A5013171534- Zebrafish Biomedical Research Applications
- Topic Modeling
- Web Data Mining and Analysis
- Peroxisome Proliferator-Activated Receptors
- Cancer and Skin Lesions
- Metastasis and carcinoma case studies
- Sentiment Analysis and Opinion Mining
- Natural Language Processing Techniques
- Evacuation and Crowd Dynamics
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- MicroRNA in disease regulation
- Transportation Planning and Optimization
- Digital Games and Media
- Esophageal and GI Pathology
- Urban Transport and Accessibility
- Persona Design and Applications
- Retinoids in leukemia and cellular processes
- Nonmelanoma Skin Cancer Studies
- Wikis in Education and Collaboration
- Cerebrovascular and Carotid Artery Diseases
- Consumer Market Behavior and Pricing
- Comics and Graphic Narratives
- Breast Lesions and Carcinomas
CyberAgent (Japan)
2022-2024
Shibaura Institute of Technology
2022-2024
Kyushu Hospital
2014-2022
Tokyo Institute of Technology
2022
Tokyo Medical Center
2021
National Hospital Organization
2021
Mie University
2014-2017
Japan Community Healthcare Organization
2015
Adult Congenital Heart Association
2015
Osaka City University
2015
Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy and associated with a number of potential outcomes, including impaired diastolic function, heart failure, sudden cardiac death. Various etiologies have been described for HCM, pressure overload mutations in sarcomeric non-sarcomeric genes. However, the molecular pathogenesis HCM remains incompletely understood. In this study, we performed comparative transcriptome analysis to identify dysregulated genes common...
Laparoscopic gastrectomy (LG) is increasingly used to treat gastric cancer. Simultaneously, internal hernia (IH) has been reported after LG with Roux-en-Y reconstruction (RY). The aim of this study was investigate IH RY for This included 15 patients from a database 355 consecutive who underwent cancers. We retrospectively analyzed incidence and clinical characteristics by operative procedures. total 4.2%. at Petersen's defect tended decrease modifications the methods, but not significantly...
Pulmonary arterial hypertension (PAH) is a heterogeneous disorder associated with progressive increase in pulmonary artery resistance and pressure. Although various therapies have been developed, the 5-year survival rate of PAH patients remains low. There thus an important need to identify novel genes that are commonly dysregulated etiologies could be used as biomarkers and/or therapeutic targets. In this study, we performed comparative transcriptome analysis five mammalian datasets...
Sleep-wake states are impaired in various neurological disorders. Impairment of sleep-wake can be an early condition that exacerbates these Therefore, treating dysfunction may prevent or slow the development diseases. Although many gene products likely to involved disturbance, hypnotics and psychostimulants clinically used limited terms their mode action not without side effects. there is a growing demand for developing new with high efficacy few Towards this end, animal models indispensable...
Intestinal helminths cause iron-deficiency anemia in pregnant women, associated with premature delivery, low birth weight, maternal ill health, and death. Although benzimidazole compounds such as mebendazole (MBZ) are highly efficacious against helminths, there limited data on its use during pregnancy. In this study, we performed vivo imaging of the retinas zebrafish larvae exposed to MBZ, found that exposure MBZ 2 3 days post-fertilization caused malformation retinal layers. To identify...
An idea key to human-centric city planning is the reclamation of urban spaces from vehicles and their redesign for human activities. Aligned with this concept, study presents a framework network design. The developed based on multi-objective optimization model that designs pedestrian zones within center considering conflicting policy objectives. Design performance evaluated through interaction between design behavior travelers. A vehicle–pedestrian multimodal equilibrium assignment...
Oligodendrocytes are major myelin-producing cells and play essential roles in the function of a healthy nervous system. However, they also one most vulnerable neural cell types central system (CNS), myelin abnormalities CNS found wide variety neurological disorders, including multiple sclerosis, adrenoleukodystrophy, schizophrenia. There is an urgent need to identify small molecular weight compounds that can stimulate myelination. In this study, we performed comparative transcriptome...
Age-related macular degeneration (AMD) is the most common cause of vision loss in elderly individuals throughout developed world. Inhibitors vascular endothelial growth factor have been successfully used to treat choroidal neovascularization late-stage AMD. The pathogenesis early-stage AMD, however, remains largely unknown, impairing efforts develop effective therapies that prevent progression To address this, we performed comparative transcriptomics and extramacular retinal pigmented...
Mammals exhibit poor recovery after spinal cord injury (SCI), whereas non-mammalian vertebrates significant spontaneous SCI. The mechanisms underlying this difference have not been fully elucidated; therefore, the purpose of study was to investigate these mechanisms. Using comparative transcriptome analysis, we demonstrated that genes related cell cycle were significantly enriched in specifically dysregulated zebrafish Most cycle-related SCI down-regulated, possibly through activation e2f4....
Mitochondrial dysfunction has been implicated in various drug-induced toxicities and genetic disorders. Recently, the zebrafish emerged as a versatile animal model for both chemical screenings. Taking advantage of its transparency, vivo fluorescent imaging methods have developed to identify novel functions chemicals genes zebrafish. However, there not probes that can detect mitochondrial membrane potential living In this study, we identified cyanine dye called ZMJ214 detects from 4 8 days...
Exposure of rhodopsin to bright white light can induce photoreceptor cell damage and degeneration. However, a comprehensive understanding the mechanisms underlying light-induced retinopathy remains elusive. In this study, we performed comparative transcriptome analysis three rodent models retinopathy, identified 37 genes that are dysregulated in all models. Gene ontology revealed gene set is significantly associated with cytokine signaling axis composed signal transducer activator...
Learning better sentence embeddings leads to improved performance for natural language understanding tasks including semantic textual similarity (STS) and inference (NLI). As prior studies leverage large-scale labeled NLI datasets fine-tuning masked models yield embeddings, task languages other than English is often left behind. In this study, we directly compared two data augmentation techniques as potential solutions monolingual STS: (a) cross-lingual transfer that exploits resources alone...
Natural language generation methods have emerged as effective tools to help advertisers increase the number of online advertisements they produce. This survey entails a review research trends on this topic over past decade, from template-based extractive and abstractive approaches using neural networks. Additionally, key challenges directions revealed through survey, including metric optimization, faithfulness, diversity, multimodality, development benchmark datasets, are discussed.
An idea key to human-centric city planning is the reclamation of urban spaces from vehicles and their redesign for human activities. Aligned with this concept, study presents a framework network design. The developed based on multi-objective optimization model that designs pedestrian zones within center considering conflicting policy objectives. Design performance evaluated through interaction between design behavior travelers. A vehicle-pedestrian multimodal equilibrium assignment...
Objectives: Non-surgical treatment is an acceptable approach for managing appendiceal abscess in adults. However, it only applicable selected patients, and conversion to surgery mandatory failed conservative treatment. This study aimed determine the predictive factors unsuccessful outcomes. Methods: Of 594 patients with acute appendicitis, 34 (5.7%) diagnosed were initially treated conservatively. Patients divided into two groups: group, which was successfully antibiotics percutaneous...
症例は54歳，女性．主訴は腹痛．1994年に子宮体癌に対し子宮・付属器摘出術，傍大動脈リンパ節郭清，および術後補助化学療法を施行された．2007年9月に腹痛を認め近医で腹部CTを施行したところ，膵頭部前面に腫瘤性病変を認め，精査加療目的に当院を紹介された．画像上，径約3cmの辺縁平滑な楕円形の腫瘤が膵頭部と胃前庭部の間に存在し，内部は壊死性変化をきたしていた．膵との間には脂肪組織が介在するものの胃壁との境界が不明瞭な部位が存在した．FDG-PETでは同部位にのみ集積を認めた．胃gastrointestinal stromal tumorもしくは腸間膜腫瘍を疑い，腹腔鏡下腫瘍摘出術を施行した．術中所見で腫瘍は右胃大網動脈起始部に存在し，胃，膵との連続は認めなかった．病理組織診断では子宮体癌のリンパ節転移であった．今回われわれは子宮体癌術後13年目に右胃大網動脈領域リンパ節再発をきたした1例を経験したので，文献的考察を加えて報告する．
症例は49歳の男性で，胃検診で異常を認めたため精査を行ったところCTで胃大彎側のリンパ節腫大を伴う胃前庭部大彎と連続した12×8 cmの腫瘤を認めた．胃由来のgastrointestinal stromal cell tumor（以下，GISTと略記）の診断で手術を施行した．腫瘍は胃前庭部大彎より発生しており，右胃大網静脈領域（No6およびNo14v）のリンパ節腫大を認めた．リンパ節を術中迅速診断に提出したところCastleman病（Castleman’s disease；以下，CDと略記）の診断であったため胃局所切除術を行って手術を終了した．術後4か月後のCTでは再発所見を認めずリンパ節は消失していた．CDはリンパ濾胞の過形成に加え形質細胞が濾胞間に多数浸潤する組織所見を有する原因不明のリンパ増殖性疾患である．CDを合併したGISTの症例はこれまで報告がない．