A5100568095- Soil Carbon and Nitrogen Dynamics
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Forest Ecology and Biodiversity Studies
- Motivation and Self-Concept in Sports
- Environmental Philosophy and Ethics
- Land Use and Ecosystem Services
- Sport Psychology and Performance
- Anorectal Disease Treatments and Outcomes
- Ferroptosis and cancer prognosis
- Colorectal Cancer Screening and Detection
- Cardiac Ischemia and Reperfusion
- Urban Green Space and Health
- Income, Poverty, and Inequality
- Physical Education and Pedagogy
- Glioma Diagnosis and Treatment
- Spectroscopy and Quantum Chemical Studies
- Plant nutrient uptake and metabolism
- HVDC Systems and Fault Protection
- Appendicitis Diagnosis and Management
- Urban, Neighborhood, and Segregation Studies
- Cancer-related gene regulation
- Reconstructive Surgery and Microvascular Techniques
- Psychology of Moral and Emotional Judgment
- Bioactive Compounds and Antitumor Agents
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2025
Shandong University
2022-2025
China Pharmaceutical University
2023
State Key Laboratory of Natural Medicine
2023
East China Normal University
2022-2023
Hangzhou Medical College
2023
XinHua Hospital
2022
Shanghai Jiao Tong University
2022
Sichuan University
2022
West China Hospital of Sichuan University
2022
M6A (N6-methyladenosine) plays a significant role in regulating RNA processing, splicing, nucleation, translation, and stability. AlkB homologue 5 (ALKBH5) is an Fe(II)/2-oxoglutarate (2-OG)-dependent dioxygenase that demethylates mono- or dimethylated adenosines. ALKBH5 can be regarded as oncogenic factor for various human cancers. However, the discovery of potent selective inhibitors remains challenge. We identified DDO-2728 novel inhibitor by structure-based virtual screening...
Reconstruction of pelvis girdle stability after tumor-induced hemipelvectomy remains challenging. We surgically treated 13 patients with custom-made, three-dimensional printed hemipelvic prostheses. aim to identify the preliminary outcomes for who have been managed more mixed regions prosthetic pelvic reconstruction and feasibility two reconstructive systems.Seven male 6 female at our center between January 2019 May 2021 were included. There 11 primary sarcomas 2 solitary bone metastases....
Abstract Objective This study investigates the impact of Titin (TTN) gene mutations on radiotherapy sensitivity in rectum adenocarcinoma (READ) by examining changes tumour immune microenvironment. Methods Data expression and READ were obtained from The Cancer Genome Atlas (TCGA) International Consortium (ICGC) databases. Bioinformatics analysis explored correlation between TTN cell infiltration. In vitro, lentiviral vectors used to assess mutations' effects ANKRD1 two lines. was...
Abstract Background Glioblastoma (GBM) represents a complex ecosystem characterized by numerous interactions between tumor cells and the surrounding microenvironment (TME). Here, we show that WNT10A, member of WNT family, plays an important role in GBM growth where its influence is mediated via both autocrine paracrine pathways thereby stimulating not only but also normal cell types within Methods In silico analysis was performed to identify high-expressing family members GBM. Knockdown...
Abstract The multidimensional dynamics of biodiversity and ecosystem function during the rewilding Mediterranean forests remain poorly understood, limiting our capacity to predict how future restoration efforts may help mitigate climate change. Here, we investigated changes in multiple dimensions services a 120‐year forest succession after harvest identify potential trade‐offs function, further assess link between above below‐ground function. We found positive influence successional age on...
This study intends to discuss the effects of university PE teachers' leadership styles and classroom climate on learning motivation for basketball course. University students in Guangdong Province, as research objects, are surveyed with teacher style scale, physical education scale. Total 589 valid copies questionnaire analyzed Multiple Stepwise Regression Analysis. The results show that support, affinity, charismatic leadership, intellectual stimulation could positively predict intrinsic...
Glioblastoma multiforme (GBM) is a common central neural system malignant tumor among adults. Alongside its microscopic spread, immunosuppression in the microenvironment also induces refractoriness, which makes immunotherapy for GBM particularly important. Unfortunately, traditional immune checkpoint inhibitors (ICIs) often show limited therapeutic effects clinical trials, and new strategies or targets are urgently needed. TNFSF14/LIGHT novel molecule that plays essential roles both innate...
Successive planting and monoculture, as common forest management methods, are widely used globally, especially in Chinese fir plantations the subtropical areas of southern China. Although soil fertility depletion productivity decline caused by successive have been reported, underlying mechanism is still ambiguous. In this study, composition diversity microorganisms (rhizosphere bulk soils) seedlings exposed to soils (first-generation seedings, FCP. second-generation SCP. third-generation...
Abstract Objective This study aimed to evaluate the impact of postoperative complications on long-term survival in patients with peritoneal metastasis (PM) arising from colorectal cancer (CRC) treated cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Methods Patients PM CRC CRS HIPEC were systematically reviewed at China National Cancer Center Huanxing Hospital June 2017 2019. High-grade that occurred within 30 days defined as grade 3 4 events according...
Club members' cohesion has become an important indicator to enhance the operating performance of student basketball clubs in colleges and universities. With questionnaire survey, club members universities south China region are selected as research objects. The self-compiled is revised after pretest formal questionnaire. Total 500 copies distributed, 386 valid. data analyzed with structural equation modeling (SEM), results summarized followings. 1. participation motivation presents...
Transverse colon cancer accounts for about 10% of all colonic cancers. The resection cancers in the transverse is technically more challenging, compared with other locations because variable anatomy middle colic vessels demands excellent surgical skills and anatomical location related to major organs. We report a novel laparoscopic technique first time used surgery which combines total intracorporeal anastomosis natural orifice specimen extraction solve problems traditional surgery. A...
CHCHD2 mutations have been reported to cause Parkinson's disease (PD) by a loss of function in mitochondria. Most mutations, however, were missense, which was not the perfect model for study haploinsufficiency. Here, truncated mutation, p.Pro53Alafs*38, identified one familial early-onset PD patient. We generated human-induced pluripotent stem cell (iPSC) line WCHSCUi001-A from this The iPSCs resembled human embryonic cells, expressed pluripotency markers, exhibited normal karyotype and...
Root exudates are an important pathway for plant-microbial interactions and highly sensitive to climate change. However, how extreme drought affects root exudate its components, as well species-specific difference in response magnitude direction, poorly understood. In this study, exudation rates of total carbon (C) components (e.g., sugar, organic acid, amino acid) were measured under the control treatments (i.e., 70% throughfall reduction) by situ collection four tree species with different...