A5063532122- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Cerebrospinal fluid and hydrocephalus
- Neonatal and fetal brain pathology
- Tuberous Sclerosis Complex Research
- Neurological disorders and treatments
- Infectious Encephalopathies and Encephalitis
- Vagus Nerve Stimulation Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Head and Neck Surgical Oncology
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Fetal and Pediatric Neurological Disorders
- Vascular Malformations Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Neurosurgical Procedures and Complications
- Genetics and Neurodevelopmental Disorders
- Pharmacy and Medical Practices
- Bacterial Infections and Vaccines
- Metabolism and Genetic Disorders
- Meningioma and schwannoma management
- Glycogen Storage Diseases and Myoclonus
- COVID-19 and Mental Health
Seirei Hamamatsu General Hospital
2016-2025
Seirei Christopher University
2021-2024
Hospices Civils de Lyon
2022
Hôpital Femme Mère Enfant
2022
Wayne State University
2021
Yokohama City University
2021
Tottori University
2020
Winthrop-University Hospital
2019
Hospital for Sick Children
2008-2013
University of Toronto
2008-2013
Object The authors undertook this study to review their experience with cortical resections in the rolandic region children intractable epilepsy. Methods retrospectively reviewed medical records obtained 22 epilepsy arising from region. All patients underwent preoperative electroencephalography (EEG), MR imaging, prolonged video-EEG recordings, functional magnetoencephalography, and some instances PET/SPECT studies. In 21 invasive subdural grid depth electrode monitoring was performed....
Tuberous sclerosis complex (TSC) is a rare autosomal dominant genetic disorder associated with mutations in TSC1 and TSC2 genes, upregulation of mammalian target rapamycin signaling, subsequent tumor formation various organs. Due to the many manifestations TSC their potential complications, management requires expertise multiple medical disciplines. A multidisciplinary care approach recommended by consensus guidelines. Use teams (MDTs) has been shown be beneficial treating other diseases,...
Identifying epileptogenic zones non-invasively is challenging due to signal interference by the scalp and skull, necessitating invasive methods like subdural recordings stereoelectroencephalography. Recent microcatheter advancements suggest that a microcatheter-compatible endovascular EEG (eEEG) device could overcome these barriers. We developed thin, flexible eEEG electrode, EP-01, for use with current microcatheters. The comprising platinum electrode alloy wire coated an electrically...
For patients with infantile epileptic spasms syndrome (IESS) who have achieved remission of (ES), indicators how well the electroencephalographic (EEG) state should be maintained during follow-up are not available. We hypothesized that time course Burden Amplitudes and Epileptiform Discharges (BASED) score after ES is associated relapse. This study aimed to investigate association between relapse BASED scores at initial subsequent period. collected clinical digital EEG data four hospitals...
BCL11A encodes a zinc finger protein that is highly expressed in hematopoietic tissues and the brain, known to function as transcriptional repressor of fetal hemoglobin (HbF). Recently, de novo variants have been reported individuals with intellectual disability syndrome without epilepsy. In this study, we performed whole-exome sequencing 302 patients epileptic encephalopathies (EEs), identified 2 novel variants, c.577delC (p.His193Metfs*3) c.2351A>C (p.Lys784Thr). Both shared major physical...
Vitamin B6-dependent epilepsies are treatable disorders caused by variants in several genes, such as ALDH7A1,PNPO, and others. Recently, biallelic PLPBP, formerly known PROSC, were identified a novel cause of vitamin epilepsies. Our objective was to further delineate the phenotype PLPBP mutation.We 4 unrelated patients harboring total including 3 variants, cohort 700 with developmental epileptic encephalopathies. Clinical information each case collected.Each patient had different clinical...
Abstract Focal cortical dysplasia is the most common malformation during development, sometimes excised by epilepsy surgery and often caused somatic variants of mTOR pathway genes. In this study, we performed a genetic analysis epileptogenic brain malformed lesions from 64 patients with focal dysplasia, hemimegalencephy, tumors, or hippocampal sclerosis. Targeted sequencing, whole-exome single nucleotide polymorphism microarray detected four germline 35 variants, comprising three copy number...
Introduction: Tuberous sclerosis complex (TSC) is a multisystem neurocutaneous disorder. Angiofibromas (AF), fibrous plaques, and hypopigmented macules are the major skin findings in TSC. Topical sirolimus reduces volume redness of AF other findings. However, efficacy early intervention long-term treatment remains to be clarified. We investigated gel for children with Methods: recruited nine (five boys; four girls) TSC AF. used 0.2% over 6 months. reviewed each patient's medical records...
Dense array EEG (dEEG) evenly covers the whole head surface with over 100 channels contributing to more accurate electrical source imaging due higher spatial and temporal resolution. Several studies have shown clinical utility of dEEG in presurgical evaluation epilepsy. However validation measuring accuracy are still needed. This can be achieved through simultaneously recording both scalp intracranial electrodes (icEEG), which is considered as true measure cortical activity at source. The...
Matsuda, Wakoto MD; Sugimoto, Koichi Sato, Naoaki Watanabe, Takashi MD, PhD; Fujimoto, Ayataka Matsumura, Akira PhD Author Information
Abstract Background Subependymal giant cell astrocytoma (SEGA) is occasionally seen in tuberous sclerosis complex (TSC). Two main options are currently available for treating SEGA: surgical resection or pharmacotherapy using mammalian target of rapamycin inhibitors (mTORi). We hypothesized that opportunities SEGA would have reduced with the advent mTORi. Methods retrospectively reviewed charts patients treated between August 1979 and July 2020, divided into a pre-mTORi era group (Pre-group)...
Purpose. To evaluate the clinical utility of dense array electroencephalography (dEEG) for detecting and localizing interictal spikes in temporal lobe epilepsy. Methods. Simultaneous invasive noninvasive recordings were performed across two different groups. (1) The first group underwent both recording with 128 channels (scalp) dEEG sphenoidal electrode recording. (2) second 256 intracranial EEG (icEEG) involving coverage grids strips over lateral mesial lobe. A to comparison was made...
A relationship between seizures and intracranial pressure (ICP) has been proposed, but not clearly identified. Whether changes in ICP can evoke remains controversial. We report the case of a 23-year-old man who had undergone shunt surgery childhood later presented with focal impaired awareness behavior arrest. Seizures were uncontrolled despite 3 years pharmacotherapy, suddenly stopped after removal. Our supports hypothesis that drug-resistant epilepsy be influenced by ICP. In particular,...