A5039783762- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Surgical Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal and Anal Carcinomas
- Esophageal and GI Pathology
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Cancer Treatment and Pharmacology
- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Bladder and Urothelial Cancer Treatments
- Colorectal Cancer Screening and Detection
- Glioma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Oral and gingival health research
- Gallbladder and Bile Duct Disorders
- Radiomics and Machine Learning in Medical Imaging
- Vascular Tumors and Angiosarcomas
Japan Clinical Cancer Research Organization
2016-2025
National Cancer Center
2015-2024
Kansai Medical University
2024
Kobe University Hospital
2024
National Cancer Centre Japan
2011-2023
Tokyo Medical and Dental University
2012-2023
RELX Group (Netherlands)
2022
Tokyo National Hospital
2021
Tokyo Medical University Hospital
2020
Nihon University
2018
The aim of the study was to confirm noninferiority mesorectal excision (ME) alone ME with lateral lymph node dissection (LLND) in terms efficacy.Lateral pelvic metastasis is occasionally found clinical stage II or III lower rectal cancer, and LLND standard procedure Japan. alone, however, international surgical for cancer.Eligibility criteria included histologically proven cancer at II/III; main lesion located rectum, margin below peritoneal reflection; no enlargement; Peformance Status 0 1;...
A randomized controlled trial to confirm the non-inferiority of laparoscopic surgery open in terms overall survival was conducted, and short-term surgical outcomes are demonstrated.The efficacy safety outcome for clinical stages II/III colon cancer undergoing Japanese D3 dissection still unclear.Eligibility criteria included cancer; tumor located cecum, ascending, sigmoid, or rectosigmoid colon; T3 T4 without involvement other organs; N0-2; M0. Patients were preoperatively underwent...
Abstract Background Locally advanced gastric cancer with extensive regional and/or para-aortic lymph node (PAN) metastases is typically unresectable and associated poor outcomes. This study investigated the safety efficacy of S-1 plus cisplatin followed by extended surgery PAN dissection for metastasis. Methods Patients bulky metastasis along coeliac artery its branches received two or three 28-day cycles cisplatin, gastrectomy D2 dissection. The primary endpoint was percentage complete...
To clarify the role of splenectomy in total gastrectomy for proximal gastric cancer.Splenectomy is associated with increased operative morbidity and mortality, but its survival benefit unclear. Previous randomized controlled trials were underpowered inconclusive.We conducted a multiinstitutional trial. Proximal adenocarcinoma T2-4/N0-2/M0 not invading greater curvature was eligible. During operation, surgeons confirmed that R0 resection possible negative lavage cytology, patients randomly...
A three-arm Phase III trial was started in November 2012. Preoperative chemotherapy with cisplatin plus 5-fluorouracil is the current standard treatment for locally advanced esophageal cancer Japan, while preoperative chemoradiotherapy Western countries. docetaxel, another promising regimen. The purpose of this study to confirm superiority over and as therapy squamous cell carcinoma esophagus. total 501 patients will be accrued from 41 Japanese institutions within 6.25 years. primary...
To investigate the influence of infectious complications on outcome current standard preoperative chemotherapy followed by surgery for clinical stage II/III esophageal cancer.The impact postoperative survival after transthoracic esophagectomy remains controversial.Data from a randomized controlled trial (JCOG9907) were used. Infectious classified into three groups: pneumonia, anastomotic leakage, and others. Univariate multivariate analyses using Cox proportional hazard model performed.Among...
Background & AimsEsophagectomy is the standard treatment for stage I esophageal squamous cell carcinoma (ESCC). We conducted a single-arm prospective study to confirm efficacy and safety of selective chemoradiotherapy (CRT) based on findings from endoscopic resection (ER).MethodsWe performed patients with T1b (SM1–2) N0M0 thoracic ESCC December 2006 through July 2012; 176 underwent ER. Based ER, received following: no additional pT1a tumors negative margin lymphovascular invasion (group A);...
Purpose Whereas whole-brain radiotherapy (WBRT) has been the standard treatment of brain metastases (BMs), stereotactic radiosurgery (SRS) is increasingly preferred to avoid cognitive dysfunction; however, it not clearly determined whether with SRS as effective that WBRT or plus SRS. We thus assessed noninferiority salvage in patients BMs. Patients and Methods age 20 79 years old performance status scores 0 2-and 3 if caused only by neurologic deficits-and four fewer surgically resected BMs...
It remains controversial whether primary tumor resection (PTR) before chemotherapy improves survival in patients with colorectal cancer (CRC) asymptomatic and synchronous unresectable metastases.This randomized phase III study investigated the superiority of PTR followed by versus alone relation to overall (OS) stage IV CRC three or fewer metastatic diseases confined liver, lungs, distant lymph nodes, peritoneum. Chemotherapy regimens either mFOLFOX6 plus bevacizumab CapeOX were decided...
PURPOSE The standard treatment for postoperative high-risk locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) is chemoradiotherapy with 3-weekly cisplatin (100 mg/m 2 ). However, whether weekly (40 ) yields comparable efficacy in LA-SCCHN unknown. PATIENTS AND METHODS In this multi-institutional open-label phase II/III trial, patients were randomly assigned to receive either or confirm noninferiority cisplatin. primary end point II was proportion completion, that III...
A Phase III study was started in Japan to evaluate the non-inferiority of overall survival laparoscopy-assisted distal gastrectomy with open patients clinical IA (T1N0) or IB [T1N1 T2(MP)N0] gastric cancer. This followed previous II confirm safety (JCOG0703) and began March 2010. total 920 will be accrued from 33 institutions within 5 years. The primary endpoint is survival. secondary endpoints are relapse-free survival, proportion completion, conversion surgery, adverse events, short-term...
Abstract Background The optimal surgical approach for treatment of oesophagogastric junction (OGJ) cancer is controversial. A randomized clinical trial (JCOG9502) comparing transhiatal (TH) and left thoracoabdominal (LTA) approaches was stopped after the first interim analysis owing to limited efficacy LTA resections. Complete 10-year follow-up data are now available. Methods Patients with histologically proven adenocarcinoma OGJ or gastric cardia oesophageal invasion 3 cm less were a TH...