A5090833783- Pharmacogenetics and Drug Metabolism
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Drug Transport and Resistance Mechanisms
- Gastrointestinal Tumor Research and Treatment
- Biochemical and Molecular Research
- Dermatology and Skin Diseases
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Eicosanoids and Hypertension Pharmacology
- Metabolism and Genetic Disorders
- Allergic Rhinitis and Sensitization
- Computational Drug Discovery Methods
- Multiple and Secondary Primary Cancers
- Inflammatory mediators and NSAID effects
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal Cancer Research and Treatment
- Folate and B Vitamins Research
- Analytical Chemistry and Chromatography
- Glutathione Transferases and Polymorphisms
- Receptor Mechanisms and Signaling
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Drug-Induced Hepatotoxicity and Protection
- Pharmaceutical studies and practices
- Biotin and Related Studies
Tohoku University
2016-2025
Tohoku Medical Megabank Organization
2013-2024
Tohoku University Hospital
2003-2024
Center for Innovation
2022-2024
Meijo University
2016-2023
Hiroshima City University
2022-2023
Tohoku Medical and Pharmaceutical University Hospital
2023
Showa Pharmaceutical University
2023
Itami City Hospital
2003-2019
Karolinska Institutet
2008-2011
Gastrectomy with D2 lymphadenectomy is the standard treatment for curable gastric cancer in eastern Asia. Whether addition of para-aortic nodal dissection (PAND) to stage T2, T3, or T4 tumors improves survival controversial. We conducted a randomized, controlled trial at 24 hospitals Japan compare alone plus PAND patients undergoing gastrectomy cancer.Between July 1995 and April 2001, 523 T2b, were randomly assigned during surgery (263 patients) (260 patients). did not permit any adjuvant...
Radical gastrectomy with regional lymphadenectomy is the only curative treatment option for gastric cancer. The extent of lymphadenectomy, however, controversial. two European randomized trials reported an increase in operative morbidity and mortality, but failed to show survival benefit, D2 group. We conducted a controlled trial compare Japanese standard + para-aortic nodal dissection.Only experienced surgeons both procedures from 24 institutions participated study. Patients potentially...
Modern medicine is increasingly focused on personalized medicine, and multi-omics data crucial in understanding biological phenomena disease mechanisms. Each ethnic group has its unique genetic background with specific genomic variations influencing risk drug response. Therefore, from populations are essential for the effective implementation of medicine. Various prospective cohort studies, such as UK Biobank, All Us Lifelines, have been conducted worldwide. The Tohoku Medical Megabank...
Cytochrome P450 2D6 (CYP2D6) is an enzyme of potential importance for the metabolism drugs used clinically, and it exhibits genetic polymorphism with interindividual differences in metabolic activity. To date, 21 <i>CYP2D6</i> allelic variants have been identified Japanese population. The aim this study was to investigate functional characterization CYP2D6 subjects. Wild-type its variants, namely, CYP2D6.2, CYP2D6.10, CYP2D6.14A, CYP2D6.14B, CYP2D6.18, CYP2D6.27, CYP2D6.36, CYP2D6.39,...
Prediction of phenotypic consequences mutations constitutes an important aspect precision medicine. Current computational tools mostly rely on evolutionary conservation and have been calibrated variants associated with disease, which poses conceptual problems for assessment in poorly conserved pharmacogenes. Here, we evaluated the performance 18 current functionality prediction methods leveraging experimental high-quality activity data from 337 genes involved drug metabolism transport found...
Aims The goal of this study was to determine the frequencies important allelic variants CYP2C9 , CYP2C19 CYP2E1 and DPYD in Egyptian population compare them with other ethnic populations. Methods Genotyping (* 2 * 3 ), c2 variant alleles A ‐* 6 ) carried out a total 247 unrelated subjects. An allele‐specific fluorogenic 5′ nuclease chain reaction assay applied for detection variants. Other genes were determined using polymerase (PCR)‐restriction fragment length polymorphism PCR based assays....
The goal of this study was to determine the frequencies important allelic variants in TPMT, NAT2, GST, SULT1A1 and MDR-1 genes Egyptian population compare them with other ethnic populations.Genotyping carried out a total 200 unrelated subjects. TPMT*2 detected using an allele-specific polymerase chain reaction (PCR) assay. TPMT*3C NAT2 (*5,*6 *7) were real-time PCR Detection GSTM1 GSTT1 null alleles performed simultaneously multiplex Finally, PCR-restriction fragment length polymorphism...
PurposeVariability in pharmacokinetics and drug response is shaped by single-nucleotide variants (SNVs) as well copy-number (CNVs) genes with importance for absorption, distribution, metabolism, excretion (ADME). While SNVs have been extensively studied, a systematic assessment of the CNV landscape ADME lacking.MethodsWe integrated data from 2,504 whole genomes 1000 Genomes Project 59,898 exomes Exome Aggregation Consortium to identify CNVs 208 relevant pharmacogenes.ResultsWe describe novel...
Objective Xanthine oxidase (XO) catalyzes the oxidation of endogenous and exogenous purines pyrimidines. In this study, we speculated that individual variations in XO activity are caused by genetic gene. Methods To investigate 96 Japanese participants, denaturing high-performance liquid chromatography was used. assess effects these on enzymatic activity, wild-type 21 types variant – including those database just discovered were transiently expressed COS-7 cells. Results Three nonsynonymous...
Objective Thiopurine S-methyltransferase (TPMT) is an enzyme responsible for the detoxification of widely used thiopurine drugs. TPMT genetically polymorphic and associated with large interindividual variations in drug toxicity therapeutic efficacy. In this study, we performed in-vitro analysis variant alleles, namely, TPMT*2, *3A, *3B, *3C, *5, *6, *7, *8, *9, *10, *11, *12, *13, *14, *16, *17, *18, *19, *20, *21, *22, *23, *24. Methods The wild-type proteins, TPMT.1 23 variants were...