A5090790775- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Craniofacial Disorders and Treatments
- Neonatal and fetal brain pathology
- Head and Neck Surgical Oncology
- Epilepsy research and treatment
- Cleft Lip and Palate Research
- Glioma Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Neurological disorders and treatments
- Spinal Fractures and Fixation Techniques
- Facial Trauma and Fracture Management
- Meningioma and schwannoma management
- Neuroscience of respiration and sleep
- Bacterial Infections and Vaccines
- Vascular Malformations Diagnosis and Treatment
- dental development and anomalies
- Voice and Speech Disorders
- Neuroblastoma Research and Treatments
- Nerve Injury and Rehabilitation
- Tumors and Oncological Cases
- Assisted Reproductive Technology and Twin Pregnancy
- Child Abuse and Related Trauma
University of British Columbia
2004-2025
British Columbia Children's Hospital
2019-2025
Vancouver Biotech (Canada)
2024
University of Pittsburgh
2010-2023
Neurological Surgery
2013-2023
University of St. Gallen
2022
University of Pittsburgh Medical Center
2013-2020
Children's Hospital of Pittsburgh
2012-2020
Dartmouth–Hitchcock Medical Center
2016-2019
Rutgers, The State University of New Jersey
2016-2019
OBJECT The rate of CSF shunt failure remains unacceptably high. Hydrocephalus Clinical Research Network (HCRN) conducted a comprehensive prospective observational study hydrocephalus management, the aim which was to isolate specific risk factors for failure. METHODS followed all first-time insertions in children younger than 19 years at 6 HCRN centers. Investigator Committee selected, priori, 21 variables be examined, including clinical, radiographic, and design variables. Shunt defined as...
The Hydrocephalus Clinical Research Network (HCRN), which comprises 7 pediatric neurosurgical centers in North America, provides a unique multicenter assessment of the current outcomes CSF shunting nonselected patients. authors present initial results for this cohort and compare them with from prospective trials performed 1990s.Analysis was restricted to patients newly diagnosed hydrocephalus undergoing first time. Detailed perioperative data 2008 through 2012 all HCRN were prospectively...
The use of endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC) has been advocated as an alternative to CSF shunting in infants hydrocephalus. There are limited reports this procedure the North American population, however. authors provide a retrospective review experience combined ETV + CPC within Hydrocephalus Clinical Research Network (HCRN).All children (< 2 years old) who underwent at one 7 HCRN centers before November 2012 were included. Data collected...
To quantify the extent to which cerebrospinal fluid (CSF) shunt revisions are associated with increased risk of CSF infection, after adjusting for patient factors that may contribute infection risk.We used Hydrocephalus Clinical Research Network registry assemble a large prospective 6-center cohort 1036 children undergoing initial placement between April 2008 and January 2012. The primary outcome interest was first infection. Data all subsequent prior where applicable, were obtained....
OBJECT In a previous report by the same research group (Kestle et al., 2011), compliance with an 11-step protocol was shown to reduce CSF shunt infection at Hydrocephalus Clinical Research Network (HCRN) centers (from 8.7% 5.7%). Antibiotic-impregnated catheters (AICs) were not part of but used off some surgeons. The authors therefore began using new that included AICs in effort rate further. METHODS implemented HCRN on January 1, 2012, for all procedures (excluding external ventricular...
OBJECTIVE Endoscopic third ventriculostomy (ETV) is now established as a viable treatment option for subgroup of children with hydrocephalus. Here, the authors report prospective, multicenter results from Hydrocephalus Clinical Research Network (HCRN) to provide most accurate determination morbidity, complication incidence, and efficacy ETV in determine if intraoperative predictors success add substantially preoperative predictors. METHODS All undergoing first (without choroid plexus...
OBJECTIVE Previous Hydrocephalus Clinical Research Network (HCRN) retrospective studies have shown a 15% difference in rates of conversion to permanent shunts with the use ventriculosubgaleal (VSGSs) versus ventricular reservoirs (VRs) as temporization procedures treatment hydrocephalus due high-grade intraventricular hemorrhage (IVH) prematurity. Further research same study line revealed strong influence center-specific decision-making on shunt outcomes. The primary goal this prospective...
OBJECTIVE This study investigated neurodevelopmental outcomes in preterm neonates with posthemorrhagic hydrocephalus (PHH), focusing on the comparative effectiveness of temporary and permanent CSF diversion strategies. METHODS multicenter prospective observational cohort (2012–2021) involved infants diagnosed PHH who underwent either initial or diversion. Patients were assessed using Bayley Scales Infant Toddler Development, Third Edition (BSID-III), at 15–30 months and, when possible, 36–42...
Frame-based stereotactic brain biopsy has played an important role in the management of patients with suspected neoplastic intracranial lesions over last three decades. We reviewed surgical experience one surgeon to determine nature and frequency complications associated this procedure.Records were for 858 undergoing frame-based procedures from January 1986 May 2006. Data on each case prospectively collected by senior author. Procedures Ommaya reservoir placement, brachytherapy, craniotomy...
Object The authors undertook this study to review their experience with cortical resections in the rolandic region children intractable epilepsy. Methods retrospectively reviewed medical records obtained 22 epilepsy arising from region. All patients underwent preoperative electroencephalography (EEG), MR imaging, prolonged video-EEG recordings, functional magnetoencephalography, and some instances PET/SPECT studies. In 21 invasive subdural grid depth electrode monitoring was performed....
OBJECTIVE High-quality data comparing endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC) to shunt and ETV alone in North America are greatly lacking. To address this, the Hydrocephalus Clinical Research Network (HCRN) conducted a prospective study of ETV+CPC infants. Here, these presented compared prospectively collected from historical cohort infants treated or alone. METHODS From June 2014 September 2015, (corrected age ≤ 24 months) requiring treatment for...
1Department of Neurological Surgery, Saint Louis University, St. Louis, Missouri; 2Division Pediatric Goryeb Children’s Hospital, Morristown, New Jersey; 3Department Neurosurgery, University Tennessee Health Science Center, and 4Le Bonheur Memphis, Tennessee; 5De part ment Massachusetts General Hos pital, Boston, Massachusetts; 6Department Sur gery, Oregon & Portland, Oregon; 7De Hos pital Pittsburgh, Pennsylvania; 8Division Department Washington School Medicine, Mis souri; 9Department...
Nivolumab is an immune checkpoint inhibitor (ICI) currently undergoing Phase III clinical trials for the treatment of glioblastoma. The authors present case a 10-year-old girl with glioblastoma treated nivolumab under compassionate-use guidelines. After first dose patient developed hemiparesis, cerebral edema, and significant midline shift due to severe tumor necrosis. She was managed using intravenous dexamethasone discharged on taper. patient's condition rapidly deteriorated after second...
Endoscopic third ventriculostomy combined with choroid plexus cauterization (ETV+CPC) has been adopted by many pediatric neurosurgeons as an alternative to placing shunts in infants hydrocephalus. However, reported success rates have highly variable, which may be secondary patient selection, operative technique, and/or surgeon training. The objective of this prospective multicenter cohort study was identify independent or surgical training predictors ETV+CPC infants.
Hemispherectomy is an established neurosurgical procedure for catastrophic epilepsy in childhood. However, the technique used to achieve optimum outcome remains be determined.We examined influence of hemidecortication (HD) vs peri-insular hemispherotomy (PIH) on patient outcome.The medical records 41 children undergoing hemispherectomy were reviewed demographics, clinical criteria, and surgical outcomes.HD PIH performed 21 20 children, respectively. The mean age at surgery HD was 54 months...
<h3>Objectives</h3> Visual-field deficits following temporal lobe surgery have been reported in the literature. In this prospective study, authors analyse their experience of visual-field 105 consecutive cases undergoing temporal-lobe performed by a single surgeon, with particular consideration to laterality deficit and its functional implications. <h3>Methods</h3> patients an anterior resection for epilepsy, between March 1998 June 2004, were selected. The patient population had mean age 35...
OBJECTIVE Accurate placement of ventricular catheters may result in prolonged shunt survival, but the best target for hole-bearing segment catheter has not been rigorously defined. The goal study was to define a within ventricle with lowest risk failure. METHODS Five variables (ventricular tip location, environment, relationship choroid plexus, holes ventricle, and crosses midline) were defined, assessed interobserver agreement, evaluated their effect on survival univariate multivariate...
The aim of this study was to determine differences in complications and outcomes between posterior fossa decompression with duraplasty (PFDD) without (PFD) for the treatment pediatric Chiari malformation type I (CM1) syringomyelia (SM).
Object Complications of specific pediatric neurosurgical procedures are well recognized. However, focused surveillance on a unit, for all procedures, may lead to better understanding the most important complications, and allow targeted strategies quality improvement. Methods The authors prospectively recorded morbidity mortality events at large unit over 2-year period. Morbidity was defined as any significant adverse outcome or death (for obstructive shunt failure, within 30 days). Multiple...