A5015676741- Nuclear physics research studies
- Quantum Chromodynamics and Particle Interactions
- Nuclear Physics and Applications
- Advanced NMR Techniques and Applications
- Astronomical and nuclear sciences
- Endometriosis Research and Treatment
- Atomic and Molecular Physics
- T-cell and B-cell Immunology
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Astro and Planetary Science
- Endometrial and Cervical Cancer Treatments
- Advanced Biosensing Techniques and Applications
- Atomic and Subatomic Physics Research
- Metabolism, Diabetes, and Cancer
- Eosinophilic Disorders and Syndromes
- Cancer, Hypoxia, and Metabolism
- Uterine Myomas and Treatments
- RNA and protein synthesis mechanisms
- Urological Disorders and Treatments
- Pesticide Residue Analysis and Safety
- Monoclonal and Polyclonal Antibodies Research
- Testicular diseases and treatments
- Protein Kinase Regulation and GTPase Signaling
Kansai Medical University
2020-2023
Kokura Memorial Hospital
2022-2023
Tokyo Metropolitan Agriculture and Forestry Research Center
2005-2022
National Hospital Organization
2019-2020
National Institute of Advanced Industrial Science and Technology
2012-2017
Tokyo Metropolitan University
2016
Tokyo Institute of Technology
2006-2015
National Institutes of Natural Sciences
2008-2014
University of Toyama
2012
Osaka Hospital
2010-2011
A substantial proportion of eukaryotic transcripts are considered to be noncoding RNAs because they contain only short open reading frames (sORFs). Recent findings suggest, however, that some sORFs encode small bioactive peptides. Here, we show peptides 11 32 amino acids encoded by the polished rice (pri) sORF gene control epidermal differentiation in Drosophila modifying transcription factor Shavenbaby (Svb). Pri trigger amino-terminal truncation Svb protein, which converts from a repressor...
NZW x BXSB F1 (W/B F1) male mice develop systemic lupus-like disease, and several autoantibodies, circulating immune complexes, lupus nephritis become apparent. The abnormally high incidence of degenerative coronary vascular disease with myocardial infarction thrombocytopenia due to the presence both platelet-associated antibodies antiplatelet in this animal has been reported. We found that W/B produced autoantibodies against cardiolipin (aCL) titer aCL increases age. from were mainly IgG...
Neutron single particle energies have been measured in 23O using the 22O(d,p)23O*-->22O+n process. The of resonant states deduced to be 4.00(2) MeV and 5.30(4) MeV. first excited state can assigned nu d3/2 from a comparison with shell model calculations. 4.0 energy difference between s1/2 gives size N=16 gap which is agreement recent USD05 ("universal" sd 2005) calculation, large enough explain unbound nature oxygen isotopes heavier than A=24. resonance detected at 5.3 out space. Its...
Alpha particles leading to the ground state and first excited of ${\mathrm{K}}^{38}$ in ${\mathrm{Ca}}^{40}(d, \ensuremath{\alpha})$ reaction have been observed excitation energy has determined as 123\ifmmode\pm\else\textpm\fi{}8 kev. The relative intensities groups measured for incident deuteron energies between 3.2 4.1 Mev. Over this range average intensity ground-state group is about 10 times that it concluded latter ${0}^{+}$ $T=1$ analog ${\mathrm{A}}^{38}$ state.Even absence isotopic...
Cyclic changes of the human endometrium, such as proliferation, secretion, and decidualization, occur during regular menstrual cycles. Heart– neural crest derivatives–expressed transcript 2 (HAND2) is a key transcription factor in progestin-induced decidualization endometrial stromal cells (ESCs). It has been suggested that HAND2 regulates interleukin 15 (IL15), immune required for activation survival uterine natural killer (uNK) cells. Activated uNK can promote spiral artery remodeling...
The structure of neutron-rich isotopes 60Cr and 62Cr was studied via proton inelastic scattering in inverse kinematics. deformation lengths (delta) for were extracted as 1.12(16) 1.36(14) fm, respectively, providing evidence enhanced collectivity these nuclei. An excited state at 1180(10) keV identified the first time. We adopted 4;{+} its spin parity, leading to rapid increase Ex(4;{+})/E_{x}(2;{+}) ratio, which indicates development large near N=40. Importance admixture gd-shell component...
The neutron-rich carbon isotopes 19,17C have been investigated via proton inelastic scattering on a liquid hydrogen target at 70 MeV/nucleon. invariant mass method in inverse kinematics was employed to reconstruct the energy spectrum, which fast neutrons and charged fragments were detected coincidence using neutron hodoscope dipole magnet system. A peak has observed with an excitation of 1.46(10) MeV 19C, while three peaks energies 2.20(3), 3.05(3), 6.13(9) 17C. Deduced cross sections are...
Salt inducible kinase (SIK) 1, a member of the AMP-activated (AMPK) family, is activated by AMPK-activator LKB1 which phosphorylates SIK1 at Thr182. The then auto-phosphorylates its Ser186 located +4 position phospho-Ser186 essential for sustained activity SIK1, maintained sequential phosphorylation Ser186-Thr182 glycogen synthase (GSK)-3β. Meanwhile, represses transcription factor cAMP-response element binding protein (CREB) phosphorylating co-activator transducer regulated CREB (TORC)....
Current diagnostic tests such as glycemic indicators have limitations for early detection of impaired glucose tolerance (IGT), which leads to diabetes. Oxidative stress induced by various oxidants in a random and destructive manner is considered play an important role the pathophysiology number human disorders diseases tolerance. We developed improved method measurement vivo lipid peroxidation, where presence 8-iso-prostaglandin F2α (8-iso-PGF2α), hydroxyoctadecadienoic acids (HODEs),...
The vector analyzing power has been measured for the elastic scattering of neutron-rich 6He from polarized protons at 71 MeV/nucleon making use a newly constructed solid proton target operated in low magnetic field and high temperature. Two approaches based on local one-body potentials were applied to investigate spin-orbit interaction between nucleus. An optical model analysis revealed that potential is characterized by shallow long-ranged shape compared with global systematics stable...
Soil samples were obtained from 814 farms in Tokyo 2002. Dieldrin residue was detected 85 soil at concentrations ranging 0.01 ppm to 2.6 ppm. The residual amount 70% of dieldrin-positive 0.1 or less. Concentrations dieldrin cucumbers cultivated exceeded the tolerable level (0.02 ppm) and ranged 0.02 12 330 samples. horizontal distribution fields not uniform range varied quantitative limit (0.01 0.73 vertical also inconsistent. With deeply plowed fields, surface a depth 70 cm, although 30 cm...
Autophosphorylation is an important mechanism by which protein kinases regulate their own biological activities. Salt inducible kinase 1 (SIK1) a regulator in the feedback cascades of cAMP-mediated gene expression, while its domain also features autophosphorylation activity. We provide evidence that Ser186 activation loop site and essential for located at +4 position critical Thr residue Thr182, phosphorylated upstream such as LKB1. The relationship between phosphorylation Thr182 COS-7 cells...
Proton inelastic scattering on the neutron-rich nucleus $^{32}\mathrm{Mg}$ has been studied at 46.5 MeV/nucleon in inverse kinematics. Populated states were identified by measuring de-excitation $\ensuremath{\gamma}$ rays, which five new found $\ensuremath{\gamma}\text{\ensuremath{-}}\ensuremath{\gamma}$ coincidence analyses. By analyzing angular differential cross sections via coupled-channel calculations, their spins and parities constrained amplitudes for each transition extracted. The...
Vector analyzing power for the proton-He6 elastic scattering at 71 MeV/nucleon has been measured first time, with a newly developed polarized proton solid target, which works low magnetic field of 0.09 T. The results are found to be incompatible t-matrix folding model prediction. Comparisons data g-matrix analyses clearly show that vector is sensitive nuclear structure used in reaction analysis. α-core distribution He6 suggested possible key understanding sensitivity.Received 27 May...
The CREB-specific coactivator TORC2 (also known as CRTC2) upregulates gluconeogenic gene expression in the liver. Salt-inducible kinase (SIK) family enzymes inactivate through phosphorylation and localize it cytoplasm. Ser 171 275 were found to be phosphorylated pancreatic β-cells. Calcineurin (Cn) is proposed phosphatase, because its inhibitor cyclosporin A (CsA) stabilizes phospho-Ser retains Because regulation of dephosphorylation at has not been fully clarified, we performed experiments...
The endometrium undergoes repeated proliferation and shedding during the menstrual cycle. Significant changes to this environment include fluctuations in partial pressure of oxygen, exposure a high-cytokine associated with intrauterine infection, inflammation. Chronic endometritis is condition wherein mild inflammation persists one causes implantation failure miscarriage early pregnancy. It thought that invasion embryos into requires epithelial-mesenchymal transition (EMT)-associated...
We isolated a human muscle type of carnitine palmitoyltransferase I (CPTI-M) genomic clone and determined its entire nucleotide sequence. By comparison the sequence with that cDNA, we intron/exon junctions. For detection exon(s) in 5'-region CPTI-M gene, cDNA clones corresponding to transcript by 5'-rapid amplification ends (5'-RACE method). Results showed two alternative exons, 1A 1B, do not encode amino acids gene. The gene encoding was found consist 5'-non-coding 18 coding exons one...
Short-lived nuclides, now extinct in the solar system, are expected to be present interstellar medium (ISM). Grains of ISM origin were recently discovered inner system and at Earth orbit may accrete onto after ablation atmosphere. A favorable matrix for detection such extraterrestrial material is presented by deep-sea sediments with very low sedimentation rates (0.8-3 mm kyr-1). We report here on measurement Pu isotopic abundances a 1 kg dry sediment collected 1992 North Pacific. Our...
We have studied the one-neutron removal reactions of C18 at 81 MeV/nucleon and C19 68 on a liquid hydrogen target. Transverse-momentum distributions core fragments C17 C18, their partial cross sections, are measured using coincidences with γ rays. These compared to theoretical calculations based continuum-discretized coupled-channels (CDCC) method. found that transverse-momentum well described by CDCC calculations, agreement provides evidence for spin-parity assignments Jπ=1/2+ 0.21-MeV...