A5020059646- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Inflammatory Bowel Disease
- Anorectal Disease Treatments and Outcomes
- Calcium signaling and nucleotide metabolism
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Cellular transport and secretion
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Screening and Detection
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Nutrition and Health in Aging
- Cancer, Hypoxia, and Metabolism
Osaka University
2014-2025
Osaka International Cancer Institute
2016-2025
Center for Cancer Research
2016
Massachusetts General Hospital
2016
Obayashi (Japan)
2016
Harvard University
2015
Osaka Hospital
2006
Abstract Tyrosine kinase inhibitors are effective treatments for non-small-cell lung cancers (NSCLCs) with epidermal growth factor receptor ( EGFR ) mutations. However, relapse typically occurs after an average of 1 year continuous treatment. A fundamental histological transformation from NSCLC to small-cell cancer (SCLC) is observed in a subset the resistant cancers, but molecular changes associated this remain unknown. Analysis tumour samples and cell lines derived mutant patients revealed...
A new genus, Sphingobacterium, two combinations, Sphingobacterium spiritivorum (Holmes, Owen, and Hollis) multivorum Weaver), species, mizutae Flavobacterium indologenes, are described. The genus is characterized distinguished from the by presence in its strains of high concentrations sphingophospholipids as cellular lipid components. S. designated type species Sphingobacterium. ATCC 33299 (= GIFU 1203) F. indologenes 29893 CDC 3716 = 1347 NCTC 10796 RH 542) species. Emended descriptions presented.
Although cancer is a disease with genetic and epigenetic origins, the possible effects of reprogramming by defined factors remain to be fully understood. We studied induction or inhibition cancer-related genes immature status-related whose alterations have been reported in gastrointestinal cells. Retroviral-mediated introduction induced pluripotent stem (iPS) cell was necessary for inducing expression proteins, including Nanog, Ssea4, Tra-1-60, Tra-1-80 esophageal, stomach, colorectal,...
// Yujiro Nishizawa 1, 2, * , Masamitsu Konno 3, Ayumu Asai 3 Jun Koseki Koichi Kawamoto 2 Norikatsu Miyoshi 1 Hidekazu Takahashi Naohiro Nishida Naotsugu Haraguchi Daisuke Sakai Toshihiro Kudo Taishi Hata Chu Matsuda Tsunekazu Mizushima 4 Taroh Satoh Yuichiro Doki Masaki Mori and Hideshi Ishii Department of Gastroenterological Surgery, Graduate School Medicine, Osaka University, Suita, Osaka, Japan Frontier Science for Cancer Chemotherapy, Disease Data Science, Therapeutics Inflammatory...
Abstract Malnutrition has been considered to be associated with the prognosis of cancer. The Geriatric Nutritional Risk Index (GNRI), based on serum albumin levels, present body weight, and ideal is a simple screening tool predict risk nutrition-related morbidity mortality in elderly patients. We aimed evaluate whether preoperative GNRI was postoperative complications patients colorectal cancer (CRC). retrospectively enrolled 313 CRC aged ≥65 years after curative surgery classified them into...
Sox2 is known as the undifferentiated cell marker. Recent studies have shown that may also be involved in maintenance of cancer stem cells (CSCs) skin and bladder cancers. In this study, we aimed to clarify role colorectal CSCs. expression was measured colon clinical samples by qRT-PCR western blot analysis. To visualize active mRNA production, generated a promoter-dependent DsRed fluorescence emission system. Colon lines tumor tissues generally expressed protein. Knockdown siRNA led...
Abstract Background Tissue-resident memory T (Trm) cells are associated with cytotoxicity not only in viral infection and autoimmune disease pathologies but also many cancers. Tumour-infiltrating CD103 + Trm predominantly comprise CD8 that express cytotoxic activation immune checkpoint molecules called exhausted markers. This study aimed to investigate the role of colorectal cancer (CRC) characterise cancer-specific Trm. Methods Immunochemical staining anti-CD8 anti-CD103 antibodies for...
Given that cancer stem cells (CSC) play a key role in drug resistance and relapse, targeting CSCs remains promising therapy. Here we show RAB5/7, which are involved the endolysosomal pathway, roles maintenance of CSC survival via regulation mitophagic pathway. Inhibition RAB5/7 efficiently eliminated colorectal disrupted foci. In addition, identified mefloquine hydrochloride, an antimalarial drug, as novel inhibitor CSC-targeting drug. Endolysosomal LAMP1/2 mediated parkin-dependent...
It is important to establish cancer stem cell (CSC)-targeted therapies eradicate cancer. As it a CSC marker, we focused on Kruppel-like factor 5 (KLF5) in this study.We searched for candidate microRNAs (miRNAs) that inhibited KLF5 expression by silico analyses and screened them colon lines.We identified one promising miRNA, miR-4711-5p, downregulated direct binding. This miRNA suppressed proliferation, migration invasion ability, as well stemness, including decreased marker expression,...
TRIB3 is a human homologue of Drosophila tribbles. Previous studies have shown that controls the cell growth through ubiquitination-dependent degradation other proteins, whereas its significance in prognosis colorectal cancer (CRC) not yet fully understood. This study comprised 202 patients who underwent surgery for CRC, as well 22 lines derived from gastrointestinal cancer. The correlation gene expression with clinical parameters was assessed. biological evaluated by knockdown experiments...
High-output syndrome (HOS) is a complication of ileostomy, which can affect quality life significantly; however, its exact cause remains unknown. The aim this study was to establish the frequency, as well preoperative and intraoperative factors predictive HOS. subjects were 164 consecutive patients who underwent colorectal cancer surgery with ileostomy construction at our institute between January, 2011 August, 2018. Thirteen postoperative complications reported causes HOS, including...
Innate lymphoid cells (ILC) are responsible for mucosal tissue homeostasis and involved in the progression suppression of several types cancer. However, effects ILCs on colorectal cancer poorly understood. We characterized human normal colon tissue, investigating their role tumor immune microenvironment. Normal mucosa tissues were obtained from patients with cancer, isolated by enzymatic digestion. NKp44+ ILC3s high expression tertiary structure (TLS) formation-related genes, including LTA,...
Aim: The aim of this study was to assess changes in body composition during neoadjuvant chemotherapy (NAC) and investigate whether chemotherapy-related toxicities affect patients with esophageal cancer. Patients Methods: In ninety-four who underwent NAC for cancer, assessed before after NAC. Associations between the incidence change were investigated. Results: Forty-four (46.8%) 50 (53.2%) out 94 defined as having sarcopenia NAC, respectively. There no significant difference any toxicity...
Significance Whether acquired epigenetic changes can escape the genome-wide erasure in primordial germ cells, which are embryonic precursors of all types germline cells and gametes, resulting transgenerational transfer has been under debate. We have shown that an vitro cell culture model mouse effectively recapitulates process erasure, including DNA demethylation at both physiologically methylated abnormally hypermethylated imprinting control regions. also identified examples genomic...
Minimally invasive treatment is getting more and important in an aging society. The purpose of this study was to explore the possibility ICG loaded on super carbonate apatite (sCA) nanoparticles as a novel photodynamic therapy (PDT) against cancers. Using colon cancer cells, uptake anti-tumor effects were examined between treatments sCA-ICG. Reactive oxygen species (ROS) production temperature rise also evaluated underlying mechanism. Atomic force microscopy revealed that size sCA-ICG ranged...