Abstract Background It has been suggested that the baseline triglyceride-glucose (TyG) index, a simple surrogate measure for insulin resistance, is significantly associated with occurrence of stroke. Nevertheless, impact longitudinal patterns TyG on stroke risk in hypertensive patients still unknown. Hence, this study aimed to investigate association between index trajectory and among patients. Methods This prospective included 19,924 from Kailuan Study who underwent three waves survey were...

Background: Studies have demonstrated that remnant cholesterol is correlated with the risk of ischemic stroke. However, it unknown whether visit-to-visit variability in concentration affects We sought to examine role subsequent development stroke general population. Methods: performed a post hoc analysis including eligible participants from Kailuan Study cohort who underwent 3 health examinations and were free atrial fibrillation, myocardial infarction, stroke, cancer, or known...

Abstract Background A single measurement of the triglyceride-glucose (TyG) index, a simple and reliable surrogate marker insulin resistance, is associated with ischemic stroke. However, evidence for an effect long-term elevation in TyG index on stroke limited. Therefore, we evaluated relationship between cumulative exposure risk Methods total 54,098 participants Kailuan study who had not experienced underwent three measurements fasting blood glucose triglycerides during 2006–2007, 2008–2009,...

Abstract Background High triglyceride-glucose index (TyG) is a major risk factor for heart failure, but the long-term effect of high TyG on developing failure remains unclear. Therefore, we aimed to determine relationship between cumulative exposure and failure. Methods A total 56,149 participants from Kailuan Study, who participated in three consecutive health examinations 2006, 2008, 2010 had no history or cancer were recruited this study. The was calculated as weighted sum (value × time)...

Abstract Background Atherogenic index of plasma (AIP) has been demonstrated as a surrogate marker for ischemic stroke, but there is limited evidence the effect long-term elevation AIP on stroke. Therefore, we aimed to characterize relationship between cumulative exposure and risk Methods A total 54,123 participants in Kailuan Study who attended consecutive health examinations 2006, 2008, 2010 had no history stroke or cancer were included. The time-weighted (cumAIP) was calculated weighted...

Abstract Background The relationship of cumulative remnant-cholesterol (Cum-RC) concentration with the risk cardiovascular disease (CVD) in patients hypertension remains unclear. Methods We studied data for 28,698 individuals whom three consecutive total cholesterol, high-density lipoprotein-cholesterol (HDL-C), and triglyceride concentrations were available, who did not have CVD (14,349 14,349 without), that was collected between 2006 2010. Participants placed into four groups based on...

A higher ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) is considered as the independent risk index cardiovascular (CV) events. However, cohort studies regarding this correlation are rarely reported, especially in Chinese population. The aim present study was explore relationship TG/HDL-C with CV risks among adults during 10-year follow-up period.

The aim of this study was to examine the association between age at onset overweight and incident hypertension.We analysed 4742 participants with new-onset from Kailuan 2006 2015 age-matched sex-matched controls selected randomly same cohort but normal weight. Participants were compared respect subsequent risk hypertension, sub-HR calculated Fine Gray model, according overweight.Over a mean follow-up period 5.17 years, 1642 (34.6%) 1293 normal-weight (27.3%) subsequently diagnosed...

The atherogenic index of plasma (AIP) has been shown to be positively correlated with cardiovascular events. However, it remains unclear whether hypertensive patients long-term high AIP levels are at greater risk developing heart failure (HF). Therefore, the aim this study was investigate association between trajectory and incidence HF in patients. This prospective included 22,201 from Kailuan Study who underwent three waves surveys 2006 2010. Participants were free or cancer before during...

Abstract On the basis of 45,092 participants (mean age 54.04 ± 13.09 years) from Kailuan study, this study was performed to explore relationships among total cholesterol (TC), brachial-ankle pulse wave velocity (BaPWV), and systolic blood pressure (SBP) quantify their separate effects. The correlations TC, SBP, BaPWV were analyzed using multivariate linear regression models. Mediation analysis determine whether effect TC on SBP can be explained by arterial stiffness. Multivariate showed that...

Background Metabolic syndrome (MetS) is associated with an increased risk of incident cardiovascular diseases (CVD), but the association between new-onset MetS at different ages and CVD remain unclear. Methods This was a prospective study comprising total 72,986 participants without who participated in Kailuan baseline survey (July 2006 to October 2007). All received biennial follow-up visit until December 31, 2019. In addition, 26,411 patients were identified from follow-up, one control...

Abstract Background Concurrent insulin resistance and elevated blood pressure are commonly observed in cardiovascular disease (CVD) have long been proposed to contribute CVD. However, the temporal relationship between them effect of their cumulative co-exposure on future incident CVD remains unclear. Methods Longitudinal analysis data 57,192 participants from a real-world, prospective cohort study (Kailuan Study) was performed address Triglyceride-Glucose Index (TyG, calculated as ln [TG...

<title>Abstract</title> Objective Liver cancer is a significant contributor to the global disease burden. we first provide estimates of worldwide burden liver from 2000 2021 in middle-aged and elderly people with decomposition, cross-country inequality frontier analysis. Methods The age-standardized rate (ASR) estimated annual percentage change (EAPC) were utilized for measuring prevalence, incidence, deaths disability-adjusted life years (DALYs) trends. Decomposition, cross country...

The association between changes in cardiovascular health score (CHS) over time and myocardial infarction (MI) risk hypertensive patients remains unclear.This was a prospective study comprising 17 374 from the Kailuan cohort who underwent 3 surveys were identified to be free of MI, stroke, or cancer 2006 2010. CHS consisted 7 metrics (plasma glucose, total cholesterol, blood pressure, smoking, body mass index, physical activity, salt intake), ranging 0 (worst) 13 (best) study. trajectories...

Hyperlipidemia is associated with arterial stiffness. Herein, We examined the effect of prolonged exposure to hyperlipidemia on risk stiffness in young adults.A study cohort (35-55 years old) that received health check-ups Kailuan (2014-2016) were assessed. was defined as a low-density lipoprotein cholesterol ≥160 mg/dL according Chinese Guidelines for Management Dyslipidemia Adults. Subjects divided into three groups based number hyperlipidemia: normal (0 years), low (1-5 and high (5-10...

Abstract Understanding how plasmonic nanostructures generate heat upon exposure to light, and thus increase the local temperature of surrounding medium is important for many applications. Reliable manipulation requires analyzing distribution as a function laser density. In this work, an optical heating system containing silver nano-islands (Ag NIs) designed enable generation at micro/nanometer scale can reach 1458 K. The by Ag NIs exposed near-IR distribution, are detected in situ via...

Instruction/Aims It is unknown whether variability in the triglyceride-glucose index (TyG-index) associated with risk of diabetes. Here, we sought to characterize relationship between TyG-index and incident Methods We performed a prospective study 48,013 participants Kailuan Study who did not have The was calculated as ln [triglyceride (TG, mg/dL) concentration × fasting blood glucose (FBG, mg/dL)/2]. assessed using standard deviation (SD) three values that were during 2006/07, 2008/09,...

Background The relationship of cumulative non high-density lipoprotein-cholesterol (Cum-non-HDL-C) concentration with the risk cardiovascular disease (CVD) in individuals hypertension remains unclear.

Abstract Aims/Introduction The correlation between triglyceride to high‐density lipoprotein cholesterol (TG/HDL‐C) ratio variability and incident diabetes has not been fully elucidated. We aimed characterize the relationship TG/HDL‐C new‐onset in Chinese adults. Materials Methods A total of 45,911 patients with three TG HDL measurements 2006 2011 were enrolled. Average real (ARV) used evaluate variability, participants grouped according tertiles TG/HDL‐ARV. Results There 3,724 cases mellitus...

We sought to examine the relationship between visit-to-visit variability of SBP and incident atrial fibrillation in middle-aged older population.This prospective cohort study included 26 999 participants aged 50 years or at entry. Visit-to-visit was defined as average real (ARV) three values from examinations 2006, 2008, 2010. categorized into four groups according quartiles ARV. Incident cases were identified via ECG during biennial resurveys, reviewing medical insurance record discharge...

Background Body fat percentage were positively correlated with arterial stiffness, but the acute change in stiffness after aerobic exercise individuals different body percentages remains unclear. This study was aimed to determine effect of on percentages. Methods Individuals who both participated seventh survey Kailuan and fifth iteration National Physical Fitness Monitoring enrolled our study. All participants underwent measurement brachial–ankle pulse wave velocity, blood pressure, heart...

The relationship between long-term body mass index (BMI) variability, weight change slope, and risk of cardiovascular outcomes in Chinese hypertensive patients has not been fully elucidated.A total 20,737 with hypertension three BMI measurements 2006 2011 were included. Average real variability (ARV) was used to evaluate the subjects divided into groups: tertile 1 BMI_ARV ≤0.86; 2 0.86 < ≤ 1.60; 3 >1.60. Cox proportional-hazards models analyze cerebrovascular diseases (CVD) each group.There...

Abstract This study aimed to investigate the immediate effects of acute bout aerobic exercise on arterial stiffness in individuals with different smoking statuses. A total 940 male (mean age 36.82±7.76 years) Kailuan cohort were selected participate fifth National Physical Fitness Monitoring. All participants completed measurements brachial – ankle pulse wave velocity (baPWV) before and after twice-quantitative cycle ergometer exercise. Four groups defined: (1) non-smokers (n=231), (2)...

Over the past decades, China has seen a dramatic epidemic of overweight and obesity. However, optimal period for interventions to prevent overweight/obesity in adulthood remains unclear, little is known regarding joint effect sociodemographic factors on weight gain. We aimed investigate associations gain with factors, including age, sex, educational level, income.This was longitudinal cohort study.This study included 121,865 participants aged 18-74 years from Kailuan who attended health...

Objective We aimed to characterize the relationship of a combination circulating non-high-density lipoprotein-cholesterol (non-HDL-C) concentration and brachial-ankle pulse wave velocity (baPWV) with cardiovascular disease (CVD). Methods performed prospective cohort study residents Kailuan community, data from total 45,051 participants being included in final analysis. The were allocated four groups according their non-HDL-C baPWV status, each which was categorized as high or normal. Cox...