A5063441112- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Protein Tyrosine Phosphatases
- Hedgehog Signaling Pathway Studies
- Galectins and Cancer Biology
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Immune cells in cancer
- Intraperitoneal and Appendiceal Malignancies
- Histone Deacetylase Inhibitors Research
- Glycosylation and Glycoproteins Research
- Appendicitis Diagnosis and Management
- Immunotherapy and Immune Responses
- Chromatin Remodeling and Cancer
- Ubiquitin and proteasome pathways
Kyushu University
2018-2023
Columbia University Irving Medical Center
2022
Cancer Genetics (United States)
2022
Columbia University
2022
Kyushu Hospital
2018
In our previous study, we found that inhibition of protein tyrosine phosphatase non-receptor type 3 (PTPN3), which is expressed in lymphocytes, enhances lymphocyte activation, suggesting PTPN3 may act as an immune checkpoint molecule. However, also various cancers, and the biological significance cancer cells still not well understood, especially for lung neuroendocrine tumor (NET).Therefore, analyzed small cell examined potential inhibitory treatment a approach NET including (SCLC) large...
Small cell lung cancer (SCLC) is still a deadly type of for which there are few effective therapeutic strategies. Development new molecule targeting agent urgently desired. Previously we showed that recombination signal binding protein immunoglobulin-kappa-J region (RBPJ) and mastermind-like 3 (MAML3) targets pancreatic cancer. In the present study, analyzed whether RBPJ/MAML3 inhibition could also be strategy SCLC.Using silencing RBPJ/MAML3, proliferation, invasion, migration...
Pancreatic ductal adenocarcinoma (PDAC) is resistant to immunotherapy. As a factor of resistance, the dense fibrosis this cancer acts as barrier inhibit immune cell infiltration into tumor. We examined influence Hedgehog signal inhibitor, Patched 1-interacting peptide, on fibrosis, cells, and immunotherapeutic effects PDAC. found that peptide inhibited proliferation migration cancer-associated fibroblasts cells. Furthermore, reduced production extracellular matrix transforming growth β1 in...
We previously reported that Hedgehog (Hh) signal was enhanced in gallbladder cancer (GBC) and involved the induction of malignant phenotype GBC. In recent years, therapeutics target Hh signaling have focused on molecules downstream smoothened (SMO). The three transcription factors pathway, glioma‑associated oncogene homolog 1 (GLI1), GLI2, GLI3, function SMO, but their biological role GBC remains unclear. present study, significance GLI1, GLI3 were analyzed with aim developing novel...
In our comprehensive analysis of pancreatic cancer pathology, we found that the C4orf47 molecule was upregulated in hypoxic environments. is reported to be a centrosome-associated protein, but its biological significance completely unknown; therefore, assessed role cancer. We direct target HIF-1α and conditions, which it suppressed cell cycle inhibits proliferation through up-regulation repressors Fbxw-7, P27, p57; down-regulation promoters c-myc, cyclinD1, cyclinC. Furthermore, induced...
Background/Aim: Small-cell lung cancer (SCLC) remains one of deadliest types cancers. Cis-diamminedichloroplatinum (CDDP) is a key chemotherapeutic agent for SCLC, however, its therapeutic effect limited. Recently, hypoxia in the microenvironment has been suggested to influence therapy. Materials and Methods: Using small interfering RNA inhibition leukocyte common antigen-related interacting protein alpha 4 (liprin-α4), hypoxia-inducible factor (HIF)-1α, proliferation, invasion, migration...
Hypoxia is a characteristic feature of the tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC).We have recently explored new targeting molecules and pathways PDAC cells under hypoxic conditions.In this study, we performed microarray experiment to analyze genes up-regulated cell lines hypoxia compared normoxia, identified human family with sequence similarity 115, member C (FAM115C) as candidate gene for further study.Our data showed that FAM115C was overexpressed hypoxia,...
Although immune checkpoint inhibitors (ICIs) have emerged as new therapeutic options for refractory cancer, they are only effective in select patients. Tumor antigen-pulsed dendritic cell (DC) vaccine therapy activates tumor-specific cytotoxic T lymphocytes, making it an important immunotherapeutic strategy. Salivary ductal carcinoma (SDC) carries a poor prognosis, including long-term survival after metastasis or recurrence. In this study, we reported case of metastatic SDC that was treated...
Expression of the Notch family receptors is often upregulated in pancreatic ductal adenocarcinoma (PDAC). In this study, we focused on Notch4, which had not been investigated PDAC. We generated KC (
Objectives: Non-surgical treatment is an acceptable approach for managing appendiceal abscess in adults. However, it only applicable selected patients, and conversion to surgery mandatory failed conservative treatment. This study aimed determine the predictive factors unsuccessful outcomes. Methods: Of 594 patients with acute appendicitis, 34 (5.7%) diagnosed were initially treated conservatively. Patients divided into two groups: group, which was successfully antibiotics percutaneous...
Background/Aim: Hedgehog (HH) signalling is a potential therapeutic target for gallbladder cancer (GBC), and Mastermind-like 3 (MAML3) involved in the transcription of Smoothened (SMO), which key protein HH during hypoxia microenvironment. MAML3 NOTCH activator, are morphogenesis signalling. However, association between MAML3-NOTCH its role regulating GBC cells remain unknown. This study aimed to determine whether affects tumour aggressiveness under hypoxic conditions if could be new...
<div><p>Expression of the Notch family receptors is often upregulated in pancreatic ductal adenocarcinoma (PDAC). In this study, we focused on Notch4, which had not been investigated PDAC.</p><p>We generated KC (<i>LSL-Kras<sup>G12D</sup>;p48-Cre</i>), N4<i><sup>−</sup><sup>/</sup><sup>−</sup></i>KC...
<p>Supplementary Figure 1. Inactivation of Notch1 had no impact on pancreatic tumorigenesis driven by oncogenic Kras in the context p16 inactivation.</p><p>Supplementary 2. Histological analyses tissues PKC, N1+/- and N1fl/flPKC mice revealed significant differences.</p><p>Supplementary 3. Representative H&E from at 2 months age (PanIN, A, C, E) 5 (PDAC, B, D, F).</p><p>Supplementary 4. Comparative histological PanIN lesions 5. Notch4 reduced...
<div><p>Expression of the Notch family receptors is often upregulated in pancreatic ductal adenocarcinoma (PDAC). In this study, we focused on Notch4, which had not been investigated PDAC.</p><p>We generated KC (<i>LSL-Kras<sup>G12D</sup>;p48-Cre</i>), N4<i><sup>−</sup><sup>/</sup><sup>−</sup></i>KC...
<p>Supplementary Figure 1. Inactivation of Notch1 had no impact on pancreatic tumorigenesis driven by oncogenic Kras in the context p16 inactivation.</p><p>Supplementary 2. Histological analyses tissues PKC, N1+/- and N1fl/flPKC mice revealed significant differences.</p><p>Supplementary 3. Representative H&E from at 2 months age (PanIN, A, C, E) 5 (PDAC, B, D, F).</p><p>Supplementary 4. Comparative histological PanIN lesions 5. Notch4 reduced...
Previously, it was shown that Hedgehog (HH) signaling could be a therapeutic target for gallbladder cancer (GBC) and master mind like 3 (MAML3) is involved in Smoothened transcription, key protein HH under hypoxia, which microenvironment. MAML3 recently reported to NOTCH activator are morphogenesis signaling. We hypothesized of GBC. In our study, we used three cell lines 58 resected specimens. expression higher hypoxic conditions than normoxia the activation contributed proliferation,...