Chronic endometritis is condition wherein mild inflammation persists one causes implantation failure miscarriage early pregnancy. It thought that invasion embryos into requires epithelial-mesenchymal transition (EMT)-associated...