A5046779818- Lung Cancer Treatments and Mutations
- Head and Neck Surgical Oncology
- Hedgehog Signaling Pathway Studies
- Neuroscience and Neuropharmacology Research
- Intensive Care Unit Cognitive Disorders
- Microtubule and mitosis dynamics
- Pain Mechanisms and Treatments
- Nerve injury and regeneration
- Ocular Surface and Contact Lens
- Anesthesia and Neurotoxicity Research
- Cancer Immunotherapy and Biomarkers
- Pediatric Pain Management Techniques
- PI3K/AKT/mTOR signaling in cancer
- Anesthesia and Sedative Agents
- Phytochemical compounds biological activities
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Biological Activity of Diterpenoids and Biflavonoids
- Hippo pathway signaling and YAP/TAZ
- Cancer Mechanisms and Therapy
- Ear and Head Tumors
- Nuclear Receptors and Signaling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Music Therapy and Health
- Osteoarthritis Treatment and Mechanisms
Xinqiao Hospital
2025
Army Medical University
2025
Nanjing University of Chinese Medicine
2025
Eye & ENT Hospital of Fudan University
2021-2024
Children's Hospital of Fudan University
2023
Shenyang Pharmaceutical University
2022-2023
Hainan Branch of People's Liberation Army General Hospital
2018-2023
Fudan University
2021
First Affiliated Hospital Zhejiang University
2021
Zunyi Medical University
2020
Abstract. Trajectory planning has undergone remarkable strides in recent times, especially the behavior prediction of traffic participants. Given that strong coupling conditions such as pedestrians, vehicles, and roads restrict interactive autonomous vehicles other participants, it become critical to design a trajectory algorithm based on scenarios for autonomous-driving technology. In this paper, we propose novel Transformer networks, data-driven method ingeniously harnesses dual-input...
Depression, a prevalent psychiatric disorder of ambiguous etiology and high heterogeneity, has been recently linked to the primary visual cortex (V1). However, precise circuits mediating impact V1 on depressive-like behaviors are poorly understood. Here, we demonstrate that V1, specifically lateral posterior nucleus thalamus (LP)-projecting glutamatergic subpopulation (GluV1→LP neurons), shows reduced activity after chronic restraint stress (CRS) in male mice, leading behaviors. Optogenetic...
Neuropathological studies have shown that the hippocampus is affected in Parkinson's disease (PD) with cognitive impairment. Our goal was to assess longitudinal volume change of different hippocampal subfields PD patients and without decline using magnetic resonance imaging (MRI).A total 28 nondemented 27 neurologically unimpaired elderly controls were enrolled this study, three-dimensional (3D) T1-weighted MRI performed. All followed up rescanned after 2 years divided into two groups:...
Abstract Dry eye disease (DED) affects nearly 55% of people worldwide; several studies have proposed that central sensitization and neuroinflammation may contribute to the developing corneal neuropathic pain DED, while underlying mechanisms this contribution remain be investigated. Excision extra orbital lacrimal glands established dry model. Corneal hypersensitivity was examined through chemical mechanical stimulation, open field test measured anxiety levels. Restingstate fMRI is a method...
The treatment of non-small cell lung cancer (NSCLC) patients harboring a proto-oncogene tyrosine-protein kinase c-ros oncogene 1 (ROS1) fusion gene has greatly benefited from the use crizotinib. However, drug resistance inevitably occurs after year treatment. Clinical studies have shown that with an L2026M mutation in ROS1 domain account for about 6% total number crizotinib-resistant cases, which is important group cannot be ignored. To explore mechanism involved, we constructed HLA class II...
The present study aimed to investigate the predictive value of pretreatment fibrinogen (FIB) levels in patients with cancer who received immunotherapy as a second-line treatment. A total 61 stage III-IV were included. cut-off FIB for predicting overall survival (OS) was determined by receiver operating characteristic curve analysis. prognostic on progression-free (PFS) and OS univariate multivariate analyses. Based point 3.47 g/l, divided into low (<3.47 g/l) high (≥3.47 groups. level more...
Procedural pain in neonates is associated with impaired neurodevelopment. Whether hearing development impaired, however, remains unknown. This study examined potential cause-and-effect relationship between neonatal and subsequent loss mice.Male C57BL/6J mouse pups received an intra-plantar injection of complete Freund's adjuvant on postnatal day 7 or repetitive needle prick stimuli from days 0-7. Mechanical thermal thresholds were tested 14 49. The auditory brainstem response test was used...
Summary Olfactory neuroblastoma (ONB) is an uncommon malignant tumor known to originate from the olfactory epithelial. The complex ecosystem of this pathology remained unclear. Here, we explored cellular components with ONB tumors based on scRNA profiles 96,325 single-cells derived 10 and 1 mucosa sample. We discovered 11 major cell types, including 6 immune cell, 3 stromal subtypes epithelial cluster in microenvironment (TME), identified 5 common expression programs cells. analyzed...
Background: Dilated cardiomyopathy (DCM) is a major cause of heart failure worldwide. The Z-line protein Cypher/Z-band alternatively spliced PDZ-motif (ZASP) closely associated with DCM, both clinically and in animal models. Our earlier work revealed Cypher/ZASP as PKA-anchoring (AKAP) that tethers PKA to phosphorylate target substrates. However, the downstream effectors regulated by AKAP their relevance DCM remain largely unknown. Methods Results: For identification candidate substrates,...
Abstract Rationale: Although most of non-small cell lung cancer (NSCLC) patients with ROS1-fusions respond to crizotinb, acquired resistance eventually develop. The next-generations ROS1 inhibitors have made some achievements, but the effects immunotherapy not been explored. Patient concerns: A 44-year-old Chinese women presented cough and dyspnea a history advanced adenocarcinoma. Diagnosis: PET/CT scan revealed primary tumors in bilateral lobes multiple metastases lymph nodes bones. And...
Purpose：Chronic corneal pain is the most common symptom of dry eye disease (DED), while central sensitization mechanisms underlying remain unclear. Methods：Excision extra orbital lacrimal glands was used to establish (DE) model. Tear volume measurements, fluorescein staining, hypersensitivity and anxiety behavior were tested after surgery. The amplitude low-frequency fluctuation (ALFF) by fMRI for determining brain functional activity. C-Fos, Brain-derived neurotrophic factor (BDNF),...
Abstract Purpose: Recent studies have shown that exposure to sevoflurane in developing brains causes neuronal apoptosis and cognitive dysfunction. “Necroptosis” is a novel pathway of necrosis. We introduced the caspase-specific inhibitor Z-VAD addition receptor-interacting protein kinase 1 (RIPK1) Nec-1, ascertain existence importance necroptosis. Methods: Sprague–Dawley rat pups postnatal day 7 were randomly assigned into one four groups: control, sevoflurane+Z-VAD, sevoflurane+Z-VAD+Nec-1...