A5101359026- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Botulinum Toxin and Related Neurological Disorders
- Cyclopropane Reaction Mechanisms
- Asymmetric Hydrogenation and Catalysis
- Cognitive Functions and Memory
- Renal Transplantation Outcomes and Treatments
- Pregnancy-related medical research
- Acute Ischemic Stroke Management
- Cerebral Palsy and Movement Disorders
- Cancer-related gene regulation
- Dementia and Cognitive Impairment Research
- Cardiovascular Health and Disease Prevention
- Renal and Vascular Pathologies
- Animal Virus Infections Studies
- Traditional Chinese Medicine Studies
- Hepatitis B Virus Studies
- HVDC Systems and Fault Protection
- Renal Diseases and Glomerulopathies
- Crystallography and molecular interactions
- Neurological Disorders and Treatments
- Stroke Rehabilitation and Recovery
- Neonatal and fetal brain pathology
Fudan University
2025
Northern Jiangsu People's Hospital
2014-2023
China National Chemical Corporation (China)
2023
China Pharmaceutical University
2023
82th Hospital of Pla
2007
M6A (N6-methyladenosine) plays a significant role in regulating RNA processing, splicing, nucleation, translation, and stability. AlkB homologue 5 (ALKBH5) is an Fe(II)/2-oxoglutarate (2-OG)-dependent dioxygenase that demethylates mono- or dimethylated adenosines. ALKBH5 can be regarded as oncogenic factor for various human cancers. However, the discovery of potent selective inhibitors remains challenge. We identified DDO-2728 novel inhibitor by structure-based virtual screening...
ABSTRACT One main cause of persistent back discomfort is intervertebral disc degeneration (IDD), with inflammation and extracellular matrix (ECM) degradation playing critical roles. This study investigates the role ZIP8 , a zinc transporter, in IDD pathogenesis, focusing on its effects inflammatory responses, ECM Wnt/β‐catenin signalling pathway. was identified as hub gene from GSE27494 dataset through bioinformatics analysis. The investigated nucleus pulposus (NP) cells RAW 264.7...
Takayasu arteritis (TAK) is a chronic inflammatory arteritis. It most often affects non-specific large vessel progressively, such as the aorta and its branches. The diagnosis in TAK typically delayed. Isolated pulmonary artery involvement uncommon. Owing to rarity, challenging requires an integrated approach comprising clinical imaging findings. In order facilitate early of for clinicians, wider use non-invasive impacting this.In this report, we present characteristics rare isolated...
Symptomatic carotid stenosis is closely associated with ischemic stroke,its treatment strategies include risk factor control,medical therapy,and revascularization.This article reviews and summarizes the clinical research of methods in recent years,such as symptomatic related antiplatelet therapy,antihypertensive treatment,lipid-lowering therapy,carotid endartereetomy stenting,as well recommended by guidelines. Key words: Carotid Stenosis; Endarterectomy, Carotid; Angioplasty; ...
Abstract 6,6-Dimethyl-3-azabicyclo [3.1.0]hexane (6,6-DMABH) is a fundamental building block in numerous antiviral drugs, including boceprevir and pf-07321332. To enable more efficient synthesis of 6,6-DMABH, we developed an innovative approach that utilizes the intramolecular cyclopropanation alpha-diazoacetates via Ru (II) catalysis Gabriel synthesis. Our method enabled 6,6-DMABH from 3-methyl-2-butenol seven distinct steps, yielding total 28%.
Objective To explore the effects of rehabilitation starting at different stages on gross motor function infants with high risk cerebral palsy. Methods 214 neonates (117 boys and 97 girls) least 14 days old a neonatal behavioral neurological assessment scale (NBNA) score less than 35 were randomly divided into four groups. They received 2 to 3 weeks in hospital, followed by 4 6 family then another hospital rehabilitation. The three groups started this course treatment times: beginning...