A5005251373- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Head and Neck Surgical Oncology
- Brain Metastases and Treatment
- Immunotherapy and Immune Responses
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
- Neurofibromatosis and Schwannoma Cases
- Pituitary Gland Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Acute Ischemic Stroke Management
- Neuroblastoma Research and Treatments
- CAR-T cell therapy research
- Nanoplatforms for cancer theranostics
- Spinal Dysraphism and Malformations
- Cancer, Hypoxia, and Metabolism
- Boron Compounds in Chemistry
- Radiopharmaceutical Chemistry and Applications
- Epilepsy research and treatment
University of Tsukuba
2016-2025
University of Tsukuba Hospital
2011-2025
Tsukuba University of Technology
2024
National Hospital Organization Mito Medical Center
2023
Yokohama City University Hospital
2023
Mito Saiseikai General Hospital
2023
Yokohama City University
2023
Stony Brook University
2020-2022
Neurological Surgery
2020-2022
Kanazawa University
2022
Abstract Purpose: Human Vα24 natural killer T (NKT) cells bearing an invariant Vα24JαQ antigen receptor, the counterpart of murine Vα14 NKT cells, are activated by a specific ligand, α-galactosylceramide (αGalCer, KRN7000), in CD1d-dependent manner. I.v. administration αGalCer-pulsed dendritic (DC) induces significant activation and expansion lung resulting potent antitumor activities mouse tumor metastatic models. We did phase I dose escalation study with DCs cancer patients. Experimental...
Purpose Whereas whole-brain radiotherapy (WBRT) has been the standard treatment of brain metastases (BMs), stereotactic radiosurgery (SRS) is increasingly preferred to avoid cognitive dysfunction; however, it not clearly determined whether with SRS as effective that WBRT or plus SRS. We thus assessed noninferiority salvage in patients BMs. Patients and Methods age 20 79 years old performance status scores 0 2-and 3 if caused only by neurologic deficits-and four fewer surgically resected BMs...
Abstract Purpose: Human Vα24 natural killer T (Vα24 NKT) cells bearing an invariant Vα24JαQ antigen receptor are activated by a glicolipid ligand α-galactosylceramide (αGalCer; KRN7000) in CD1d-dependent manner. The human NKT with αGalCer and interleukin-2 have been shown to produce large amounts of cytokines, such as IFN-γ, also exerting potent killing activity against various tumor cell lines. We did phase I study autologous therapy. Experimental Design: Patients advanced or recurrent...
Abstract Currently, the direct endonasal approach is widely used in endoscopic surgery (EES) for pituitary neuroendocrine tumor. However, a large posterior septal perforation inevitable. We routinely utilize modified para/transseptal using combination of Killian and contralateral rescue flap incision (PTSA with K-R incision). Especially, on ipsilateral side tumor extension to facilitate lateral expansion anterior sphenoidotomy resection. One hundred eighty-nine patients underwent EES PTSA...
Bradykinin (BK) is produced and acts at the site of injury inflammation. In CNS, migration microglia toward lesion plays an important role pathologically. present study, we investigated effect BK on microglial migration. Increased motility cultured was mimicked by B1 receptor agonists markedly inhibited a antagonist but not B2 antagonist. induced chemotaxis in isolated from wild-type B2-knock-out mice B1-knock-out mice. BK-induced blocked pertussis toxin chelating intracellular Ca2+ or low...
Recent sequencing studies demonstrated the MYD 88 L265P mutation in more than 70% of primary central nervous system lymphomas ( PCNSL ), and clinical significance this has been proposed as diagnostic prognostic markers . In contrast, mutational analyses using cell‐free DNA s have reported a variety systemic lymphomas. To investigate how sensitively can be identified from patients, we carried out droplet digital PCR (dd ) targeted deep TDS 14 consecutive patients whom paired tumor‐derived was...
Glioblastoma (GBM) is difficult to cure with conventional multimodal treatment and has an extremely poor prognosis. Boron neutron capture therapy (BNCT) a new particle for malignant tumors in the brain head neck region. This radiotherapy utilizes nuclear reaction between neutrons nonradioactive isotope, boron-10. In this method, boron compound administered transvenously into body. The property of being selectively taken up only by cells tumors, subsequent irradiation can destroy tumor...
A pilot study was performed to investigate the safety and feasibility of autologous formalin‐fixed tumor vaccines (AFTV) clinical responses these by glioblastoma multiforme (GBM) patients. Twelve primary GBM patients were recruited. Eight had recurrent disease while four been treated for but retained a visible mass. AFTV prepared from and/or paraffin‐embedded tissue obtained upon surgery premixed with original adjuvant materials. The given three five‐site intradermal inoculations at weekly...
Antiangiogenic strategy is promising for malignant glioma. Histone deacetylase inhibitors (HDACIs) are unique anticancer agents that exhibit antiangiogenic effects. The in vitro and vivo effects of HDACIs, valproic acid (VPA), were investigated glioma the brain. In vitro, VPA preferentially inhibited endothelial cell proliferation compared to at optimum concentration a dose-dependent manner. reduced vascular growth factor (VEGF) secretion cells manner under both normoxic hypoxic conditions....
This study explored the superiority of temozolomide (TMZ) + interferonβ (IFNβ) to standard TMZ as treatment for newly diagnosed glioblastoma (GBM) via randomized phase II screening design. Eligibility criteria included histologically proven GBM, with 50% tumor located in supratentorial areas, without involvement optic, olfactory nerves, and pituitary gland multiple lesions dissemination. Patients radiotherapy (RT) arm received RT (2.0 Gy/fr/day, 30 fr) (75 mg/m2, daily) followed by...
Temozolomide (TMZ) may enhance antitumor immunity in patients with glioblastoma multiforme (GBM). In this paper the authors report on a prospective Phase I/IIa clinical trial of fractionated radiotherapy (FRT) concomitant TMZ therapy, followed by treatment autologous formalin-fixed tumor vaccine (AFTV) and maintenance newly diagnosed GBM.Twenty-four (age 16-75 years, Karnofsky Performance Scale score ≥ 60% before initiation FRT) GBM received total dose 60 Gy FRT daily concurrent TMZ. After...
Carmustine (BCNU) implants (Gliadel® Wafer, Eisai Inc., New Jersey, USA) for the treatment of malignant gliomas (MGs) were shown to enhance overall survival in comparison placebo controlled clinical trials United States and Europe. A prospective, multicenter phase I/II study involving Japanese patients with MGs was performed evaluate efficacy, safety, pharmacokinetics BCNU implants. The enrolled 16 newly diagnosed 8 recurrent MGs. After insertion (8 sheets maximum, 61.6 mg BCNU) into removal...
Boron neutron capture therapy (BNCT) is a unique anticancer technology that has demonstrated its efficacy in numerous phase I/II clinical trials with boronophenylalanine (BPA) and sodium borocaptate (BSH) used as 10B delivery agents. However, continuous drug administration at high concentrations needed to maintain sufficient concentration within tumors. To address the issue of accumulation retention tumor tissue, we developed MMT1242, novel boron-containing α-d-mannopyranoside. We evaluated...
Background/Objectives: In clinical trials for glioblastoma, efficacy evaluation often deviates from the standard Response Evaluation Criteria in Solid Tumors (RECIST) due to unique characteristics of brain tumors. This study aimed analyze recent trends endpoint settings Phase II glioblastoma conducted during fiscal years (FY) 2020–2022 and compared them with FY2017–2019. Methods: Using Clarivate’s Cortellis™ Clinical Trial Intelligence database, 116 initiated between April 2020 March 2023...
BACKGROUND Carotid webs are rare nonatherosclerotic disorders in the carotid artery and increasingly recognized as factors of ischemic stroke young population. Asymptomatic can be treated with antithrombotic therapy, whereas symptomatic cases frequently require surgical interventions, including endarterectomy (CEA). However, guidelines for optimal timing these treatments remain unestablished, especially compared to atherosclerotic stenotic lesions, due rarity webs. OBSERVATIONS A 50-year-old...
Objective: Regenerative therapy using stem cells to treat cerebral infarction is currently in the research phase. However, this method costly. It also faces other significant challenges, including optimization of timing, delivery methods, and dosage. Therefore, more practical effective therapies are required. Bioabsorbable artificial dura mater made from nonwoven Polyglycolic Acid (PGA) fabric used clinically infarction. Basic Fibroblast Growth Factor (bFGF) has attracted considerable...
Identifying epileptogenic zones non-invasively is challenging due to signal interference by the scalp and skull, necessitating invasive methods like subdural recordings stereoelectroencephalography. Recent microcatheter advancements suggest that a microcatheter-compatible endovascular EEG (eEEG) device could overcome these barriers. We developed thin, flexible eEEG electrode, EP-01, for use with current microcatheters. The comprising platinum electrode alloy wire coated an electrically...
Background/Objectives: In glioblastoma trials, efficacy evaluation often deviates from the standard Response Evaluation Criteria in Solid Tumors (RECIST), an objective response rate (ORR) method, because of unique nature brain tumors. phase II trials fiscal years (FYs) 2017-2019, primary endpoints (PEs) were overall survival (OS) at 29%, ORR 20%, progression-free (PFS) 17%, and OS 10%. Clinical trial methodologies have likely evolved recent years. This study analyzed trends endpoint settings...
Ectopic pituitary neuroendocrine tumors (Pit-NETs) are rare. The authors present two cases of ectopic Pit-NETs located entirely in the suprasellar space without continuity with normal gland. In case 1, a 53-year-old male presented right blindness and left visual field impairment. Preoperative imaging suggested an Pit-NET apoplexy. Intraoperatively, it was found to originate from pars tuberalis stalk. A portion tumor inside stalk intact, resulting subtotal resection. Postoperatively, patient...