A5103690127- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- NF-κB Signaling Pathways
- Gastric Cancer Management and Outcomes
- CAR-T cell therapy research
- Adenosine and Purinergic Signaling
- Phagocytosis and Immune Regulation
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Cytokine Signaling Pathways and Interactions
- Hedgehog Signaling Pathway Studies
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- HER2/EGFR in Cancer Research
- Cancer-related Molecular Pathways
- vaccines and immunoinformatics approaches
Saiseikai Fukuoka General Hospital
2014-2024
Cancer Clinic
2010-2023
Kyushu University
2001-2017
Nagaoka University of Technology
2002-2012
Osaka Kyoiku University
2003
Kurume University
2003
Tokyo Medical and Dental University
2000
Saga Medical School Hospital
1994-1996
Saint John's Health Center
1992-1994
Kitakyushu Municipal Medical Center
1988-1990
CD25+ FOXP3+CD4+ T cells (Treg) have been considered to play an important role in immune tolerance against several tumor antigens. It has also indicated that high-level expression of FOXP3 (FOXP3high) is sufficient confer suppressive activity normal non-Treg. Here, we showed for the first time vascular endothelial growth factor receptor 2 (VEGFR2) selectively expressed by FOXP3high but not FOXP3low Treg. Such VEGFR2+ Treg exist tissues including PBMC and malignant effusion-derived...
Nitric oxide (NO), the production of which is dependent on NO synthase (NOS), has been shown to contribute various pathogeneses in cancer. The aim this study was determine whether inducible (iNOS) overexpressed human colon carcinoma tissue, and produced tumor tissue.We investigated iNOS mRNA expression 24 tissue specimens by reverse transcription-polymerase chain reaction (RT-PCR). We then examined protein nitrotyrosine, indicates immunohistochemistry. possible immunosuppressive role cells...
Newly developed therapies for early gastric carcinoma attempt to consider patients' quality of life, but the applicability and effectiveness these treatments remain undetermined.Clinicopathologic data 612 consecutive patients with carcinoma, all whom were treated by D1 D2 gastrectomy, analyzed. Patients without lymph node metastases compared in relation age gender distributions, surgical procedures, histopathology tumors, 5-year prognosis, reference preoperative intraoperative...
Chemorefractory ovarian cancer has limited therapeutic options. Hence, new types of treatment including neoantigen-specific immunotherapy need to be investigated. Neoantigens represent promising targets for personalized immunotherapy. We here describe the clinical and immunological effects a neoantigen peptide-loaded DC-based in patient with recurrent chemoresistant cancer. A 71-year-old female chemorefractory malignant ascites received intranodal vaccination DCs loaded four peptides that...
Abstract Neoantigens are tumour-specific antigens that arise from non-synonymous mutations in tumour cells. However, their effect on immune responses the microenvironment remains unclear breast cancer. We performed whole exome and RNA sequencing of 31 fresh cancer tissues neoantigen prediction single nucleotide variants (nsSNVs) among exonic mutations. Neoantigen profiles were determined by predictive HLA binding affinity (IC 50 < 500 nM) mRNA expression with a read count ≥ 1. evaluated...
Background— The balance between apoptosis and proliferation of vascular smooth muscle cells (VSMCs) is believed to contribute the remodeling process. Cyclic AMP response element–binding protein (CREB) a critical transcription factor for survival neuronal T lymphocytes. However, role CREB in blood vessels incompletely characterized. Methods Results— Nuclear staining with Hoechst 33258 or propidium iodine showed an increase apoptotic activation caspase-3 VSMCs infected adenovirus expressing...
Reportedly, nitric oxide (NO) derived from alveolar macrophages (AMs) and increased serum phospholipase A2 (PLA2) activity are associated with the pathogenesis of lung injury in acute pancreatitis. The authors examined possibility that PLA2 causes, part, induction NO production by AMs pancreatitis.Pancreatitis was induced rats selective pancreatic duct ligation (SPL). were stimulated or SPL rat serum, without administration inhibitor quinacrine. Then measured Griess method, inducible...