A5073619315- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Protein Kinase Regulation and GTPase Signaling
- HIV/AIDS drug development and treatment
- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- Biochemical and Molecular Research
- Protein Tyrosine Phosphatases
Columbia University Irving Medical Center
2022-2023
Cancer Genetics (United States)
2022-2023
Columbia University
2022-2023
Hackensack University Medical Center
2014
Acute graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic cell transplantation (HCT) and the main cause nonrelapse mortality during first 100 days post-transplant. Although GVHD can be prevented by extensive removal mature donor T cells from stem population, doing so eliminates any potential graft-versus-tumor (GVT) effect also mediated results in unacceptable rates cancer relapse. One solution to this problem separating development GVT response prevent...
Gastric cancer (GC) is among the deadliest diseases with countless incidences and deaths each year. Helicobacter pylori (Hp) primary type of microbe that colonizes stomach. In recent years, increasing evidence has demonstrated Hp infection one main risk factors for GC. Elucidating molecular mechanism how leads to GC will not only benefit treatment GC, but also boost development therapeutics other gastric disorders caused by infection. this study, we aimed identify innate immunity-related...
Novel C6-substituted pyrazolo[3,4-d]pyrimidine- and C2-substituted purine-based bisphosphonate (C6-PyraP-BP C2-Pur-BP, respectively) inhibitors of the human geranylgeranyl pyrophosphate synthase (hGGPPS) were designed evaluated for their ability to block proliferation multiple myeloma (MM), pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC) cells. Pyrazolo[3,4-d]pyrimidine analogs identified that induce selective intracellular target engagement leading apoptosis downregulate...
Expression of the Notch family receptors is often upregulated in pancreatic ductal adenocarcinoma (PDAC). In this study, we focused on Notch4, which had not been investigated PDAC. We generated KC (
<p>Supplementary Figure 1. Inactivation of Notch1 had no impact on pancreatic tumorigenesis driven by oncogenic Kras in the context p16 inactivation.</p><p>Supplementary 2. Histological analyses tissues PKC, N1+/- and N1fl/flPKC mice revealed significant differences.</p><p>Supplementary 3. Representative H&E from at 2 months age (PanIN, A, C, E) 5 (PDAC, B, D, F).</p><p>Supplementary 4. Comparative histological PanIN lesions 5. Notch4 reduced...
<div><p>Expression of the Notch family receptors is often upregulated in pancreatic ductal adenocarcinoma (PDAC). In this study, we focused on Notch4, which had not been investigated PDAC.</p><p>We generated KC (<i>LSL-Kras<sup>G12D</sup>;p48-Cre</i>), N4<i><sup>−</sup><sup>/</sup><sup>−</sup></i>KC...
<p>Supplementary Figure 1. Inactivation of Notch1 had no impact on pancreatic tumorigenesis driven by oncogenic Kras in the context p16 inactivation.</p><p>Supplementary 2. Histological analyses tissues PKC, N1+/- and N1fl/flPKC mice revealed significant differences.</p><p>Supplementary 3. Representative H&E from at 2 months age (PanIN, A, C, E) 5 (PDAC, B, D, F).</p><p>Supplementary 4. Comparative histological PanIN lesions 5. Notch4 reduced...
<div><p>Expression of the Notch family receptors is often upregulated in pancreatic ductal adenocarcinoma (PDAC). In this study, we focused on Notch4, which had not been investigated PDAC.</p><p>We generated KC (<i>LSL-Kras<sup>G12D</sup>;p48-Cre</i>), N4<i><sup>−</sup><sup>/</sup><sup>−</sup></i>KC...