A5103164433- Fluid Dynamics and Turbulent Flows
- Fluid Dynamics and Vibration Analysis
- Solar and Space Plasma Dynamics
- Mechanics and Biomechanics Studies
- Sports Dynamics and Biomechanics
- Optical measurement and interference techniques
- Oceanographic and Atmospheric Processes
- Analytical Chemistry and Sensors
- Intracranial Aneurysms: Treatment and Complications
- Particle Dynamics in Fluid Flows
- Cerebrovascular and Carotid Artery Diseases
- Heat Transfer Mechanisms
- Urinary Bladder and Prostate Research
- Neurosurgical Procedures and Complications
- Microstructure and Mechanical Properties of Steels
- Traumatic Brain Injury and Neurovascular Disturbances
- Aerodynamics and Fluid Dynamics Research
- Digital Holography and Microscopy
- Sports Performance and Training
- Glioma Diagnosis and Treatment
- Aerodynamics and Acoustics in Jet Flows
- Meteorological Phenomena and Simulations
- RNA Interference and Gene Delivery
- Magnetic confinement fusion research
- Geomagnetism and Paleomagnetism Studies
University of Electro-Communications
2015-2024
Fukuoka University
2021-2024
Fuji Heavy Industries Health Insurance Society Ota Memorial Hospital
2023-2024
National Institute of Advanced Industrial Science and Technology
2012-2024
Shimane University
2010-2021
Soka University
2016-2021
Sanyo (Japan)
2007-2019
Osaka University
1982-2018
Soka University of America
2013-2018
University of Shimane
2018
Abstract Purpose: Glioma stem cells (GSC) are a critical therapeutic target of glioblastoma multiforme (GBM). Experimental Design: The effects G-quadruplex ligand, telomestatin, were evaluated using patient-derived GSCs, non-stem tumor (non-GSC), and normal fetal neural precursors in vitro vivo. molecular targets telomestatin determined by immunofluorescence situ hybridization (iFISH) cDNA microarray. data then validated vivo functional assays, as well immunohistochemistry against 90...
A motion-capturing pressure-sensitive paint (PSP) method is introduced to capture unsteady motions and flow fields of objects. Conventionally, the intensity-based has been used cancel pressure-independent image a PSP measurement extract pressure-dependent image. However, this not applicable if changes in time. The new method, namely imaging two-color PSP-coated surface with high-speed color camera, acquires both images simultaneously. This reference luminescence blue established using an...
Objective: With the increasing prevalence of mechanical thrombectomy (MT) for large vessel occlusion strokes, encountering unruptured cerebral aneurysms (uANs) in MT target vessels has become more common, necessitating case accumulation to establish safety guidelines such cases. In this study, we aimed review and present cases uAN associated with at our hospital. Methods: Among 320 patients who underwent strokes hospital between January 2018 December 2021, selected analyzed various...
In Brief Study Design. Assessment of the potential use an immortalized human nucleus pulposus cell line as alternative source in transplantation therapy for intervertebral disc degeneration. Objectives. To evaluate effect transplanting into a degeneration model rabbits and to define whether it is capable becoming Summary Background Data. Interest has been growing several years, range different types have examined possible donor cells. addition, establishment novel that possesses some major...
Indoleamine 2,3-dioxygenase (IDO), a kynurenine pathway (KP) enzyme catalyzing oxidation of the essential amino acid tryptophan (Trp), is thought to be involved in immune resistance malignant tumors through T-cell inactivation caused by Trp depletion and metabolite accumulation. Human gliomas may use this strategy escape attack. The object study was investigate possibility IDO-dependent practicability using an IDO inhibitor together with anticancer drugs reserve without decreasing...
As part of a program to identify potent GPR40 agonists with drug-like properties suitable for clinical development, the incorporation polar substituents was explored intention decreasing lipophilicity our recently disclosed phenylpropanoic acid derivative 1. This would allow us mitigate cytotoxicity issues observed compound 1 and enable move away from multifunctional free fatty acid-like structure. Substitutions on 2',6'-dimethylbiphenyl ring were initially undertaken, which revealed...
Abstract Background Successful delivery of compounds to the brain and retina is a challenge in development therapeutic drugs imaging agents. This arises because internalization into restricted by blood–brain barrier (BBB) blood-retinal (BRB), respectively. Simple reliable vivo assays are necessary identify that can easily cross BBB BRB. Methods We developed six fluorescent indoline derivatives (IDs) examined their ability BRB zebrafish fluorescence imaging. These IDs were administered live...
Abstract Benzyloxymethyl-12-crown-4, a precursor of hydroxymethyl-12-crown-4, is prepared in an excellent yield by the reaction 3-benzyloxy-1,2-propanediol with 1,8-dichloro-3,6-dioxaoctane heterogeneous t-BuOLi/t-BuOH/LiBr·2H2O system. The hydrogenolysis presence p-toluenesulfonic acid leads to good hydroxymethyl-12-crown-4. sandwich-type 2:1 complexation Na+ 12-crown-4 and hydroxymethyl-12-crown-4 derivatives was discussed on basis stability constants solvent extraction CH2Cl2–water
Xenotransplantation studies are important tools for studying cancer biology, especially assaying tumor cell malignancy and providing information in vivo. Cancer stem-like cells (CSCs) have been identified many types to drive growth recurrence, from "keeping" "keep" resistant chemotherapy radiation therapy. In this study, we developed the xenotransplantation of CSCs derived leukemia solid lines using zebrafish models. adult zebrafish, investigated that xenografted stem (LSCs) K562 could...
The linear stability of unbounded strained vortices in a stably stratified rotating fluid is investigated theoretically. problem reduced to Matrix–Floquet problem, which solved numerically determine the characteristics. Coriolis force and buoyancy suppress subharmonic elliptical instability cyclonic weak anticyclonic vortices, whereas enhances that strong vortices. fundamental superharmonic modes occur, addition. They are due higher-order resonance. growth rate each shows complicated...
The linear stability of unbounded strained vortices in a stably stratified fluid is investigated theoretically. problem reduced to Floquet which solved numerically. three-dimensional elliptical instability Pierrehumbert type [Phys. Rev. Lett. 57, 2157 (1986)] shown be suppressed by the stable stratification and it disappears when Brunt–Väisälä frequency exceeds unity. On other hand, two classes new mode are found occur. One appears only less than 2, whereas persists for all values frequency....
Abstract Background The zebrafish visual system is a good research model because the retina very similar to that of humans in terms morphologies and functions. Studies have been facilitated by improvements imaging techniques. In vitro techniques such as immunohistochemistry vivo using transgenic proven useful for visualizing specific subtypes retinal cells. contrast, organic fluorescent molecules sphingolipids allows non-invasive staining visualization cells en masse . However, these also...
We have developed a novel method for growth factor analysis using commercial color ink jet printer to fabricate substrata patterned with factors. prepared insulin printed in simple pattern or containing multiple areas of varying quantities insulin. When we cultured the mouse myoblast cell line, C2C12, on insulin-patterned substrata, cells were grown same insulin-printed pattern. Cell culture latter demonstrated that quantity control deposition by is possible. For further applications,...
Disruption of the blood-brain barrier (BBB) can occur in various pathophysiological conditions. Administration extraneous tracers that pass disrupted, but not intact, BBB and detection extravasation have been widely used to assess disruption animal models. Although several fluorescent successfully used, administration these basically requires intravascular injection, which be laborious when using small animals such as zebrafish. To identify could easily administered into models visualize...
Abstract Many chemical reactions are accompanied by concerted phenomena, such as variance transition, structural changes, and particle formation. Various measurement techniques employed to understand the whole picture of phenomena. A combination small‐angle X‐ray scattering (SAXS), diffraction (XRD), absorption fine structure (XAFS) is useful for studying phenomena that occur, example, inside rechargeable batteries. This can cover large lengths from 1 Å several hundred nm. Operando...
The drag reduction effect of sinusoidal superhydrophobic surfaces (SHSs) in turbulent channel flow is investigated by means direct numerical simulations. microgrooves and micro-ridges SHS are represented free-slip no-slip conditions, respectively. simulations performed under constant pressure gradient condition at two friction Reynolds numbers 180 395. A parametric study shows that the rate increases gradually decreases as increasing wavelength SHSs. SHSs, except short case, increase more...
The reaction of Cu(ClO(4))·6H(2)O, Cu turnings, and 3,6-bis(2-pyridyl)-1,2,4,5-tetrazine (bptz) in Me(2)CO under C(2)H(4) afforded brownish-red needle crystals {[Cu(2)(bptz˙(-))(C(2)H(4))(2)](ClO(4))}(2) (1) as a minor product brown plate [Cu(2)(2,5-H(2)bptz)(C(2)H(4))(2)](ClO(4))(2)·2Me(2)CO (2). X-ray crystallographic study showed that complex 1 is composed two independent [Cu(2)(bptz˙(-))(C(2)H(4))(2)](+) cation moieties ClO(4)(-) anions. In both the moieties, each Cu(I) atom coordinated...
Establishment and characterization of a de novo cell line derived from human nucleus pulposus cells using recombinant simian virus 40 (SV40) adenovirus vector.To assess the feasibility procurement to evaluate character resultant outcome better understand nature cells.Despite recent advances in disc biologic research, fundamental cells, especially context lines, is still not well understood. Therefore, broad-based analysis these significant necessity. Because limited amount existing...