A5045076936- Intracranial Aneurysms: Treatment and Complications
- Epilepsy research and treatment
- Vascular Malformations Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Moyamoya disease diagnosis and treatment
- Pharmacological Effects and Toxicity Studies
- Acute Ischemic Stroke Management
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Glioma Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroscience and Neuropharmacology Research
- Stroke Rehabilitation and Recovery
- Cerebral Venous Sinus Thrombosis
- Aortic Disease and Treatment Approaches
- Geology and Paleoclimatology Research
- Meningioma and schwannoma management
- Neurological Complications and Syndromes
- Functional Brain Connectivity Studies
- Venous Thromboembolism Diagnosis and Management
- Genetics and Neurodevelopmental Disorders
- Tuberous Sclerosis Complex Research
Nagasaki Medical Center
2014-2025
University of the Ryukyus
1991-2023
University of the Ryukyus University Hospital
1991-2018
Epilepsy Foundation
2017
Albert Einstein College of Medicine
2011-2013
International Christian University
2012
Yeshiva University
2011
Nagasaki University
2002-2003
Summary Objective This retrospective study was designed to assess the impact of corpus callosotomy ( CC ) in patients with intractable West syndrome WS without lesions on magnetic resonance imaging MRI ). Methods involved 56 who underwent between January 2000 and December 2014. Seizure outcomes changes psychomotor development were analyzed. Results Mean age at onset epilepsy time 5.1 22.6 months, respectively. duration before 17.6 months. Video‐electroencephalography EEG monitoring showed...
Purpose: Infantile spasms are the signature seizures of West syndrome. The conventional treatments for infantile spasms, such as adrenocorticotropic hormone (ACTH) and vigabatrin, not always effective, especially in symptomatic (SIS). We tested efficacy carisbamate, a novel neurotherapeutic drug, to suppress multiple-hit rat model SIS, compared it with phenytoin determine if its effect is via sodium-channel blockade. Methods: Sprague-Dawley rats received right intracerebral infusions...
Abstract Focal cortical dysplasia is the most common malformation during development, sometimes excised by epilepsy surgery and often caused somatic variants of mTOR pathway genes. In this study, we performed a genetic analysis epileptogenic brain malformed lesions from 64 patients with focal dysplasia, hemimegalencephy, tumors, or hippocampal sclerosis. Targeted sequencing, whole-exome single nucleotide polymorphism microarray detected four germline 35 variants, comprising three copy number...
Summary Electroencephalography ( EEG ) is commonly used in epilepsy and neuroscience research to study brain activity. The principles of recording such as signal acquisition, digitization, conditioning share similarities between animal clinical systems. In contrast, preclinical studies demonstrate more variability diversity than the types locations electrodes, methods data analysis, scoring patterns associated behaviors. TASK 3 working group International League Against Epilepsy/American...
Summary: Purpose: By means of the intraoperative electrophysiologic observation, we reevaluated “transfer” theory that a transcallosal volley invoked by cortical spike discharge in one hemisphere directly causes its contralateral counterpart via corpus callosum (CC). Methods: Twenty‐six patients who underwent callosotomy were subjects this study. Intraoperatively, electrocorticograms from both hemispheres simultaneously monitored with callosal compound action potentials (CCAPs) CC. Analysis...
We report a case of brain surface angiocentric glioma in 6‐year‐old Japanese boy with medically intractable partial epilepsy. MRI showed somewhat ill‐defined high‐signal lesions on fluid‐attenuated inversion recovery and T2‐weighted imagings the right occipitoparietal cortex. At surgery, yellowish tumor was localized superficial Histologically, predominantly composed elongated astrocytic cells forming rings around blood vessels. Tumor circumferential to vessels predominanted low cellurarity...
Abstract Objective We analyzed the features of fast oscillations ( FO s) and connectivity in hypsarrhythmia to identify biomarkers for predicting seizure outcomes after total corpus callosotomy TCC ) children with pharmacoresistant infantile spasms IS ). hypothesize that power s slow waves would indicate prognosis . Method retrospectively identified 42 who underwent from 2009 2014 at Nagasaki Medical Center. collected preoperative 200 seconds each child. Children were categorized into three...
Our hospital, located on the mainland, serves as a hub center for nine hospitals remote islands of Nagasaki Prefecture, Japan. There are no stroke specialists these islands. We can transfer emergency patients from to our hospital at any time, using teleradiology system and three types helicopter transport. examined efficacy drip ship (DS) method treating with acute ischemic (AIS) islands, in comparison mainland. From 2010 2017, we reviewed 98 consecutive AIS who received intravenous...
Polyarteritis nodosa (PAN) is a rare, systemic necrotizing vasculitis of small and medium size arteries that leads to aneurysms in various organs. Aneurysms associated with PAN are common visceral arteries, however, intracranial especially childhood. A pediatric patient developed serial hemorrhagic strokes from ruptured superior cerebellar artery aneurysm (subarachnoid hemorrhage) de novo the frontoorbital (intracerebral after 9 months. Patients who present candidates for intervention even...
症例は60 歳女性.無症候性右中大脳動脈狭窄症として他施設で経過観察中,頭痛/意識障害で発症した.CT で右前頭葉脳内血腫を伴うくも膜下出血(SAH)を認め,CTA(computed tomographic angiography)/DSA ではM1 が描出されず,A1 より分岐後M1 欠損部を迂回し網状血管塊を介してM2 へ連続する側副血行がみられた.起始部に破裂瘤を認めコイル塞栓した.網状側副血行路を伴う特発性中大脳動脈閉塞症は,近年発生異常に伴う原始血管系の遺残(twig-like MCA)と考えられている.最近その1 亜型として,A1/A2 からM1 部を迂回し末梢へ至る破格側副血行路内に網状血管が遺残するtype が提示された.本例もこれに相当する構造と思われる.起始部に発生したA1 動脈瘤6 例はすべて5 mm 以下であるが,5 例はSAH で発症している.血行動態的/構造的な脆弱性が示唆されており,本type の瘤は小型でも積極的治療適応に入る可能性がある.
Middle cerebral artery (MCA) has a significantly lower incidence of anatomical variations than other intracranial arteries. We present an extremely rare case unruptured aneurysms with the segmental duplicated MCA (d-MCA) formed fenestrated structure at origin.A 55-year-old female underwent direct surgery for top right internal d-MCA. The d-MCA branches separated and had comparable that main trunk. Moreover, there was anastomosis between branches. diagnosed this as Two aneurysmal domes were...
Abstract Objective This retrospective study was designed to observe differences in ictal movements of epileptic spasm (ES) before and after corpus callosotomy (CC). We hypothesized that asymmetric expression ES is more clarified CC would be a good indicator for the hemisphere. Methods selected 16 patients with intractable West syndrome who were seizure‐free subsequent resection or disconnective surgery unilateral retrospectively reviewed their behavioral recorded at...
To report the long-term efficacy of adjunctive lacosamide therapy in patients with juvenile myoclonic epilepsy whose generalized tonic-clonic seizures were significantly reduced by treatment.A retrospective study was conducted who visited Department Child Neurology, National Hospital Organization Nishiniigata Chuo and Pediatrics, Nagasaki Medical Center. Among had been diagnosed epilepsy, those received as for refractory at least 2 years from January 2017 to December 2022, achieved seizure...