A5086408891- Glioma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Endometrial and Cervical Cancer Treatments
- Ferroptosis and cancer prognosis
- interferon and immune responses
- Signaling Pathways in Disease
- Advanced Vision and Imaging
- Inflammasome and immune disorders
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Glaucoma and retinal disorders
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Psoriasis: Treatment and Pathogenesis
- Inflammation biomarkers and pathways
- Ocular Surface and Contact Lens
- Cancer-related molecular mechanisms research
- Wound Healing and Treatments
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Advanced Glycation End Products research
- Cytokine Signaling Pathways and Interactions
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Cancer Cells and Metastasis
Siemens (China)
2024-2025
Tianjin Medical University General Hospital
2024
Wenzhou Medical University
2024
First Affiliated Hospital of Wenzhou Medical University
2024
Tianjin Medical University
2023
Tianjin Medical University Eye Hospital
2023
Abstract Glioblastoma is the most common primary intracranial malignant tumor in adults and has high morbidity mortality. TMEM158 been reported to promote progression of solid tumors. However, its potential role glioma still unclear. Here, we found that expression human cells core was significantly higher than noncancerous at edge using bioinformatics analysis. Cancer patients with GBMs harbored those WHO grade II or III gliomas. Interestingly, regardless grading, samples were IDH1-wild-type...
Glioma, especially glioblastoma patients, present highly heterogeneous and immunosuppressive microenvironment, leading to their poor response treatment survival. Targeting the tumor microenvironment is considered a promising therapeutic strategy. M2 macrophages are infiltrated in glioma tissue, even up 50% of total number bulk tissue cells. Here, we identified GPR65 as hub gene macrophage-related module through WGCNA analysis. The expression prognosis analysis suggested that was positively...
Tolerogenic dendritic cells (DCs) are associated with poor prognosis of sepsis. Matrix metalloproteinases (MMPs) have been shown to immunomodulatory effects. However, whether MMPs involved in the functional reprogramming DCs is unknown. The study aims investigate role sepsis-induced tolerance and potential mechanisms. A murine model late sepsis was induced by cecal ligation puncture (CLP). expression levels members MMP family were detected tolerogenic using microarray assessment. roles...
Abstract The tumor immunosuppressive microenvironment (IME) significantly affects occurrence, progression, and prognosis, but the underlying molecular mechanisms remain to make known. We investigated prognostic significance of PDPN its role in IME glioma. Weighted gene co-expression network analysis (WGCNA) found closely related IDH wildtype status higher immune score. Correlation suggested was highly positively relevant checkpoints expression block responding status. together with...
Abstract Non-SMC (Structural Maintenance of Chromosomes) condensin I complex subunit H (NCAPH) has been shown to facilitate progression and predict adverse prognostic outcome in many cancer types. However, the function NCAPH gliomas is still unclear. Series experiments were taken uncover glioma. The expression potential mechanism regulating glioma was verified by bioinformatics analysis. Lentiviral transfection used for establishment loss-of-function gain-of-function cell lines. CCK-8 assay...
<title>Abstract</title> Glioblastoma, IDH-wildtype (GBM, WHO grade 4) is the most common and lethal type of brain cancer that hard to cure. Among 3 subtypes GBM, mesenchymal GBM characterized by therapeutic resistance poor outcomes. Here, we found both STAT3 NF-κB pathways are abnormally activated in patients with higher expression had a prognosis TCGA database. Using inhibitor, Stattic, suppress signaling cells. However, it was observed Stattic alone leads compensatory activation signaling....
Glioma is an intracranial tumor characterized by high mortality and recurrence rates. In the present study, association of TRPM8 channel-associated factor 2 (TCAF2) in glioma was investigated using bioinformatics, showing significant relationships with age, WHO grade, IDH, 1p/19q status, as well being independent predictor prognosis. Immunohistochemistry a sample microarray showed markedly increased TCAF2 expression glioblastoma relative to lower-grade glioma, elevated predominating center....
The NerveStitcher demonstrated that a set of in vivo confocal microscopy (IVCM) images can be merged under framework graph convolutional neural network. However, the high similarity nerval structure on IVCM image results mis-stitching when internal sequence happen to drop. Particularly large gap between pair adjacent images, sometimes cannot detected. In this paper, we advance concept global optical flow and intergrate it existing framework. improvements algorithm robustness are caused by...