A5081014953- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Moyamoya disease diagnosis and treatment
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Mesenchymal stem cell research
- Aortic Disease and Treatment Approaches
- Meningioma and schwannoma management
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Stroke Rehabilitation and Recovery
- Fetal and Pediatric Neurological Disorders
- Lanthanide and Transition Metal Complexes
- Cerebral Venous Sinus Thrombosis
- Neurological Complications and Syndromes
- Neuroscience and Neural Engineering
- Neurogenesis and neuroplasticity mechanisms
- Renal and Vascular Pathologies
- CNS Lymphoma Diagnosis and Treatment
Nagasaki University
2015-2025
Nagasaki University Hospital
2015-2022
Nagasaki Medical Center
2003-2021
Stanford Medicine
2013-2015
Stanford University
2015
Nagasaki Rousai Hospital
2005-2009
Ischaemic stroke is the leading cause of severe long-term disability yet lacks drug therapies that promote repair phase recovery. This occurs days to months after onset and involves brain remapping plasticity within peri-infarct zone. Elucidating mechanisms this critical for development new therapeutics with a broad treatment window. Inhibiting tonic (extrasynaptic) GABA signalling during was reported enhance functional recovery in mice suggesting plays an important function modulating...
Persistent left superior vena cava (PLSVC) is rare, occurring in approximately 0.3%-0.5% of the population. In endovascular treatment (EVT), internal jugular vein (IJV) approached via innominate from cava; however, occasionally absent patients with PLSVC. Careful consideration required when performing EVT, particularly transvenous embolization (TVE). A 70-year-old female presented a cavernous sinus dural arteriovenous fistula. Left external carotid angiography findings showed that multiple...
Cell transplantation therapy offers great potential to improve impairments after stroke. However, the importance of donor age on therapeutic efficacy is unclear. We investigated regenerative capacity transplanted cells focusing (young vs. old) for ischaemic The quantities human mesenchymal stem cell (hMSC) secreted brain-derived neurotrophic factor in vitro and monocyte chemotactic protein-1 at day 7 vivo were both significantly higher young hMSC compared with old hMSC. Male Sprague-Dawley...
<b>BACKGROUND AND PURPOSE:</b> Identifying the precise hemodynamic features, including fistulous point, is essential for treatments of dural arteriovenous fistulas (DAVFs). This study illustrates efficacy DynaCT digital angiograms obtained from a 3D C-arm CT to directly visualize location points in DAVFs. <b>MATERIALS METHODS:</b> retrospective observed 14 consecutive patients with DAVFs, which included 7 cavernous sinuses, 4 transverse-sigmoid 2 convexity-superior sagittal and 1 tentorial...
Background and Purpose— The ivy sign on fluid-attenuated inversion recovery MRI is a specific finding in moyamoya disease (MMD). This indicates decreased cerebral perfusion, dilated pial vasculature, slow leptomeningeal collateral flow. study aimed to clarify the characteristics of perioperative changes relation hyperperfusion, which frequently occurs MMD unknown pathogenesis. Methods— prospective included patients with who underwent superior temporal artery–middle artery single bypass....
Stem cell transplantation for stroke treatment has been a promising therapy in small and large animal models, many clinical trials are ongoing to establish this strategy setting. However, the mechanism underlying functional recovery after stem not fully established there is still need determine ideal subset of cells such therapy. We herein reviewed recent evidences showing transplantation, focusing on endogenous brain repair. First, angiogenesis/neovascularization promoted by trophic factors...
Endovascular treatment for a spontaneous dural carotid-cavernous fistula (CCF) is an established treatment, but stereotactic radiosurgery might provide less-invasive alternative in selected cases. Four women aged 67 to 79 years (mean 72.0 years) with CCFs presented chemosis or bruit. Angiography revealed arteriovenous fistulas the cavernous portion. Three cases were Barrow type D and one was B converted from D. Stereotactic gamma knife surgery performed marginal dose of 13-15 Gy maximum...
To clarify the safety and efficacy of pre-operative embolization using Onyx liquid embolic agent (Onyx; ev3) compared with N-butyl cyanoacrylate (NBCA; Cordis Neurovascular, Inc.) or coils in cerebral arteriovenous malformation (AVM) surgery.This was a retrospective review prospectively collected clinical database brain AVMs treated at our institute from January 2005 to March 2021. A total 38 consecutive patients who underwent AVM resection after were included. Based on materials, divided...
As endovascular treatment becomes more prevalent, aneurysm recurrence from neck remnants, recanalization, incomplete obliteration and bleeding remain major concerns. In the current analysis, we attempted to identify factors related disease progression clinical outcome in patients treated with coil embolization.This study included 58 who underwent embolization for of intracranial aneurysm. The result was evaluated three-dimensional time-of-flight magnetic resonance angiography (TOF MRA)...
Vestibular schwannomas are the most common tumor at cerebellopontine angle, followed by meningiomas. Differentiation of these tumors is critical because different surgical approaches required for treatment. Recent studies have demonstrated utility amide proton transfer (APT)-chemical exchange saturation (CEST) imaging in evaluating malignant brain tumors. However, APT has not been applied benign Here, we explored potential differentiating between and meningiomas angle. We retrospectively...
Our hospital, located on the mainland, serves as a hub center for nine hospitals remote islands of Nagasaki Prefecture, Japan. There are no stroke specialists these islands. We can transfer emergency patients from to our hospital at any time, using teleradiology system and three types helicopter transport. examined efficacy drip ship (DS) method treating with acute ischemic (AIS) islands, in comparison mainland. From 2010 2017, we reviewed 98 consecutive AIS who received intravenous...
症例は60 歳女性.無症候性右中大脳動脈狭窄症として他施設で経過観察中,頭痛/意識障害で発症した.CT で右前頭葉脳内血腫を伴うくも膜下出血(SAH)を認め,CTA(computed tomographic angiography)/DSA ではM1 が描出されず,A1 より分岐後M1 欠損部を迂回し網状血管塊を介してM2 へ連続する側副血行がみられた.起始部に破裂瘤を認めコイル塞栓した.網状側副血行路を伴う特発性中大脳動脈閉塞症は,近年発生異常に伴う原始血管系の遺残(twig-like MCA)と考えられている.最近その1 亜型として,A1/A2 からM1 部を迂回し末梢へ至る破格側副血行路内に網状血管が遺残するtype が提示された.本例もこれに相当する構造と思われる.起始部に発生したA1 動脈瘤6 例はすべて5 mm 以下であるが,5 例はSAH で発症している.血行動態的/構造的な脆弱性が示唆されており,本type の瘤は小型でも積極的治療適応に入る可能性がある.
Pituitary apoplexy associated with aneurysmal rupture is extremely rare and may be misdiagnosed as primary pituitary adenoma apoplexy. The authors present a case of patient caused by an anterior cerebral artery aneurysm embedded within giant adenoma, they review the relevant literature.A 78-year-old man experienced sudden headache progressive vision loss. Magnetic resonance imaging (MRI) revealed tumor abnormal signal intensity. angiography immediately before surgery showed right A1 segment...
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nerve system caused by John Cunningham virus. On MRI, PML may sometimes appear similar to primary nervous lymphoma (PCNSL) and glioblastoma multiforme (GBM). The purpose this pilot study was evaluate potential amide proton transfer (APT) imaging for differentiating from PCNSL GBM.Patients with (n = 4; two men; mean age 52.3 ± 6.1 years), 7; four women; 74.4 5.8 or GBM 11; 6 65.0 15.2 years) who...
Background and purpose T2*-weighted magnetic resonance angiography (SWAN) detects hemodynamic insufficiency as hypointense areas in medullary or cortical veins. We therefore investigated whether SWAN can help predict ischemic penumbra-like lesions patients with acute stroke (AIS). Materials methods Magnetic imaging (MRI) records—including SWAN, diffusion-weighted (DWI), (MRA)—of consecutive major vessel occlusion within 6 h from AIS onset were analyzed. Acute recanalization was defined an...
We report a rare case of de novo ruptured aneurysm arising from the twig-like networks(TLN)of an anomalous collateral artery associated with aplastic or middle cerebral artery(Ap/T-MCA). A 65-year-old woman decreased level consciousness, who had been diagnosed right Ap/T-MCA and was treated coil embolization for A1 at origin 4 years ago, transferred to our hospital. Head CT revealed intracerebral hematoma extending frontal lobe caudate nucleus intraventricular hemorrhage. Subsequent...