A5109212473- Cardiovascular Function and Risk Factors
- Eicosanoids and Hypertension Pharmacology
- Circular RNAs in diseases
- Cardiomyopathy and Myosin Studies
- ATP Synthase and ATPases Research
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Cardiovascular Issues in Pregnancy
- MicroRNA in disease regulation
- Fuel Cells and Related Materials
- Pharmacogenetics and Drug Metabolism
- Fetal and Pediatric Neurological Disorders
- CRISPR and Genetic Engineering
- Cardiac electrophysiology and arrhythmias
- Doping in Sports
- Cardiac Fibrosis and Remodeling
- Cardiac Arrhythmias and Treatments
- Heart Failure Treatment and Management
- Pulmonary Hypertension Research and Treatments
- RNA Research and Splicing
- Atrial Fibrillation Management and Outcomes
- Cholesterol and Lipid Metabolism
- Heat shock proteins research
- Cell death mechanisms and regulation
First Affiliated Hospital Zhejiang University
2019-2024
First Affiliated Hospital of Xiamen University
2022-2023
Zhejiang University
2014-2023
Sir Run Run Shaw Hospital
2014
Background The causal direction and magnitude of the associations between telomere length (TL) cardiovascular diseases (CVDs) remain uncertain due to susceptibility reverse causation confounding. This study aimed investigate TL CVDs using Mendelian randomization (MR). Materials methods In this two-sample MR study, we identified 154 independent TL-associated genetic variants from a genome-wide association (GWAS) consisting 472,174 individuals (aged 40–69) in UK Biobank. Summary level data...
Abstract Idiopathic dilated cardiomyopathy (IDCM), characterized by ventricular dilation and impaired systolic function, is a primary resulting in heart failure. During contraction, the Z ‐line responsible for transmitting force between sarcomeres also hot spot muscle cell signalling. Mutations proteins have been linked to cardiomyopathies both humans mice. Actinin‐associated LIM protein (ALP) enigma homolog (ENH), encoded PDLIM3 PDLIM5 , are components of cytoskeleton localize ‐line. A or...
Abstract Aims Circular RNAs (circRNAs) are considered important regulators of biological processes, but their impact on atherosclerosis development, a key factor in coronary artery disease (CAD), has not been fully elucidated. We aimed to investigate potential use patients with CAD and the pathogenesis atherosclerosis. Methods results Patients stable angina (SA) or acute syndrome (ACS) controls were selected for transcriptomic screening quantification circRNAs blood cells. stained carotid...
Background: Dilated cardiomyopathy (DCM) is considered as the most common form of non-ischemic with a high mortality worldwide.Cytoskeleton protein Cypher plays an important role in maintaining cardiac function.Genetic studies human and animal models revealed that involved development DCM.However, underlying molecular mechanism not fully understood.Accumulating evidences suggest apoptosis myocytes may contribute to DCM.Thus, purpose this study define whether lack cardiomyocytes can elevate...
Background: Dilated cardiomyopathy (DCM) is a major cause of heart failure worldwide. The Z-line protein Cypher/Z-band alternatively spliced PDZ-motif (ZASP) closely associated with DCM, both clinically and in animal models. Our earlier work revealed Cypher/ZASP as PKA-anchoring (AKAP) that tethers PKA to phosphorylate target substrates. However, the downstream effectors regulated by AKAP their relevance DCM remain largely unknown. Methods Results: For identification candidate substrates,...
We aimed to study the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) risk model's prognostic value and relationship with left ventricular remodeling dilated cardiomyopathy.Dilated cardiomyopathy patients were prospectively recruited underwent clinical assessments. MAGGIC score was calculated. Patients followed up for adverse events echocardiography. Primary endpoints all-cause mortality first rehospitalization due heart failure. Secondary endpoint defined as a decline ejection...
Myocardial calcification is a rare condition, with only few reports in the literature. For first time, we report case of diffuse myocardial who underwent successful catheter ablation for persistent atrial fibrillation (AF). In this case, was recommended due to repeated hospitalization palpitation and heart failure, but preoperative computed tomography showed massive calcification. Electroanatomic mapping atrium performed Pentaray before ablation, which areas low voltage calcified region. As...
The association of the CYP2J2 G-50T polymorphism with coronary artery disease has been explored, but results remain controversial. Thus, a meta-analysis was conducted to provide comprehensive estimate this association. We selected ten articles encompassing 12 independent case-control studies 7063 cases and 10,453 controls for meta-analysis. Overall, we found significant associations between risk in three genetic models (allele model: odds ratio (OR) = 1.19, 95% confidence interval (CI)...
The objectives of this study were to use atrial volume tracking (AVT) evaluate fetal and function in normal fetuses that with congenital heart diseases. One hundred thirty-two normal, 5 case VSD, 4 cases TGA, TOF. According gestational age, fetus divided into three groups: 23 ∼ 28 weeks (group 1), 29 34 2) 35 40weeks 3). Using AVT, the maximal minimal volumes RA (and LA measured from time-atrial curves (TAVCs). For fetuses, RAmax ranged 1.21 ± 0.51 ml 2.35 0.86 2), 4.28 1.5 RAmin 0.8 0.35...
Background: Cholesterol efflux capacity dysfunction in macrophages is thought to be an important factor atherosclerosis. However, the molecular mechanism underlying this remains unclear.Methods: We first described characteristics of during atherosclerotic plaque formation hyperlipidaemic mice and patients with coronary artery disease through single-cell RNA sequencing analysis data. Then we extended our Apoe-/- fed a high fat diet, some which were treated tauroursodeoxycholic acid (TUDCA)....