A5100628739- Ziziphus Jujuba Studies and Applications
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Circular RNAs in diseases
- Cardiovascular Health and Risk Factors
- Metabolomics and Mass Spectrometry Studies
- Plant Molecular Biology Research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Neurosurgical Procedures and Complications
- Intracranial Aneurysms: Treatment and Complications
- Monoclonal and Polyclonal Antibodies Research
- Plant Physiology and Cultivation Studies
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- Microbial Community Ecology and Physiology
- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related gene regulation
- Remote Sensing in Agriculture
- Remote Sensing and Land Use
- Traumatic Brain Injury and Neurovascular Disturbances
- Plant and animal studies
Shandong University
2013-2025
Edith Cowan University
2018-2025
South China Agricultural University
2020-2025
Northwest A&F University
2008-2024
Yunnan University of Traditional Chinese Medicine
2024
Dezhou University
2024
Qilu Hospital of Shandong University
2007-2024
University of Waterloo
2024
Key Laboratory of Guangdong Province
2022-2023
Beijing Normal University
2022-2023
Xiaowen Sun and colleagues report the whole-genome sequencing of common carp, Cyprinus carpio. They also resequenced 33 representative accessions from a worldwide collection provide insights into population structure evolution. The carpio, is one most important cyprinid species globally accounts for 10% freshwater aquaculture production. Here we present draft genome domesticated C. carpio (strain Songpu), whose current assembly contains 52,610 protein-coding genes approximately 92.3%...
Abstract Background Inflammation and maladaptive immune mechanisms have been substantiated as integral components in the critical pathological processes of injury cascade ischemic stroke (IS). This study aimed to explore associations between six systemic inflammatory indices IS a Chinese population. Methods was case-control based on retrospective review electronic medical records from two hospitals Shandong Province, China. Systemic indices, including inflammation response index (SIRI),...
Abstract Background Concurrent atherogenic dyslipidemia and elevated inflammation are commonly observed in overt hyperglycemia have long been proposed to contribute diabetogenesis. However, the temporal relationship between them effect of their cumulative co-exposure on future incident type 2 diabetes (T2D) remains unclear. Methods Longitudinal analysis data 52,224 participants from a real-world, prospective cohort study (Kailuan Study) was performed address high-sensitivity C-reactive...
Abstract Observational epidemiological studies have reported a relationship between remnant cholesterol and stroke. However, the results are inconclusive, causality remains unclear due to confounding or reverse causality. Our objective in this study was investigate causal relevance of risk stroke its subtypes using Mendelian randomization (MR) approach. Genome-wide association (GWASs) including 115,082 European individuals (UK Biobank) were used identify instruments for cholesterol,...
Recognising the early signs of ischemic stroke (IS) in emergency settings has been challenging. Machine learning (ML), a robust tool for predictive, preventive and personalised medicine (PPPM/3PM), presents possible solution this issue produces accurate predictions real-time data processing.This investigation evaluated 4999 IS patients among total 10,476 adults included initial dataset, 1076 subjects 3935 participants external validation dataset. Six ML-based models prediction were trained...
Salt stress has a detrimental impact on crop yield, quality, and profitability. The tau-like glutathione transferases (GSTs) represent significant group of enzymes that play crucial role in plant responses, including salt stress. In this study, we identified transferase family gene from soybean named GmGSTU23. Expression pattern analysis revealed GmGSTU23 was predominantly expressed the roots flowers exhibited concentration-time-specific response to Transgenic lines were generated subjected...
Both elevated inflammation and atherogenic dyslipidemia are prominent in young-onset diabetes increasingly identified as biologically intertwined processes that contribute to diabetogenesis. We aimed investigate the age-specific risks of type 2 (T2D) upon concomitant chronic dyslipidemia.Age-stratified Cox regression analysis risk incident co-exposure time-averaged cumulative high-sensitivity C-reactive protein (CumCRP) index plasma (CumAIP) among 42,925 nondiabetic participants from a...
Abstract Background The Mitogen-activated protein kinase 1 (MAPK1) has both independent functions of phosphorylating histones as a and directly binding the promoter regions genes to regulate gene expression transcription factor. Previous studies have identified elevated MAPK1 in human gastric cancer, which is associated with its role kinase, facilitating migration invasion cancer cells. However, how binds target factor whether it modulates related expressions remains unclear. Results Here,...
<i>Background:</i> Spontaneous intraventricular hemorrhage is an infrequent but severe complication of hemorrhagic stroke. The conventional treatment consists ventricular drainage or surgical evacuation, neither them encouraged. objective this article to compare different procedures in order evaluate a method minimally invasive for hemorrhage. <i>Methods:</i> Neuroendoscopy was applied treat 22 cases Twenty the same disease that were treated by external taken as...
Increased fasting plasma glucose (FPG) is an independent risk factor for type 2 diabetes mellitus (T2DM). The development of systems biology technologies integration multiomics data crucial predicting increased FPG levels. In this case–control study, immunoglobulin (Ig) G glycosylation profiling and genome-wide association analyses were performed on 511 participants, among them 76 had (aged 47.6 ± 6.14 years), 435 decreased or fluctuant 47.9 6.08 years). We identified nine single nucleotide...
Acute myeloid leukemia (AML) is a hematologic malignancy with increased lethality. We focused on elucidating the role of Neratinib, tyrosine kinase inhibitor, in progression AML and identify potential mechanisms. Upon treatment autophagy suppressor 3-methyladenine (3-MA) ferroptosis stimulator Erastin, viability proliferation HL-60 cells were evaluated by cell counting kit-8 5-Ethynyl-20-Deoxyuridine staining assays. A flow cytometer was to observe cycle apoptosis. Production reactive oxygen...
Metabolic syndrome (MetS) has been proposed as a clinically identifiable high-risk state for the prediction and prevention of cardiovascular diseases type 2 diabetes mellitus. As promising "omics" technology, metabolomics provides an innovative strategy to gain deeper understanding pathophysiology MetS. The study aimed systematically investigate metabolic alterations in MetS identify biomarker panels identification using machine learning methods.
Glioblastoma (GBM) is the most common intracranial malignancy, but current treatment options are limited. Super-enhancers (SEs) have been found to drive expression of key oncogenes in GBM. However, role SE-associated long non-coding RNAs (lncRNAs) GBM remains poorly understood. Here, we screened for an up-regulated lncRNA-SLCO4A1-AS1 expressed by analyzing data from GSE54791, GSE4536 and TCGA. We systematically analyzed its relationship with clinical characteristics, prognosis, epigenetics,...
Gastroesophageal reflux disease (GERD) is common worldwide. Although associations between sedentary behaviour (LSBs), physical activity (PAs), and GERD have been reported, their causal relationships remain unclear. This study uses Mendelian randomization (MR) to examine these with GERD. Genetic instruments from the UK Biobank other consortia were utilized assess relationship LSBs, PAs, Causal analyses employed inverse variance weighted (IVW), weighted-median (WM), MR-Egger regression....
Abstract Background Glioblastoma (GBM) represents a complex ecosystem characterized by numerous interactions between tumor cells and the surrounding microenvironment (TME). Here, we show that WNT10A, member of WNT family, plays an important role in GBM growth where its influence is mediated via both autocrine paracrine pathways thereby stimulating not only but also normal cell types within Methods In silico analysis was performed to identify high-expressing family members GBM. Knockdown...
SABATH gene family in plants participates metabolic processes such as methylation of various hormones and plays an essential role plant response to abiotic stress. In this study, we identified sequenced 28 genes soybean divided them into three groups. Genome mapping annotation suggested that tandem repeat was the cause amplification soybean. Phylogenetic homology analyses show groups may have originated from different ancestors. Transcriptome analysis performed six tissues using data public...
Rainfall and temperature are the primary limiting factors for optimum quality yield of cultivated jujube (Ziziphus jujuba Mill.). Adaptation to arid cool environments has been remains an important goal many improvement programs. This study summarized survey results 116 Chinese varieties grown at 33 sites in China. The objective was identify environmental that influence leaf morphology, implications breeding introduction new varieties. Jujube morphological traits were evaluated their...
Ziziphus Mill. (Rhamnaceae) is comprised of about 170 species that are mainly distributed in tropical to subtropical regions, with few the temperate zone. Several fruit tree important energy, nutrient, and medicinal resources for human populations, particularly those living rural regions. To date, limited genomic information available this genus. Here, we assembled complete chloroplast genomes four best known species, i.e., jujuba, acidojujuba, mauritiana, spina-christi, based on Illumina...
Type 2 diabetes mellitus (T2DM) is a common complex trait arising from interactions among multiple environmental, genomic, and postgenomic factors. We report here the first attempt to investigate association between immunoglobulin G (IgG) N-glycan patterns, T2DM, their clinical risk factors in an Australian population. N-glycosylation of proteins one most frequently observed co- post-translational modifications, reflecting, importantly, real-time status interplay genomic In community-based...
PurposeThis study aimed to evaluate the association between systemic inflammation markers and cognitive performance among older US adults.MethodsThis cross-sectional assessed 3,632 participants from 2011–2014 National Health Nutrition Examination Survey (NHANES). The main analysis included aged over 60 years. Systemic were quantified by calculating composite indicators blood routine count, was using Consortium Establish a Registry for Alzheimer’s Disease (CERAD) test, Animal Fluency test...