A5026034758- Spine and Intervertebral Disc Pathology
- Management of metastatic bone disease
- Spinal Fractures and Fixation Techniques
- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Bone and Joint Diseases
- Bone health and treatments
- Musculoskeletal pain and rehabilitation
- Cervical and Thoracic Myelopathy
- Advanced biosensing and bioanalysis techniques
- Chemokine receptors and signaling
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Spinal Hematomas and Complications
- Orthopaedic implants and arthroplasty
- Circular RNAs in diseases
- Innovations in Medical Education
- Inflammasome and immune disorders
- Orthopedic Infections and Treatments
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Medical Imaging and Analysis
- Signaling Pathways in Disease
- Osteoarthritis Treatment and Mechanisms
- Evaluation and Optimization Models
Fudan University
2012-2025
Lanzhou Jiaotong University
2025
Minhang District Central Hospital
2020-2024
The First Affiliated Hospital, Sun Yat-sen University
2016-2024
Zhongshan Hospital
2016-2024
Sun Yat-sen University
2016-2024
Iowa State University
2011
<title>Abstract</title> Concrete is the most widely used material globally, but it prone to micro-cracks, which negatively affect strength and durability of concrete structures. Therefore, there significant interest in developing materials that can spontaneously repair these micro-cracks. Drawing inspiration from self-healing properties found organisms, researchers have proposed a microcapsule-based system capable improving strength. This study examines impact microcapsule parameters on...
ABSTRACT One main cause of persistent back discomfort is intervertebral disc degeneration (IDD), with inflammation and extracellular matrix (ECM) degradation playing critical roles. This study investigates the role ZIP8 , a zinc transporter, in IDD pathogenesis, focusing on its effects inflammatory responses, ECM Wnt/β‐catenin signalling pathway. was identified as hub gene from GSE27494 dataset through bioinformatics analysis. The investigated nucleus pulposus (NP) cells RAW 264.7...
Study design: This is an experimental animal study. Objective: The objective of this study was to compare anterior cervical discectomy and interbody fusion a novel polylactide/nano-sized β-tricalcium phosphate (PLA/nβ-TCP) bioabsorbable self-retaining cage (BCFC) with autologous bone graft polyetheretherketone (PEEK) cages. Background: Although PLA cages have potential advantages compared traditional materials, they are not currently routinely used in spine surgery because undesirable...
The aim of our study was to investigate the general mechanism spinal metastases from five different primary cancers: lung cancer, breast liver prostate and kidney cancer.From microarray analysis validation by real-time polymerase chain reaction, CX3C chemokine ligand 1 (CX3CL1) appeared be a potential widely involved in process metastases. Further studies revealed that, compared with normal controls, serum samples patients (P < 0.01), 0.05) contained significantly higher levels CX3CL1,...
As a subclass of noncoding RNAs, circular RNAs (circRNAs) have been demonstrated to play critical role in regulating gene expression eukaryotes. Recent studies revealed the pivotal functions circRNAs cancer progression. Nevertheless, how participate osteosarcoma (OS) development and progression are not well understood. In present study, we identified circRNA circFAT1(e2) with an upregulated level OS tissues. By functional experiments, found that depletion significantly suppressed...
This study aimed to elucidate the roles of microRNA (miR)-4738-3p and collagen type I alpha 2 chain (COL1A2) gene in pathogenesis osteoarthritis (OA) through bioinformatics analysis cellular assays. The GSE55235 dataset was analyzed using weighted co-expression network (WGCNA) method identify modules associated with OA. Key overlapping genes were identified from these GSE55235-differential expressed (DEGs). expression levels selected determined C28/I2 cells quantitative real-time polymerase...
Osteoporosis (OP) has the characteristics of a systematically impaired bone mass, strength, and microstructure. Long non-coding RNAs (lncRNAs) are longer than 200 nt, their functions in osteoporosis is yet not completely understood. We first harvested marrow mesenchymal stem cells (BMSCs) from ovariectomy (OVX) sham mice. Then, we analyzed differential expressions lncRNAs messenger (mRNAs) constructed lncRNA-mRNA coexpression network order to identify function lncRNA osteoporosis. Totally,...
Aminopeptidase N, as a target for drug discovery, shows marked relationships with many diseases, especially liver injury and cancer. Here, we explored chemiluminescence (CL) probe sensing APN by tethering the APN-specific substrate group to ortho-acrylated phenoxy-dioxetane scaffold. In this way, two CL probes (APN-CL BAPN-CL) were designed noncapped leucine butoxy-carbonyl capped protecting preserve chemiexcitation energy. The uncovered was demonstrated be essential detection of activity...
The present study aimed to identify the underlying molecular mechanisms associated with spinal metastases. Gene expression profiles in cancellous bone samples from spines of five patients metastases, different primary cancers, and three normal control were measured using microarray analysis subsequently compared. differentially expressed genes (DEGs) identified filtered bioinformatics analyses followed by cluster analysis, gene ontology (GO) term Kyoto Encyclopedia Genes Genomes pathway...
Abstract An imbalance between the adipogenesis and osteogenesis of bone marrow mesenchymal stem cells (BMSCs) is considered basic pathogenesis osteoporosis. Although actin cytoskeleton remodelling plays a crucial role in differentiation BMSCs, BMSCs postmenopausal osteoporosis (PMOP) has remained elusive. Glia maturation factor-beta (GMFB) unique polymerization/depolymerization cycles actin. We observed that GMFB expression was increased tissue from both ovariectomized (OVX) rats PMOP...
The study aimed to retrospectively evaluate the accuracy and value of magnetic resonance imaging (MRI) in predicting pedicle involvement for patients with spine metastases.Forty-five a vertebral metastasis encroaching at least one were studied using MRI before surgery regularly after surgery. Patients categorized on basis their numbers (Group 1: was involved, n = 23; Group 2: two pedicles 22). diagnostic calculated, comparisons intraoperative blood loss recurrence rate between groups...
Abstract Aim To provide guidance for appropriate imaging examinations diagnosing spinal tumors or tumor‐like lesions. Methods A total of 121 patients with suspected were included this retrospective study. Each patient underwent ≥2 examinations, including computerized tomography (CT), magnetic resonance (MR), and/or emission computed (ECT). All diagnosed by pathology after core needle surgical biopsies. The results compared those pathological using paired chi‐squared tests, and each other....
Abstract Objective The activation of NLRP3 inflammasome is critical for rheumatoid arthritis (RA), however, the role gasdermin D (GSDMD), a newly identified pyroptosis executioner downstream NLRP3/ASC/Caspase-1, in RA has not been well defined. Methods Genetically susceptible mice (DBA/1J) are immunized with type II bovine collagen emulsion complete Freund's adjuvant (CFA). Peripheral blood neutrophils were isolated from healthy volunteers and patients; cells treated serum patients. GSDMD...
Objective To confirm the vancomycin loaded gelatin/β-TCP composite porous scaffolds could be used as sus-tained-release system, and investigate its efficiency of eliminating infections repairing bone defects for treatment infect-ed in rabbit. Methods The biodegradable gelatin sponge containing different contents (0, 10%, 30%, 50%) β-tricalcium phosphate ceramic (β-TCP) was prepared controlled-release labeled with G-0 TCP, G-10 G-30 TCP G-50 respectively. Examinations scanning electron...