A5103114003- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Head and Neck Surgical Oncology
- Corneal surgery and disorders
- Inflammasome and immune disorders
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Retinal Diseases and Treatments
- Retinopathy of Prematurity Studies
- Saffron Plant Research Studies
- Wound Healing and Treatments
- Inflammation biomarkers and pathways
- Gout, Hyperuricemia, Uric Acid
- Food Safety and Hygiene
- Viral Infections and Immunology Research
- Ocular Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Adenosine and Purinergic Signaling
- Advanced Glycation End Products research
- Advanced Chemical Sensor Technologies
- Olfactory and Sensory Function Studies
- Bee Products Chemical Analysis
- Cancer Cells and Metastasis
- Ophthalmology and Visual Impairment Studies
- Traditional Chinese Medicine Analysis
Eye & ENT Hospital of Fudan University
2019-2024
Hangzhou First People's Hospital
2024
Zhejiang University
2024
Fudan University
2022-2024
Shanghai University of Sport
2024
Beijing Center for Disease Prevention and Control
2024
Tianjin Medical University Cancer Institute and Hospital
2024
Beijing University of Chinese Medicine
2023
University of South China
2022
Wuhan University
2022
Tolerogenic dendritic cells (DCs) are associated with poor prognosis of sepsis. Matrix metalloproteinases (MMPs) have been shown to immunomodulatory effects. However, whether MMPs involved in the functional reprogramming DCs is unknown. The study aims investigate role sepsis-induced tolerance and potential mechanisms. A murine model late sepsis was induced by cecal ligation puncture (CLP). expression levels members MMP family were detected tolerogenic using microarray assessment. roles...
Chlorogenic acid (CA) has been discovered to regulate macrophage polarization in pneumonia. This study aims analyze the functional mechanism of CA alveolar (AM) and provide a theoretical basis for treatment Klebsiella pneumoniae (Kp)-induced Mice were infected with Kp, treated silent information regulator 1 (SIRT1) inhibitor (Selisistat). Mouse survival rate was recorded bacterial burden detected. AM pathologic change lung tissues evaluated. Expressions SIRT1 HMGB1 cytokine levels MH-S cells...
Purpose To evaluate whether patients with moderate–to–severe meibomian gland dysfunction (MGD) will benefit from increasing the number of intense pulsed light (IPL) treatment sessions.
Foot-and-mouth disease virus (FMDV) could cause acute infection in host cells, or they coexist with cells to generate persistent infection. In infection, the survive for a long time and be transmitted between different cells. case of FMDV-persistent cell line, there is remarkable significant cellular heterogeneity line due differences viral load individual within line. However, mechanisms are not well understood. It now generally accepted that multiple factors contribute coevolution viruses...
This study aimed to explore the oxidative stress-protective effect of crocetin on H2O2-mediated H9c2 myocardial cells through in vitro experiments, and further whether its mechanism is related impact mitophagy. also demonstrate therapeutic safflower acid stress cardiomyocytes Here, an H2O2-based model was constructed assessed degree injury by detecting levels lactate dehydrogenase (LDH), creatine kinase (CK), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione...
Purpose: To test the hypothesis that pterygium presents with both refractive and anatomical changes, especially short axial length. Methods: A retrospective, hospital-based cross-sectional study included 521 eyes from patients who were enrolled through a community survey by Shanghai Heping Eye Hospital was conducted. Patients primary in at least 1 eye considered group, those normal nonpterygium group. The prevalence length of pterygium, characteristics including spherical power, astigmatism,...
PURPOSE Serum/glucocorticoid-regulated kinase 1 (SGK1) has recently emerged as a critical regulator of inflammatory diseases. In this study, we examined SGK1 expression and its possible pathogenic roles in chronic rhinosinusitis (CRS). METHODS Immunohistochemistry, western blotting, Bio-Plex assay, enzyme-linked immunosorbent assays, quantitative real-time polymerase chain reaction were performed to assess protein gene levels. The mRNA levels interleukin-6 (IL-6) extracted from CRS database...
Summary Olfactory neuroblastoma (ONB) is an uncommon malignant tumor known to originate from the olfactory epithelial. The complex ecosystem of this pathology remained unclear. Here, we explored cellular components with ONB tumors based on scRNA profiles 96,325 single-cells derived 10 and 1 mucosa sample. We discovered 11 major cell types, including 6 immune cell, 3 stromal subtypes epithelial cluster in microenvironment (TME), identified 5 common expression programs cells. analyzed...
To evaluate the efficacy and safety of a novel sutureless AMT (amniotic membrane transplantation) or CAT (conjunctivolimbal autograft using fibrin glue for reconstructing corneoconjunctival surfaces primary pterygium associated with cysts.A prospective descriptive study was made period 1 January 2006-1 May 2009. Nine patients cysts underwent cyst excision followed by glue.During mean follow-up 8.00±0.67 months, all eyes maintained smooth stable corneal epithelial surface without recurrent...
Purpose To make appropriate therapeutic decisions of intense pulsed light (IPL) for meibomian gland dysfunction (MGD) patients.Methods Sixty patients with MGD stage 2–3 were enrolled in IPL Group1 and Self-hygiene Group; 110 3–4 included + MGX Group Group2. Patients groups received treatment once a month three times. Meibomian expression (MGX) was combined Group. (MG) functions, stage, associated ocular-surface indexes, response rate evaluated.Results Population characteristics clinical...
Background: Cancer-associated fibroblasts (CAFs) are highly heterogeneous in pancreatic ductal adenocarcinoma (PDAC). We previously reported that CAFs can acquire an endothelial phenotype under stress. Thus, we hypothesized there CAF subtypes expressing markers and influencing tumor progression.Methods: performed scRNA-seq, flow cytometry to identify the existence of CD144+CAFs. The prospective retrospective analysis were combined figure out correlation between CD144+CAFs clinical outcome....
To establish a new inflammatory animal model of meibomian gland dysfunction (MGD) in C57BL/6 mice.C57BL/6 mice were randomly divided into complete Freund's adjuvant (CFA) group (14 animals, 14 eyes), naphthazolin hydrochloride (NH) eyes) and control eyes). In CFA group, was used eyelid conjunctiva injection; NH eye drops twice day; injected with equal dose saline at the same time point site animals group. The orifices score (MGOS) evaluated on scale 0 to 3 middle five upper lower using slit...
Objective To observe the data of anterior chamber after posterior phakic intraocular lens （implantable contact lens, ICL） by ultrasonography method.Methods Anterior depth （ACD）, thick distance between surface ICL and was measured A-ultrasound ultrasound biomicroscopy （UBM）.Vision acuity （VA） pre-surgery, VA best corrected （BCVA） post-surgery were recorded.Results showed that ACD （2.54± 0.21 ）mm postoperatively （3.40± 0.30）mm preoperatively.There a statistically significant （t=22.648; P≤...