A5101477113- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cancer-related molecular mechanisms research
- NF-κB Signaling Pathways
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Estrogen and related hormone effects
- Prostate Cancer Treatment and Research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Reconstructive Surgery and Microvascular Techniques
- Dermatologic Treatments and Research
- Cancer Research and Treatments
- Advanced Data Storage Technologies
- Cancer, Hypoxia, and Metabolism
- Vitamin D Research Studies
- Ubiquitin and proteasome pathways
- Antenna Design and Optimization
- Pediatric Urology and Nephrology Studies
- Per- and polyfluoroalkyl substances research
- Peer-to-Peer Network Technologies
- PI3K/AKT/mTOR signaling in cancer
- Medicinal Plants and Bioactive Compounds
- Vascular anomalies and interventions
- Reconstructive Facial Surgery Techniques
Sun Yat-sen University
2012-2025
Fudan University
2020-2025
Peking University
2024
Peking University First Hospital
2024
Tongji University
2024
Xinxiang Medical University
2024
China University of Geosciences (Beijing)
2024
Shanghai Tenth People's Hospital
2024
Chinese Academy of Sciences
2009-2023
Wenzhou Hospital of Traditional Chinese Medicine
2023
Abstract A small population of cells with stem cell‐like properties in prostate cancer ( PC a), called (Pr CSC s) or stemness‐high cells, displays highly tumorigenic and metastatic features may be responsible for the therapy resistance. molecule, napabucasin BBI 608), recently have been identified suppression a variety cancers. However, effects on as well Pr s isolated from not yet defined. The effect cell proliferation, colony formation, migration vitro were measured by MTS , formation...
Abstract Glioblastoma is the most common primary intracranial malignant tumor in adults and has high morbidity mortality. TMEM158 been reported to promote progression of solid tumors. However, its potential role glioma still unclear. Here, we found that expression human cells core was significantly higher than noncancerous at edge using bioinformatics analysis. Cancer patients with GBMs harbored those WHO grade II or III gliomas. Interestingly, regardless grading, samples were IDH1-wild-type...
ABSTRACT One main cause of persistent back discomfort is intervertebral disc degeneration (IDD), with inflammation and extracellular matrix (ECM) degradation playing critical roles. This study investigates the role ZIP8 , a zinc transporter, in IDD pathogenesis, focusing on its effects inflammatory responses, ECM Wnt/β‐catenin signalling pathway. was identified as hub gene from GSE27494 dataset through bioinformatics analysis. The investigated nucleus pulposus (NP) cells RAW 264.7...
BACKGROUND Nuclear factor κB (NFκB) signaling is strongly associated with tumor progression, and studies have shown that SHANK‐associated RH domain interacting protein (SHARPIN) crucial for NFκB pathway activation. However, the expression functions of SHARPIN in prostate cancer (PCa) not yet been defined. METHODS The PCa cell lines tissues was evaluated western blotting, quantitative real‐time polymerase chain reaction, immunohistochemistry. After silenced lines, blots were used to confirm...
Transgelin is an actin-binding protein that regulates cell motility and other important cellular functions. Previous studies have suggested transgelin expression associated with cancer development progression, but its specific role in colorectal (CRC) remains controversial. We analyzed of candidate downstream target, tensin 1 (TNS1), CRC patients using the ONCOMINE, Protein Atlas, OncoLnc databases. TNS1 mRNA levels were higher lines than normal tissues cells. Survival analyses database...
Regulated activation of p38 is crucial for cell proliferation, survival, and metabolism. Our previous studies had showed that prostate specific membrane antigen (PSMA) can facilitate the migration, survival LNCaP cancer line, but mechanisms are poorly defined.Our cells been stably transfected with lentivirus-mediated shRNA PSMA silencing in study. We first testify efficacy knockdown our line. Then using this (-) we compared expression P-p38 by Western blotting among groups. Furthermore, also...
For the digestive system, there exists one common malignant tumor, known as gastric cancer. It is third most prevalent type of tumor among different tumors worldwide. has been reported that long noncoding RNAs (lncRNAs), participate in various biological processes However, are still many lncRNAs with unknown functions, and we discovered a novel lncRNA designated FBXO18-AS. Whether lncRNAFBXO18-AS participates cancer progression unknown. Bioinformatic analysis, immunohistochemistry, Western...
Tables are prevalent in real-world databases, requiring significant time and effort for humans to analyze manipulate. The advancements large language models (LLMs) have made it possible interact with tables using natural input, bringing this capability closer reality. In paper, we present TableGPT, a unified fine-tuned framework that enables LLMs understand operate on external functional commands. It introduces the seamlessly tables, enabling wide range of functionalities such as question...
The objective of this study is to establish self-sequential longitudinal reference intervals thyroid function in normal pregnant women. According the selection criteria, 301 cases were taken as population a range. Meanwhile, 150 healthy women selected non-pregnant control group. To their own intervals, we collected samples five times every case throughout gestation (including first trimester, second third prenatal and postpartum), detected levels stimulating hormone (TSH), free thyroxine...
Humans have had a significant impact on the terrestrial pedosphere through activities such as agriculture and urbanization. The effects of human land use related environmental changes were investigated point areal studies surrounding Meiliang Bay, which is an open area extreme eutrophication in Taihu Lake, China. This study used remote sensing environmental-tracer profiles [total nitrogen (TN), total phosphorus (TP), organic carbon (TOC), grain size, geochemical parameters] to determine...
Osteosarcoma is a malignant tumor that seriously threatens human health. Numerous studies have pointed out the potential of long noncoding RNAs (lncRNAs) as new therapeutic targets for various cancers. Therefore, we mainly investigate whether there type lncRNA pathway involved in regulating development osteosarcoma. The present study shows higher expression levels LINC00511 correlates to shorter overall survival and disease-free time patients with sarcoma. It significantly clinical samples...
MicroRNAs (miRNAs) are known to have regulatory roles in the osteogenic differentiation of various mesenchymal stem cells (MSCs), although their role on human adipose‑derived (hADSCs) remains unclear. The aim present study was investigate biological function and underlying molecular mechanism miRNAs regulating hADSCs using microarray assay. differentiated into osteoblasts under culture with medium, an increase observed calcium deposits alkaline phosphatase activity. mRNA levels bone...
BACKGROUND SHARPIN, SHANK‐associated RH domain interacting protein, associates with a linear ubiquitin chain assembly complex (LUBAC) to regulate inflammation and immunity. It has been reported that SHARPIN is highly expressed in several human tumors including ovarian cancer liver cancer. We found also prostate cell lines of DU145, LNCAP, PC‐3. Suppression caused an inhibition NF‐κB signal decreases tumorigenesis cultured cells NOD/SCID mouse model. Overexpression promoted growth reduced...
The traditional grey wolf algorithm is widely used for feature selection. However, within complex multi-dimensional problems, the prone to reach locally optimal solutions and premature convergence. In this paper, a threshold binary optimizer based on multi-elite interaction selection (MTBGWO) proposed. Firstly, multi-population topology adopted enhance population's diversity improving search space utilization. Secondly, an information learning strategy update of sub-population elite position...