A5061191191- Hormonal Regulation and Hypertension
- Cardiomyopathy and Myosin Studies
- Protein Kinase Regulation and GTPase Signaling
- Pulmonary Hypertension Research and Treatments
- Adrenal and Paraganglionic Tumors
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Angiogenesis and VEGF in Cancer
- Protein Tyrosine Phosphatases
- Heart Failure Treatment and Management
- Renin-Angiotensin System Studies
- Viral Infections and Immunology Research
- Cardiac Fibrosis and Remodeling
- Adrenal Hormones and Disorders
- Nitric Oxide and Endothelin Effects
- Cardiac electrophysiology and arrhythmias
- Cellular Mechanics and Interactions
- Cardiovascular Effects of Exercise
- Renal and Vascular Pathologies
- Cell Adhesion Molecules Research
- Congenital Heart Disease Studies
- Apelin-related biomedical research
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
Mie University
2016-2025
Mie University Hospital
2020-2024
National Cancer Center Hospital East
2024
Kagawa University
2014-2016
Yokkaichi Social Insurance Hospital
2015
Osaka University
2014
Mie Agricultural Research Institute
2013
Kitasato University
2013
University Hospital Regensburg
2013
Nagoya Central Hospital
2013
Two mechanisms are proposed to account for the inhibition of myosin phosphatase (MP) involved in Ca 2+ sensitization vascular muscle, ie, phosphorylation either MYPT1, a target subunit MP or CPI-17, an inhibitory phosphoprotein. In cultured aorta smooth muscle cells (VSMCs), stimulation with angiotensin II activated RhoA, and this was blocked by pretreatment 8-bromo-cGMP. VSMCs stimulated II, endothelin-1, U-46619 significantly increased levels both MYPT1 (at Thr696) CPI-17 Thr38). The...
Although Rho-associated kinase (ROCK) activity has been implicated in cardiovascular diseases, the tissue- and isoform-specific roles of ROCKs vascular response to injury are not known. To address role this process, we generated haploinsufficient Rock1 (Rock1(+/-)) Rock2 (Rock2(+/-)) mice performed carotid artery ligations. Following intervention, found reduced neointima formation Rock1(+/-) compared with that WT or Rock2(+/-) mice. This correlated decreased smooth muscle cell proliferation...
The Rho-associated coiled-coil containing kinases, ROCK1 and ROCK2, are important regulators of cell shape, migration, proliferation through effects on the actin cytoskeleton. However, it is not known whether ROCK2 plays an role in development cardiac hypertrophy. To determine loss could prevent hypertrophy, cardiomyocyte-specific ROCK2-null (c-ROCK2–/–) were generated using conditional ROCK2flox/flox mice α-myosin heavy-chain promoter-driven Cre recombinase transgenic mice. Cardiac...
Objective— Rho/Rho-kinase pathway plays pivotal roles in cardiovascular diseases including arteriosclerosis and hypertension. Recently it has become evident that C-reactive protein (CRP), a powerful marker for events, direct proatherothrombotic effects on vascular cells. However, its molecular mechanism not been fully investigated. We examined the involvement of signaling CRP-induced plasminogen activator inhibitor-1 (PAI-1) expression bovine aortic endothelial cells (BAECs). Methods...
The skin is an immune organ that contains innate and acquired systems thus able to respond exogenous stimuli producing large amount of proinflammatory cytokines including IL-1 family members. role the epidermal not limited initiation local inflammatory responses, but also induction systemic inflammation. However, association persistent release members from severe diseases such as psoriasis, epidermolysis bullosa, atopic dermatitis, blistering desmoglein-1 deficiency syndrome with in organs...
Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy and associated with a number of potential outcomes, including impaired diastolic function, heart failure, sudden cardiac death. Various etiologies have been described for HCM, pressure overload mutations in sarcomeric non-sarcomeric genes. However, the molecular pathogenesis HCM remains incompletely understood. In this study, we performed comparative transcriptome analysis to identify dysregulated genes common...
Although several therapeutic options are available for hepatocellular carcinoma (HCC), the outcome is still very poor. One reason complexity of signal transduction in pathogenesis HCC. The aim this study was to identify new HCC-related genes and investigate functions these progression Whole genomes 15 surgically resected HCC specimens were examined copy number alterations with comparative genomic hybridization. Gene expression compared between normal liver tissues. roles studied using...
Bartonella henselae can cause culture-negative endocarditis, and almost all antibiotics included in empirical therapy regimens for endocarditis are ineffective against this pathogen. We report a case of B which identification the pathogen avoided repeated valve destruction surgery.
The Japanese Hypertrophic Cardiomyopathy Registry Study was designed to provide comprehensive, real-world insights into the clinical characteristics and management of hypertrophic cardiomyopathy (HCM) in Japan. This multicentre, prospective study enrolled consecutive patients with HCM from 24 referral hospitals across Japan starting 2016. baseline 1485 by December 2019 are presented this analysis. median ages at registration diagnosis were 69 60 years, respectively, men accounting for 54%...
Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disorder characterized by progressive fibrofatty replacement of the myocardium. In Japanese population, variants desmoglein-2 (DSG2) gene are a major cause ACM, typically following autosomal recessive inheritance pattern. Myosin-binding protein C (MYBPC3) primarily associated with hypertrophic (HCM). Here, we report severe pediatric case ACM compound heterozygous DSG2 and MYBPC3 variants. A 6-year-old asymptomatic girl was diagnosed...
Background:The aim of this study was to assess the echocardiographic characteristics chronic hemodialysis (HD) patients with end-stage renal disease (ESRD) in a multicenter prospective cohort study.
Phosphorylation of the regulatory light chain myosin (MLC) has roles in cardiac function. In vitro, phosphatase target subunit 2 (MYPT2) is a strongly suspected (MP), but there no in-vivo evidence regarding functions MYPT2 heart.Transgenic mice (Tg) overexpressing were generated using alpha-MHC promoter. Tg hearts showed an increased expression and concomitant increase endogenous catalytic type 1 (PP1cdelta), resulting MP holoenzyme. The level phosphorylation ventricular MLC was reduced....
The transcription factor Sox2 plays a central role in the regulation of neuro-sensory development, and many other developmental processes. To gain an depth understanding gene regulation, we previously investigated Sox2-proximal 50-kb region chicken genome to determine enhancers based on functional assays using embryo electroporation. We identified 11 with specificity for tissues. In this study, extended analysis locus-associated 200-kb 16 additional functions development. These roughly...
Abstract This study aimed to develop a machine-learning algorithm diagnose aldosterone-producing adenoma (APA) for predicting APA probabilities. A retrospective cross-sectional analysis of the Japan Rare/Intractable Adrenal Diseases Study dataset was performed using nationwide PA registry in comprised 41 centers. Patients treated between January 2006 and December 2019 were included. Forty-six features at screening 13 confirmatory test used model development calculate probability. Seven...
Left ventricular hypertrophy (LVH) is often seen in patients with primary aldosteronism (PA), and the prevalence of LVH reportedly higher among PA than essential hypertension. However, correlation between aldosterone levels undefined, how affects remains unclear. We, therefore, retrospectively assessed a large database established by multicenter JPAS (Japan Primary Aldosteronism Study) to reveal factors associated without suspected autonomous cortisol secretion. In 1186 studied, basal plasma...