A5103071971- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Lipoproteins and Cardiovascular Health
- Kidney Stones and Urolithiasis Treatments
- Cancer, Hypoxia, and Metabolism
- Blood Pressure and Hypertension Studies
- Inflammatory Biomarkers in Disease Prognosis
- Methemoglobinemia and Tumor Lysis Syndrome
- Hematopoietic Stem Cell Transplantation
- Cardiac pacing and defibrillation studies
- Salivary Gland Tumors Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Thermoregulation and physiological responses
- Adrenal and Paraganglionic Tumors
- Burn Injury Management and Outcomes
- Lung Cancer Treatments and Mutations
- Academic integrity and plagiarism
- Cardiovascular Health and Risk Factors
- Genomic variations and chromosomal abnormalities
- Pituitary Gland Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- Congenital Heart Disease Studies
- Diabetes Treatment and Management
Second Affiliated Hospital of Shantou University Medical College
2021-2025
Shantou University
2021-2025
Shenzhen Institutes of Advanced Technology
2024
Chinese Academy of Sciences
2024
Xuzhou Medical College
2024
Second People’s Hospital of Huai’an
2024
Southwest General Health Center
2024
Southwest Hospital
2024
Army Medical University
2024
First Affiliated Hospital of Shantou University Medical College
2024
Abstract Background Concurrent atherogenic dyslipidemia and elevated inflammation are commonly observed in overt hyperglycemia have long been proposed to contribute diabetogenesis. However, the temporal relationship between them effect of their cumulative co-exposure on future incident type 2 diabetes (T2D) remains unclear. Methods Longitudinal analysis data 52,224 participants from a real-world, prospective cohort study (Kailuan Study) was performed address high-sensitivity C-reactive...
Abstract Background Previous studies using trajectory models focused on examining the longitudinal changes in triglyceride-glucose (TyG) levels and lifestyle scores separately, without exploring joint evolution of these two factors. This study aimed to identify multi-trajectories TyG assess their association with risk cardiovascular disease (CVD). Methods The enrolled 47,384 participants from three health surveys Kailuan Study. index was computed as Ln [fasting triglycerides (mg/dL) ×...
Both elevated inflammation and atherogenic dyslipidemia are prominent in young-onset diabetes increasingly identified as biologically intertwined processes that contribute to diabetogenesis. We aimed investigate the age-specific risks of type 2 (T2D) upon concomitant chronic dyslipidemia.Age-stratified Cox regression analysis risk incident co-exposure time-averaged cumulative high-sensitivity C-reactive protein (CumCRP) index plasma (CumAIP) among 42,925 nondiabetic participants from a...
Abstract Background The precise pathways connecting insulin resistance (IR) to atherosclerotic cardiovascular disease (ASCVD) remain undefined. present study aimed examine the mediating role of arterial stiffness in association between IR and ASCVD, providing epidemiology insights into potential mechanisms driving incident ASCVD. Methods A total 59,777 participants from Kailuan Study Arterial Stiffness Subcohort who were free ASCVD at baseline enrolled study. was assessed using baPWV by...
Abstract Background Concurrent insulin resistance and elevated blood pressure are commonly observed in cardiovascular disease (CVD) have long been proposed to contribute CVD. However, the temporal relationship between them effect of their cumulative co-exposure on future incident CVD remains unclear. Methods Longitudinal analysis data 57,192 participants from a real-world, prospective cohort study (Kailuan Study) was performed address Triglyceride-Glucose Index (TyG, calculated as ln [TG...
The Triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, has been implicated in the risk ischemic stroke. However, interplay between TyG levels, lifestyle factors, and their collective impact on stroke non-diabetic populations remains inadequately explored. This study aims to evaluate association with joint development index population.
Emerging evidence suggests a central role for inflammation in cardiac conduction disorder (CCD). It is unknown whether habitual physical activity could modulate the inflammation-associated risks of incident CCD general population.
Abstract Background Converging data have suggested that monocytic inflammation and C-reactive protein (CRP) are biologically intertwined processes involved in diabetogenesis. This study aimed to investigate the association between systemic assessed by joint cumulative high-sensitivity (CumCRP) monocyte high-density lipoprotein ratio (CumMHR) incident type 2 diabetes (T2D) their predictive value for T2D a general population. Methods A total of 40,813 nondiabetic participants from prospective...
// Weiyan Xie 1,2,* , Chunhui Liu 2,* Dan Wu 3 Zhenye Li 2 Chuzhong 1,2 and Yazhuo Zhang 1 Beijing Neurosurgical Institute, Capital Medical University, Beijing, China Tiantan Hospital, Neurological Department, Renhe * These authors have contributed equally to this work Correspondence to: Zhang, email: Keywords : CDK5; KDR; phosphorylation; prolactinomas; invasiveness; Pathology Section Received November 06, 2015 Accepted June 29, 2016 Published July 12, Abstract Pituitary adenomas constitute...
Abstract Background Recent studies have established that monocyte-derived inflammation plays a central role in the pathogenesis of type 2 diabetes mellitus (T2DM). It is unclear whether chronic metabolic inflammation, reflected by cumulative monocyte to high-density lipoprotein ratio (CumMHR), predisposes general population T2DM. Methods This study included 40,813 participants without from real-life, community-based cohort (the Kailuan Study) attending 2-year cycle health survey since 2006....
The purpose of this study was to identify potential molecular markers lung squamous cell carcinoma (LUSC). Three datasets containing LUSC mRNA sequencing data were downloaded from the Gene Expression Omnibus, Cancer Genome Atlas and Profiling Interactive Analysis databases. These used significantly differentially expressed genes (DEGs) in LUSC. A protein‑protein interaction network DEGs constructed followed by Ontology, Kyoto Encyclopedia Genes Genomes overall survival analyses DEGs. total...
Abstract Background Adiposity and elevated inflammation are two hallmarks of hyperglycemia. However, it is unknown whether clustering adiposity interact act on diabetogenesis lead to a greater risk for incident type 2 diabetes (T2D). Methods was indicated by body mass index, waist circumference ultrasonography-measured fatty liver degrees. Elevated as high-sensitivity C-reactive protein levels ≥ mg/L. Time-to-event survival analyses were conducted investigate the joint effect T2D both...
Extracranial arteriosclerosis usually indicates a high risk of ischemic stroke. In the past, clinical decision following diagnosis was dependent on percentage vessel stenosis determined by an invasive technique. We aimed to develop quantitative magnetic resonance (QMR) technique evaluate artery structure and cerebral hemodynamics noninvasively. QMR digital subtraction angiography (DSA) were performed in 67 patients with suspected vascular disease at our hospital. Accuracy, sensitivity,...
Severe burn injury causes a hypermetabolic response, resulting in muscle protein catabolism and multiple organ damage syndrome. However, this response has not yet been continuously characterized by metabolomics patients. This study aims to quantify temporal changes the metabolic processes of patients with severe burns. We employed 1H-nuclear magnetic resonance (NMR) spectroscopy scrutinize alterations during initial 35 days following cohort 17 adult burns, 10 healthy individuals included as...
Abstract Background Intestinal stem cells (ISCs) play a pivotal role in maintaining intestinal homeostasis and facilitating the restoration of mucosal barrier integrity. Glutamine (Gln) is crucial energy substrate intestine, promoting proliferation ISCs mitigating damage to after burn injury. However, underlying mechanism has not yet been fully elucidated. The objective this study was explore by which Gln facilitates ISCs. Methods A mouse model established investigate impact on function....
Objectives To examine the association between age at onset of diabetes and risk all-cause mortality in a population individuals diagnosed with type 2 mellitus (T2DM) to identify factors associated young-onset T2DM (YOD) patients China. Methods This study utilized cohort 9759 who were registered enrolled National Basic Public Health Service Management Program Qinghe District (now Qingjiangpu District) Huai’an District, City, Jiangsu Province, The observed from November 2013 July 2014, data...
Abstract: Staghorn renal calculi are large, branched stones in the kidney that partially or completely fill pelvis and calyces. Percutaneous nephrolithotomy (PCNL) is gold standard treatment for staghorn calculi. However, we report a retrograde intrarenal surgery (RIRS) performed to treat calculus patient with solitary deformed urinary tract. The 37-year-old male presented right-sided lumbar pain. computed tomography (CT) scan found on right side an opaque 4.5 cm × 2.4 stone grade I...
Deletion in the Xp22.31 region is increasingly suggested to be involved etiology of epilepsy. Little known regarding genomic and clinical delineations X-linked epilepsy Chinese population or sex-stratified difference characteristics associated with deletions region. In this study, we reported two siblings a 1.69 Mb maternally inherited microdeletion at involving genes VCX3A, HDHD1, STS, VCX, VCX2, PNPLA4 presenting easily controlled focal language delay mild ichthyosis family traceable...
This study aimed to examine the clinical usefulness of chromosome microarray (CMA) for selective implementation in patients with unexplained moderate or severe developmental delay/intellectual disability (DD/ID) and/or combined different dysphonic features Han Chinese population.We retrospectively analyzed data on 122 pediatric isolated moderate/severe DD/ID without autism spectrum disorders, epilepsy, dystonia, and congenital abnormalities from a single-center neurorehabilitation clinic...