Abstract: Force feedback devices, such as motor-based exoskeletons or wearables based on electrical muscle stimulation (EMS), have the unique potential to accelerate users' own reaction time (RT). However, this speedup has only been explored while device is attached user. In fact, very little known regarding whether faster still occurs after user removes from their bodies–this precisely what we investigated by means of a simple (RT) experiment, in which participants were asked tap soon they...

We propose Parallel Ping-Ping, a system that realizes "Parallel Embodiment", the experience of single user controlling multiple bodies simultaneously. The plays ping-pong by 2 robot arms using Virtual Reality (VR) controller, while looking at tables through Head Mounted Display (HMD). computer constantly calculates ball trajectory and motion for arm to hit balls back automatically color cameras. Based on this calculation, integrates user's maintaining sense agency even though with two...

In trans -translation, transfer-messenger RNA (tmRNA), possessing a dual function as tRNA and an mRNA, relieves stalled translation on the ribosome with help of SmpB. Here, we established in vitro system using Escherichia coli -translation factors to evaluate two steps peptidyl transfer from peptidyl-tRNA alanyl-tmRNA resume codon tmRNA. Using this system, effects several mutations upstream tag-encoding region tmRNA were examined. These affected rather than transfer, one them, A84U/U85G,...

Vitamin B6-dependent epilepsies are treatable disorders caused by variants in several genes, such as ALDH7A1,PNPO, and others. Recently, biallelic PLPBP, formerly known PROSC, were identified a novel cause of vitamin epilepsies. Our objective was to further delineate the phenotype PLPBP mutation.We 4 unrelated patients harboring total including 3 variants, cohort 700 with developmental epileptic encephalopathies. Clinical information each case collected.Each patient had different clinical...

The Sense of Agency (SoA), the subjective feeling controlling one’s actions and theirconsequences, has been explained through two primary theoretical frameworks: thecomparator model retrospective views. While comparator focuses on theconsistency between sensory prediction generated internal models theactual input, theories emphasize detection regularitiesbetween own input self-attribution based thisinformation. However, how types processes contribute to exploration ofcontrol remains unclear....

The Sense of Agency (SoA) refers to the subjective feeling controlling one’s actionsand outcomes. Both predictive process and retrospective are considered tocontribute this subject feeling. focuses on consistency betweenthe sensory prediction actual input by internal model, while theretrospective emphasizes detection regularities between action andsensory input. However, how two types processes contribute exploration ofcontrol remains unclear. In present study, we tackled question examining...

Abstract Background A sleep clinic for adults and children was established in the Tokyo Bay Urayasu Ichikawa Medical Centre, August 2012. Given that few clinics are available Japan specifically children, this provides opportunity to provide data on child patients with problems. Methods Records of who visited at Centre aged ≤20 years first visit were retrospectively examined, along initial final diagnoses. Results Of 2,157 between 2012 March 2017, 181 old. In these patients, most frequent...

Transfer-messenger RNA (tmRNA) plays a dual role as tRNA and an mRNA in trans -translation, during which the ribosome replaces with tmRNA encoding tag-peptide. These processes have been suggested to involve several tmRNA-binding proteins, including SmpB ribosomal protein S1. To investigate molecular mechanism of we developed vitro systems using purified ribosome, elongation factors, from Thermus thermophilus . A stalled complex polyphenylalanyl-tRNA Phe was prepared target tmRNA. peptidyl...

Trans ‐translation, in which a ribosome switches between translation of an mRNA and tmRNA, produces chimera polypeptide N‐terminal truncated C‐terminal tag‐peptide encoded by tmRNA. One the tmRNA binding proteins, ribosomal protein S1, has not been found group Gram‐positive bacteria. In this study, trans ‐translation reaction with from Bacillus subtilis belonging to was examined. When gene lacking termination codon expressed B. , 15‐amino acid derived identified C‐termini products. An...

In this paper, we propose ShadowClones, an interface that supports interactions in which a single user can interact with multiple bodies spaces. Recent teleoperation technologies have allowed controlling objects simultaneously, but at the same time, it also exhibited significant challenge, be attributed to high cognitive load caused by switching and recogning various spaces/perspectives repeatedly instantly. To tackle taking advantage of pre-attentive visual cues for users' simultaneous...

We present an approach for covert visual updates by leveraging change blindness with computationally generated morphed images. To clarify the design parameters intentionally suppressing detection morphing visuals, we investigated in three temporal behaviors: blank, eye-blink, and step-sequential changes. The results showed a robust trend of blank more than 33.3 ms eye blink. Our sequential study revealed that participants did not recognize changes until average 57% toward another face small...

Generative adversarial networks (GANs) generate high-dimensional vector spaces (latent spaces) that can interchangeably represent vectors as images. Advancements have extended their ability to computationally images indistinguishable from real such faces, and more importantly, manipulate using inherit values in the latent space. This interchangeability of has potential calculate not only distance space, but also human perceptual cognitive toward images, is, how humans perceive recognize...

Similar to other countries, in Japan, the demand for primary care pediatricians has increased due surge pediatric allergic diseases, and with change a paradigm shift regarding prevention of disease last 20 years, they have had an need retraining. To offer better support children their caregivers, educational needs bridging gap between knowledge practice must be met. Therefore, we developed program including practical interactive approaches 2012.

We developed an anthropomorphic talking robot WT-5 (Waseda Talker No. 5) having a sensor feedback mechanism and novel vocal cords based on human biological structures. The sensory is more important when we producing obstacle consonant sounds, compared to the auditory mechanism. reproduce this by placing tactile sensors pressure palate of reducing error between voice production. cord model was constructed with similar structure vibrated like those human. In addition, using these mechanisms,...

tmRNA has a dual function as tRNA and an mRNA to relieve the stalled ribosome. During this process, enters ribosomal A-site without codonanticodon interaction, but with protein factor SmpB. Here, we established in vitro trans-translation system, which is able evaluate peptidyl transfer alanyltmRNA translation of resume codon on tmRNA. Using effects mutations or SmpB are assessed by measuring incorporations labeled amino acid into polypeptide. Interaction ribosome was studied directed...

In trans-translation, ribosome switches the template for protein synthesis from an mRNA to tmRNA. The molecular mechanism of trans-translation remains mysterious. order clarify how tmRNA move through ribosome, we developed in vitro systems monitor as well translation, which are composed elongation factors, and SmpB all Thermus thermophilus. these systems, early steps including trans-transfer resume codon decoding could be monitored. Using function ribosomal S1 has been suggested involved was...

Abstract Generative adversarial networks (GANs) generate high-dimensional vector spaces (latent spaces) that can interchangeably represent vectors as images. Advancements have extended their ability to computationally images indistinguishable from real such faces, and more importantly, manipulate using inherit values in the latent space. This interchangeability of has potential calculate not only distance space, but also human perceptual cognitive toward images, i.e., how humans perceive...

We explore a "Parallel Interaction", where user controls several bodies concurrently. To demonstrate this type of interaction we developed Ping-Pong". The plays ping-pong by controlling 2 robot arms with Virtual Reality (VR) controller, and while looking from the viewpoint one Head Mounted Display (HMD). HMD view switches between arms' viewpoints according to ball position direction. keep sense agency over (hindered system latency), calculate balls' paths themselves hit balls back; all...

In this paper, phrase prosody is analyzed based on linguistic modalities of constituent words for communicative speech synthesis. Since Japanese final particles and auxiliaries play crucial roles to indicate speaker's intention attitudes as modality differences, sets showing different degree the judgment were employed. Communicative/reading data compared over 5 kinds epistemic (uncertainty what speaker said) 8 evaluative (what wishes listeners be). These differences quantified in 6-point...

We propose Shadow Clones; a user interface with unattended visual information to accomplish multiple tasks in spaces using fast-gaze-switching. Clones provides not only cursor on the view area is gazing at but also cursors other areas that at. To validate Clones, we designed successive reaching task and compared our approach single-cursor interface, which was displayed currently gaze The results showed shadow clones' condition improved performance while maintaining fast switching. Our...

tmRNA has a dual function both as tRNA and mRNA facilitates trans-translation. We made various mutation in domain of tmRNA. Our studies give progressive suggestions on the structure