A5101997792- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Protein purification and stability
- Intracranial Aneurysms: Treatment and Complications
- T-cell and B-cell Immunology
- Neuroendocrine regulation and behavior
- Viral Infectious Diseases and Gene Expression in Insects
- Marine and fisheries research
- Vascular Malformations Diagnosis and Treatment
- Facial Nerve Paralysis Treatment and Research
- Autoimmune and Inflammatory Disorders
- Pituitary Gland Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Infant Health and Development
- Virus-based gene therapy research
- Renal function and acid-base balance
- Non-Invasive Vital Sign Monitoring
- Immune Cell Function and Interaction
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Coral and Marine Ecosystems Studies
- Food Industry and Aquatic Biology
- HER2/EGFR in Cancer Research
- Complement system in diseases
- Protein Tyrosine Phosphatases
Kyowa Kirin (Japan)
2006-2024
Kyowa Hakko Kirin (Singapore)
2014
Kyowa Kirin International (United Kingdom)
2014
Kwansei Gakuin University
2010-2013
Japan Science and Technology Agency
2010
Fukuoka Kinen Hospital
2002-2003
Yamagata University
2002
Saitama Medical University
1994
Sapporo Medical University
1988
Iwate Medical University
1987
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism of acid-induced folding proteinsYuji Goto, Nobuaki Takahashi, and Anthony L. FinkCite this: Biochemistry 1990, 29, 14, 3480–3488Publication Date (Print):April 10, 1990Publication History Published online1 May 2002Published inissue 10 April 1990https://pubs.acs.org/doi/10.1021/bi00466a009https://doi.org/10.1021/bi00466a009research-articleACS PublicationsRequest reuse permissionsArticle Views1367Altmetric-Citations481LEARN ABOUT THESE...
Blocking the CD40-CD154 interaction is reported to be effective for transplantation management and autoimmune disease models in rodents nonhuman primates. However, clinical trials with anti-CD154 mAbs were halted because of high incidence thromboembolic complications. Thus, we generated characterized a fully human anti-CD40 mAb ASKP1240, as an alternative mAb. In vitro ASKP1240 concentration-dependently inhibited peripheral blood mononuclear cell proliferation induced by soluble CD154....
Human IgG comprises four subclasses with different biological functions. The IgG3 subclass has a unique character, exhibiting high effector function and Fab arm flexibility. However, it is not used as therapeutic drug owing to an enhanced susceptibility proteolysis. Antibody aggregation control also important for antibody development. To date, there have been few reports of during protein expression the low pH conditions needed purification virus inactivation. This study explored potential...
Endovascular treatment for a spontaneous dural carotid-cavernous fistula (CCF) is an established treatment, but stereotactic radiosurgery might provide less-invasive alternative in selected cases. Four women aged 67 to 79 years (mean 72.0 years) with CCFs presented chemosis or bruit. Angiography revealed arteriovenous fistulas the cavernous portion. Three cases were Barrow type D and one was B converted from D. Stereotactic gamma knife surgery performed marginal dose of 13-15 Gy maximum...
Human immunoglobulin G isotype 4 (IgG4) antibodies are suitable for use in either the antagonist or agonist format because their low effector functions prevent target cytotoxicity unwanted cytokine secretion. However, while manufacturing therapeutic antibodies, they exposed to pH during purification, and IgG4 is more susceptible low-pH-induced aggregation than IgG1. Therefore, we investigated underlying mechanisms of at engineered an with enhanced stability. By swapping constant regions IgG1...
Effective delivery of protein therapeutics into the brain remains challenging because difficulties associated with crossing blood-brain barrier (BBB). To overcome this problem, many researchers have focused on antibodies binding transferrin receptor (TfR), which is expressed in endothelial cells, including those BBB, and involved receptor-mediated transcytosis (RMT). RMT anti-TfR provide a useful means delivering brain, but antibody has short half-life blood its broad expression throughout...
Abstract IgG2 subclass antibodies have unique properties that include low effector function and a rigid hinge region. Although some subclasses been clinically tested approved for therapeutic use, they higher propensity than IgG1 aggregation, which can curtail or abolish their biological activity enhance immunogenicity. In this regard, acid‐induced aggregation of monoclonal during purification virus inactivation must be prevented. the present study, we replaced constant domain with IgG1,...
Although esophageal cancer has a poor prognosis after recurrence, some patients have shown long-term survival despite recurrence. We hypothesized that induction of either antitumor Abs or antitumor-specific CTLs could play role in (5 years longer) with recurrence and/or distant metastases. Therefore, we aimed to obtain specifically bind cells by using serum samples from good prognosis. A phage library was prepared PBMC mRNA the patients, and cell panning carried out an line. Results showed...
The direct surgical attack on carotid-siphon aneurysm is hazardous and difficult as compared with other intracranial aneurysms because of its location adjacent to the skull base, optic nerves chiasm. authors report discuss treatment based our experience 20 such in 18 cases during period from October 1971 September 1980. 1. Many arising C2 carotid-ophthalmic portion internal carotid artery can be treated by neck clipping through pterional approach. It preferable clip a contralateral approach...
Abstract Bispecific antibodies (BsAbs) have emerged as a major class of antibody therapeutics owing to their substantial potential in disease treatment. While several BsAbs been successfully approved recent years, ongoing development efforts continue focus on optimizing various tailored particular antigens and action mechanisms, aiming achieve favorable physicochemical properties. generally encounter challenges due unfavorable characteristics poor manufacturing efficiencies, highlighting the...
抗体は，現在では医薬品創出に欠かせないフォーマットとして確立し，幅広く認知されている．だが，一口に抗体医薬といっても，複数の要素技術が採用されており，複合的な技術の蓄積が今日の繁栄を支えている．開発初期には，マウスで取得した抗体の抗原性が問題となっていた．この課題を，マウスなどの異種の動物由来の抗体を部分的にヒト抗体配列に置き換える，キメラ抗体技術や，ヒト化抗体技術，さらには，ファージディスプレイ法やヒト抗体産生遺伝子改変マウスなどによりヒト抗体を取得する方法を開発することにより克服してきた．一方，ADCC活性などの抗体本来の機能をさらに高めるポテリジェント（Potelligent®）技術や，新規機能を付加したバイスペシフィック抗体技術などを搭載した抗体薬品の臨床試験が進んでおり，徐々に上市され始めている．本レビューでは，現在までの抗体技術開発の経緯と将来の技術開発の展望を解説する．
We investigated the clinical features of 64 cases sudden deafness in patients more than 60 years age. Forty-eight (75%) had profound deafness, 13 moderate and three mild deafness. The audiograms 25 showed a flat pattern, gradually descending curve, total deafness.In cases, unaffected ear also hearing impairment variable severity. Fifty-one these demonstrated physiological threshold shift termed presbycusis ear.Hearing 35 (55%) was cured or improved by medical treatment including steroids....
We recently encountered 5 cases of sarcoidosis accompanied with facial paralysis. The courses paralysis varied, and it presented diverse clinical profiles including bilateral paralysis, latent nervous disorder, unilateral difficult to distinguish from Bell's palsy. No particular tendency was observed among other accompanying symptoms.The presence should be considered in treating patients since occasionally disorder. From the findings our patients, we recommend close evaluation for neuropathy...
眼球病変にガンマナイフ治療を施行する際,target pointに正確に照射するために眼球運動を完全に制御する必要がある.症例は54歳,男性.1992年8月,肺癌に対し中下葉切除および化学療法を施行した.2000年10月,左視力障害が出現し,MRIにて左脈絡膜転移および多発性脳転移を認め当院紹介となった.ガンマナイフ治療に際し,眼球は瞬目麻酔後,点眼麻酔を適宜使用しながら4直筋に制御糸をかけて完全に固定した.辺縁線量15Gyにて照射を行い,20週間後も視力の悪化は認められず,有効な視力を維持することができた.本治療法は,眼球転移病変に対し,その効果,低侵襲性から極めて有効な治療法であると考えられた.
Koshu, Hidehiro; Inamura, Hiroo; Takahashi, Nobuaki; Tada, Yuichiro; Aoyagi, Masaru Author Information